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One Novel Nortriterpenoid from the Mastic (Pistacia lentiscus) and Its Anti-Inflammatory Activity
1 Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Yining, 835000, China
2 Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources, School of Chemistry and Chemical Engineering, Yili Normal University, Yining, 835000, China
3 Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits and Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, China
* Corresponding Authors: Wei Liu. Email: ; Chunpeng Wan. Email:
Phyton-International Journal of Experimental Botany 2025, 94(1), 199-207. https://doi.org/10.32604/phyton.2025.059581
Received 11 October 2024; Accepted 16 December 2024; Issue published 24 January 2025
Abstract
A novel pair of oleanane nor-triterpenes, with compound 1 featuring a unique 18α-H structure, was isolated from mastic, and this compound represents a noteworthy new entity not previously reported in the literature. The absolute configurations of their structures were further determined using a combination of different analytical methods such as NMR, high-resolution mass spectrometry (HR-MS), ultraviolet (UV), infrared (IR) and single-crystal X-ray diffraction (SXRD). The compound actively mitigated inflammations by efficiently quenching nitric oxide (NO) synthesis within an ex vivo system using lipopolysaccharide activated murine macrophage RAW264.7 cells. Moreover, compound 1 exhibit a better IC50 concentration of 11.69 ± 1.39 µM, surpassing the efficacy of the positive control dexamethasone, which exhibited an IC50 of 23.21 ± 1.17 μM. While compound 2 also demonstrated inhibitory activity, its potency was comparatively weaker, with an IC50 of 26.18 ± 2.66 μM.Keywords
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