Mario D’Ambrosio¹, Elisabetta Bigagli^1,*, Lorenzo Cinci¹, Cecilia Brunetti^2,*, Edgardo Giordani³, Francesco Ferrini³, Cristina Luceri¹

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.073250 - 30 January 2026

Abstract Moringa oleifera (MO) is traditionally used to mitigate inflammatory-mediated disorders; however, the influence of ecotypic variation on its anti-inflammatory activity remains poorly understood. In this study, we compared the phytochemical composition and anti-inflammatory activity of ethanolic extracts obtained from fresh and dried leaves of four MO ecotypes (India, Paraguay, Mozambique, and Pakistan), all grown under the same outdoor conditions, as well as two commercial powders (Just Moringa and WISSA), using LPS-stimulated RAW 264.7 macrophages. Extracts from fresh leaves were 19–43% more cytotoxic than those from dried leaves, depending on the ecotype, likely due to higher cyanogenic… More >

Rebecca H. Maggs^*, Marcus J. Brookes, Kenneth S. Rankin

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069781 - 19 January 2026

Abstract Background: Photodynamic therapy (PDT) may eradicate residual malignant cells following sarcoma resection, through reactive oxygen species (ROS) mediated cytotoxicity, thus improve clinical outcomes. This study aims to assess the efficacy of 5-aminolevulinic acid (5-ALA) as a photosensitizer in combination with red light (RL) for PDT of bone sarcoma cells in vitro. Methods: Three bone sarcoma cell lines underwent treatment with 5-ALA and RL or sham-RL (SL). 5-ALA uptake was assessed using flow cytometry. Production of ROS was measured using CellROX Green staining and fluorescence microscopy. Cell viability was assessed using Cell Counting Kit-8 assays. Results: All cell… More >

Yuri A. Piven¹, Danila V. Sorokin², Nastassia A. Varabyeva¹, Alexandra L. Mikhaylova², Fedor B. Bogdanov², Elena V. Shafranovskaya¹, Raman M. Puzanau³, Fedor A. Lakhvich¹, Alexander M. Scherbakov^2,4,*

Oncology Research, Vol.33, No.12, pp. 4049-4072, 2025, DOI:10.32604/or.2025.067832 - 27 November 2025

Abstract Background: The most aggressive forms of breast cancer are characterized by independence from steroid hormones but a strong dependence on growth factors. In such cancer cells, oncogenic receptors, including human epidermal growth factor receptor 2 (HER2), are activated, and their targeted inhibition represents an attractive therapeutic strategy. The study aimed to develop small-molecule potential dual heat shock protein 90 (HSP90)-HER2 inhibitors and evaluate them as anticancer agents in HER2-positive cells. Methods: The research project involved obtaining a series of compounds with potential dual inhibitory activity against HSP90 and HER2 by targeted organic synthesis, which was… More > Graphic Abstract

Lucila M. Curi^*, Maria C. Area, Maria E. Vallejos

Journal of Renewable Materials, Vol.13, No.11, pp. 2109-2137, 2025, DOI:10.32604/jrm.2025.02025-0069 - 24 November 2025

Abstract The global demand for renewable and sustainable non-petroleum-based resources is rapidly increasing. Lignocellulosic biomass is a valuable resource with broad potential for nanocellulose (NC) production. However, limited studies are available regarding the potential toxicological impact of NC. We provide an overview of the nanosafety implications associated mainly with nanofibrillated cellulose (CNF) and identify knowledge gaps. For this purpose, we present an analysis of the studies published from 2014 to 2025 in which the authors mention aspects related to toxicity in the context of packaging. We also analyze the main methods used for toxicity evaluations and… More > Graphic Abstract

Hay Mon Aung¹, Aung Htay Naing^2,*, Chang Kil Kim², Kyeung II Park^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2719-2727, 2025, DOI:10.32604/phyton.2025.068713 - 30 September 2025

