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Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN
Jianjun Shen*1, Weina Niu†1, Hongbo Zhang*, Ma Jun*, Hongyan Zhang*
* Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, Anhui, P.R. China
† Department of Oncology, Anhui Cancer Hospital, Hefei, Anhui, P.R. China
Oncology Research 2020, 28(9), 961-963. https://doi.org/10.3727/096504022X16414984936746
Abstract
Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths
worldwide. This study aimed to investigate the expression patterns, biological roles, and underlying mechanisms of microRNA-147 (miR-147) in gastric cancer. The present study demonstrated that miR-147 was
significantly upregulated in gastric cancer tissues and cell lines. Downregulation of miR-147 decreased cell
proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-fluorouracil (5-FU) through the
cell apoptosis pathway. In addition, phosphatase and tensin homolog (PTEN) was mechanically identified as
the direct target of miR-147 in gastric cancer. PTEN knockdown reversed the effects of miR-147 downregulation on the proliferation, chemosensitivity, and 5-FU-induced apoptosis of gastric cancer cells. Moreover,
miR-147 regulated the PI3K/AKT signaling pathway in gastric cancer by targeting PTEN. In conclusion,
miR-147 suppressed the proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-FU by
promoting cell apoptosis through directly targeting PTEN and regulating the PI3K/AKT signaling pathway.
This study provides important insight into the molecular mechanism that underlies the chemoresistance of
gastric cancer cells. The results of this study could aid the development of a novel therapeutic strategy for
gastric cancer.
Keywords
Cite This Article
Shen, J., Niu, W., Zhang, H., Jun, M., Zhang, H. (2020). Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN.
Oncology Research, 28(9), 961–963.