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Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN

Jianjun Shen*1, Weina Niu†1, Hongbo Zhang*, Ma Jun*, Hongyan Zhang*

* Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, Anhui, P.R. China
† Department of Oncology, Anhui Cancer Hospital, Hefei, Anhui, P.R. China

Oncology Research 2020, 28(9), 961-963. https://doi.org/10.3727/096504022X16414984936746

Abstract

Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths worldwide. This study aimed to investigate the expression patterns, biological roles, and underlying mechanisms of microRNA-147 (miR-147) in gastric cancer. The present study demonstrated that miR-147 was significantly upregulated in gastric cancer tissues and cell lines. Downregulation of miR-147 decreased cell proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-fluorouracil (5-FU) through the cell apoptosis pathway. In addition, phosphatase and tensin homolog (PTEN) was mechanically identified as the direct target of miR-147 in gastric cancer. PTEN knockdown reversed the effects of miR-147 downregulation on the proliferation, chemosensitivity, and 5-FU-induced apoptosis of gastric cancer cells. Moreover, miR-147 regulated the PI3K/AKT signaling pathway in gastric cancer by targeting PTEN. In conclusion, miR-147 suppressed the proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-FU by promoting cell apoptosis through directly targeting PTEN and regulating the PI3K/AKT signaling pathway. This study provides important insight into the molecular mechanism that underlies the chemoresistance of gastric cancer cells. The results of this study could aid the development of a novel therapeutic strategy for gastric cancer.

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APA Style
Shen, J., Niu, W., Zhang, H., Jun, M., Zhang, H. (2020). Downregulation of microrna-147 inhibits cell proliferation and increases the chemosensitivity of gastric cancer cells to 5-fluorouracil by directly targeting PTEN. Oncology Research, 28(9), 961-963. https://doi.org/10.3727/096504022X16414984936746
Vancouver Style
Shen J, Niu W, Zhang H, Jun M, Zhang H. Downregulation of microrna-147 inhibits cell proliferation and increases the chemosensitivity of gastric cancer cells to 5-fluorouracil by directly targeting PTEN. Oncol Res. 2020;28(9):961-963 https://doi.org/10.3727/096504022X16414984936746
IEEE Style
J. Shen, W. Niu, H. Zhang, M. Jun, and H. Zhang "Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN," Oncol. Res., vol. 28, no. 9, pp. 961-963. 2020. https://doi.org/10.3727/096504022X16414984936746



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