Open Access
ARTICLE
Different Types of ROS1 Fusion Partners Yield Comparable Efficacy to Crizotinib
Yueming He*1,
Wang Sheng†1,
Weiguo Hu‡1,
Jing Lin§, Junjun Liu§, Bing Yu§,
Xinru Mao§, Lu Zhang§, Jin Huang¶, Guangsuo Wang#
* Department of Respiration, Quanzhou First Hospital, Fujian Medical University, Quanzhou, P.R. China
† Department of Medical Oncology, Cancer Hospital, The First Affiliated Hospital of Xiamen University,
Teaching Hospital of Fujian Medical University, Xiamen, P.R. China
‡ Center of Oncology, Renmin Hospital of Wuhan University, Wuhan, P.R. China
§ Burning Rock Biotech, Guangzhou, P.R. China
¶ Department of Oncology, Xiangya Hospital, Central South University, Changsha, P.R. China
# Department of Thoracic Surgery, Shenzhen People’s Hospital, Second Affiliated Hospital,
Medical College of Ji’nan University, Shenzhen, P.R. China
Oncology Research 2019, 27(8), 901-910. https://doi.org/10.3727/096504019X15509372008132
Abstract
ROS1 rearrangements define a distinct molecular subset of non-small-cell lung cancer (NSCLC), which can be
treated effectively with crizotinib, a tyrosine kinase inhibitor (TKI) targeting
ROS1/MET/ALK rearrangements.
Diverse efficacy was observed in
ROS1-rearranged NSCLC patients. Because of its rareness, very limited
studies have investigated the correlation between different fusion partners and response to crizotinib. In this
study, we retrospectively screened 6,235 advanced NSCLC patients (stage IIIB to IV) from five hospitals and
identified 106 patients with
ROS1 rearrangements based on either plasma or tumor tissue testing using capturebased targeted sequencing. The most frequently occurring fusion partners included cluster of differentiation 74
(CD74), ezrin (EZR), syndecan 4 (SDC4), and tropomyosin 3 (TPM3), occurring in 49.1%, 17%, 14.2%, and
4.7% of patients, respectively. Among them, 38 patients were treated with crizotinib. Seventeen patients were
treatment naive, and the remaining were previously treated with pemetrexed-based chemotherapy. Collectively,
there was no significant difference among patients with various types of
ROS1 fusion partners in overall survival (OS) and progression-free survival (PFS). Patients who were treated with crizotinib as first-line therapy
showed comparable PFS (p=0.26) to patients who were previously treated with pemetrexed-based chemotherapy. For treatment-naive patients, patients with low baseline
ROS1 allelic fraction (AF) had a statistically
significant longer OS than those with high
ROS1 AF (184 vs. 110 days,
p=0.048). Collectively, our study
demonstrates that
ROS1+
patients with various fusion partners show comparable efficacy to crizotinib.
Keywords
Cite This Article
He, Y., Sheng,
. W., Hu,
. W., Lin,
. J., Liu, J. et al. (2019). Different Types of
ROS1 Fusion Partners Yield Comparable Efficacy to Crizotinib.
Oncology Research, 27(8), 901–910. https://doi.org/10.3727/096504019X15509372008132