Open Access
ARTICLE
Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo
Qian Li, Jing Jin, Jianghui Liu, Liqun Wang, Yutong He
Cancer Institute, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
Oncology Research 2016, 24(3), 205-214. https://doi.org/10.3727/096504016X14648701447896
Abstract
We recently found that SLC39A5 (ZIP5), a zinc transporter, is overexpressed in esophageal cancer. Downregulation of ZIP5 inhibited the proliferation, migration, and invasion of the esophageal cancer cell line
KYSE170 in vitro. In this study, we found that downregulation of SLC39A5 (ZIP5) by interference resulted
in a significant reduction in esophageal cancer tumor volume and weight in vivo. COX2 (cyclooxygenase 2)
expression was decreased and E-cadherin expression was increased in the KYSE170K xenografts, which was
caused by the downregulation of ZIP5. However, we did not find that the downregulation of ZIP5 caused a
change in the relative expressions of cyclin D1, VEGF (vascular endothelial growth factor), MMP9 (matrix
metalloprotein 9), and Bcl-2 (B-cell lymphoma/leukmia-2) mRNA or an alteration in the average level of
zinc in the peripheral blood and xenografts in vivo. Collectively, these findings indicate that knocking down
ZIP5 by small interfering RNA (siRNA) might be a novel treatment strategy for esophageal cancer with
ZIP5 overexpression.
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Cite This Article
APA Style
Li, Q., Jin, J., Liu, J., Wang, L., He, Y. (2016). Knockdown of zinc transporter ZIP5 by RNA interference inhibits esophageal cancer growth in vivo. Oncology Research, 24(3), 205-214. https://doi.org/10.3727/096504016X14648701447896
Vancouver Style
Li Q, Jin J, Liu J, Wang L, He Y. Knockdown of zinc transporter ZIP5 by RNA interference inhibits esophageal cancer growth in vivo. Oncol Res. 2016;24(3):205-214 https://doi.org/10.3727/096504016X14648701447896
IEEE Style
Q. Li, J. Jin, J. Liu, L. Wang, and Y. He "Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo," Oncol. Res., vol. 24, no. 3, pp. 205-214. 2016. https://doi.org/10.3727/096504016X14648701447896