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One Novel Nortriterpenoid from the Mastic (Pistacia lentiscus) and Its Anti-Inflammatory Activity

by Yan Wu1, Xuerui An1, Haofan Lv1, Zhiqiang Zhao1, Wei Liu1,2,*, Chunpeng Wan1,3,*

1 Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Yining, 835000, China
2 Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources, School of Chemistry and Chemical Engineering, Yili Normal University, Yining, 835000, China
3 Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits and Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, China

* Corresponding Authors: Wei Liu. Email: email; Chunpeng Wan. Email: email

Phyton-International Journal of Experimental Botany 2025, 94(1), 199-207. https://doi.org/10.32604/phyton.2025.059581

Abstract

A novel pair of oleanane nor-triterpenes, with compound 1 featuring a unique 18α-H structure, was isolated from mastic, and this compound represents a noteworthy new entity not previously reported in the literature. The absolute configurations of their structures were further determined using a combination of different analytical methods such as NMR, high-resolution mass spectrometry (HR-MS), ultraviolet (UV), infrared (IR) and single-crystal X-ray diffraction (SXRD). The compound actively mitigated inflammations by efficiently quenching nitric oxide (NO) synthesis within an ex vivo system using lipopolysaccharide activated murine macrophage RAW264.7 cells. Moreover, compound 1 exhibit a better IC50 concentration of 11.69 ± 1.39 µM, surpassing the efficacy of the positive control dexamethasone, which exhibited an IC50 of 23.21 ± 1.17 μM. While compound 2 also demonstrated inhibitory activity, its potency was comparatively weaker, with an IC50 of 26.18 ± 2.66 μM.

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APA Style
Wu, Y., An, X., Lv, H., Zhao, Z., Liu, W. et al. (2025). One novel nortriterpenoid from the mastic (pistacia lentiscus) and its anti-inflammatory activity. Phyton-International Journal of Experimental Botany, 94(1), 199–207. https://doi.org/10.32604/phyton.2025.059581
Vancouver Style
Wu Y, An X, Lv H, Zhao Z, Liu W, Wan C. One novel nortriterpenoid from the mastic (pistacia lentiscus) and its anti-inflammatory activity. Phyton-Int J Exp Bot. 2025;94(1):199–207. https://doi.org/10.32604/phyton.2025.059581
IEEE Style
Y. Wu, X. An, H. Lv, Z. Zhao, W. Liu, and C. Wan, “One Novel Nortriterpenoid from the Mastic (Pistacia lentiscus) and Its Anti-Inflammatory Activity,” Phyton-Int. J. Exp. Bot., vol. 94, no. 1, pp. 199–207, 2025. https://doi.org/10.32604/phyton.2025.059581



cc Copyright © 2025 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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