Open Access

REVIEW

Advances in Expression Regulation, Molecular Targeting Mechanisms, and Therapeutic Applications of the Let-7 MicroRNA Family in Gastric Cancer

Xinke Chai, Shifeng Wu, Qian Shen, Qiulin Huang^*

The First Affiliated Hospital, Department of Gastrointestinal Surgery, Hengyang Medical School, University of South China, Hengyang, 421001, China

* Corresponding Author: Qiulin Huang. Email:

(This article belongs to the Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)

Oncology Research 2025, 33(12), 3731-3752. https://doi.org/10.32604/or.2025.067546

Received 06 May 2025; Accepted 21 July 2025; Issue published 27 November 2025

Abstract

Gastric cancer (GC) is a prevalent malignant tumor globally, with high incidence and mortality rates. Advances in understanding molecular mechanisms underlying GC have highlighted the role of microRNAs (miRNAs) in its initiation, progression, and treatment. The Let-7 family, an important class of miRNAs, is closely associated with the biological behaviors of GC. Aberrant expression of various Let-7 family members in GC patients contributes to disease progression, as they target multiple molecular pathways and participate in diverse regulatory mechanisms throughout GC pathogenesis. This article systematically summarizes the expression patterns of Let-7 family members in GC, explores their influence on GC cell behaviors such as proliferation, invasion, and metastasis through key target gene regulation, and reviews current advances in Let-7-based interventions for GC treatment. It aims to provide foundational insights for a deeper understanding of Let-7-related mechanisms in GC and optimize therapeutic strategies.

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Keywords

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