Abstract Phalaenopsis orchids are economically important ornamental crops; however, their commercial micropropagation is often limited by poor rooting efficiency and inconsistent growth. In this study, we investigated the effects of silver nanoparticles (Ag-NPs) on the in vitro regeneration and growth of Phalaenopsis cultivar 611B to determine the optimal concentration of Ag-NPs for improved micropropagation outcomes. Shoot tip explants (2–3 mm)—derived from protocorm-like bodies were cultured on a regeneration medium containing Hyponex (20:20:20 and 6.5:6.5:19), 18 g/L sugar, 2 g/L peptone, 0.8 g/L activated charcoal, 12.5 g/L potato extract, 50 mL/L apple juice, and 10 mg/L 6-benzylaminopurine (6-BA), with… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.10, pp. 3157-3157, 2025, DOI:10.32604/or.2025.073033 - 26 September 2025

Abstract This article has no abstract. More >

Tri Susanti^1,2, Syahnur Haqiqoh¹, Pratiwi Pudjiastuti^2,*, Siti Wafiroh^2,*, Esti Hendradi³, Oktavia Eka Puspita⁴, Nashriq Jailani⁵

Journal of Renewable Materials, Vol.13, No.9, pp. 1841-1857, 2025, DOI:10.32604/jrm.2025.02024-0084 - 22 September 2025

Abstract This study aims to enhance the mechanical properties, disintegration, and dissolution rates of cross-linked carrageenan (CRG) capsule shells by shortening the long chains of CRG through a hydrolysis reaction with citric acid (CA). The hydrolysis of CRG was carried out using varying concentrations of CA, resulting in hydrolyzed CRG (HCRG). This was followed by cross-linking with xanthan gum (XG) and the addition of sorbitol (SOR) as a plasticizer. The results indicated that the optimal swelling capacity of HCRG-XG/SOR hard-shell capsules occurred at a CA concentration of 0.5%, achieving a maximum swelling rate of 445.39% after… More >

Sumeyra Ucar¹, Muhammed Aldaif ², Esra Yaprak¹, Esma Yigider ², Murat Aydin^2,*, Emre Ilhan¹, Abdulkadir Ciltas², Ertan Yildirim³

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2461-2477, 2025, DOI:10.32604/phyton.2025.068383 - 29 August 2025

Abstract Wheat is a crucial crop for global food security, and effective in vitro plant regeneration techniques are considered a precondition for genetic engineering in wheat breeding programs. A practical approach for in vitro regeneration of the Kırik bread wheat cultivar via somatic embryogenesis was investigated using endosperm-supported mature embryos. Callus cultures were initiated from mature embryos supported by endosperm, cultured on phytagel-based Murashige and Skoog (MS) basal medium containing dicamba (12 mg/L) and indole-3-acetic acid (IAA) (0.5 mg/L) under dark conditions. This research was designed to examine the impact of putrescine (Put) (0.0 and 1.0 mM) on… More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.8, pp. 2179-2179, 2025, DOI:10.32604/or.2025.070134 - 18 July 2025

Abstract This article has no abstract. More >

Ahmed Qasem^*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 809-824, 2025, DOI:10.32604/phyton.2025.062683 - 31 March 2025

Abstract Pimpinella anisum, commonly known as anise, is generally used in both folk medicine and the culinary world. In traditional medicine, it is valued for its digestive, respiratory, and antispasmodic properties. This study aims to examine the volatile compounds and antibacterial effect of P. anisum essential oil (PAEO) as well as for the first time its genotoxicity employing both in vitro and computational approaches. Gas chromatography-mass spectrometry (GC-MS) analysis identified anethole as the principal compound, which comprises 92.47% of PAEO. PAEO was tested for its potential antibacterial properties against Bacillus subtilis ATCC 6633, Listeria innocua ATCC 33090, Staphylococcus aureus ATCC 29213, Klebsiella aerogenes… More >