Table of Content

Open Access iconOpen Access

ARTICLE

Knockdown of Long Noncoding RNA ENST457720 Inhibits Proliferation of Non-Small Cell Lung Cancer Cells In Vitro and In Vivo

Jia Yu, Qiyu Fang, Shuyan Meng

Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, P.R. China

Oncology Research 2019, 27(1), 47-53. https://doi.org/10.3727/096504018X15193843443255

Abstract

Non-small cell lung cancer (NSCLC) represents the leading cause of cancer-related mortality worldwide. More and more reports have identified important roles for long noncoding RNAs (lncRNAs) in cancer development. ENST457720 expression was upregulated in lung adenocarcinoma in a microarray-based lncRNA screen. We determined the expression levels of ENST457720 in NSCLC tissues with quantitative real-time PCR and then studied their clinical significance. We explored the biological significance of ENST457720 with gain- and lossof-function analyses in vitro and in vivo. In this study, ENST457720 was expressed at higher levels in NSCLC tissues than in paired normal tissues. Higher ENST457720 expression was associated with larger tumor sizes, lymph node metastasis, and advanced TNM stage. ENST457720 silencing suppressed NSCLC cell proliferation in vitro and in vivo. Moreover, ENST457720 knockdown inhibited NSCLC invasion and reversed the epithelial-to-mesenchymal transition. ENST457720 promoted NSCLC proliferation and invasion, which may be a novel potential therapeutic target for NSCLC.

Keywords


Cite This Article

APA Style
Yu, J., Fang, Q., Meng, S. (2019). Knockdown of long noncoding RNA ENST457720 inhibits proliferation of non-small cell lung cancer cells in vitro and in vivo. Oncology Research, 27(1), 47-53. https://doi.org/10.3727/096504018X15193843443255
Vancouver Style
Yu J, Fang Q, Meng S. Knockdown of long noncoding RNA ENST457720 inhibits proliferation of non-small cell lung cancer cells in vitro and in vivo. Oncol Res. 2019;27(1):47-53 https://doi.org/10.3727/096504018X15193843443255
IEEE Style
J. Yu, Q. Fang, and S. Meng "Knockdown of Long Noncoding RNA ENST457720 Inhibits Proliferation of Non-Small Cell Lung Cancer Cells In Vitro and In Vivo," Oncol. Res., vol. 27, no. 1, pp. 47-53. 2019. https://doi.org/10.3727/096504018X15193843443255



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 674

    View

  • 403

    Download

  • 0

    Like

Share Link