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  • Open Access

    ARTICLE

    A Unified Feature Selection Framework Combining Mutual Information and Regression Optimization for Multi-Label Learning

    Hyunki Lim*

    CMC-Computers, Materials & Continua, Vol.87, No.1, 2026, DOI:10.32604/cmc.2025.074138 - 10 February 2026

    Abstract High-dimensional data causes difficulties in machine learning due to high time consumption and large memory requirements. In particular, in a multi-label environment, higher complexity is required as much as the number of labels. Moreover, an optimization problem that fully considers all dependencies between features and labels is difficult to solve. In this study, we propose a novel regression-based multi-label feature selection method that integrates mutual information to better exploit the underlying data structure. By incorporating mutual information into the regression formulation, the model captures not only linear relationships but also complex non-linear dependencies. The proposed… More >

  • Open Access

    ARTICLE

    Toward Secure and Auditable Data Sharing: A Cross-Chain CP-ABE Framework

    Ye Tian1,*, Zhuokun Fan1, Yifeng Zhang2

    CMC-Computers, Materials & Continua, Vol.87, No.1, 2026, DOI:10.32604/cmc.2025.073935 - 10 February 2026

    Abstract Amid the increasing demand for data sharing, the need for flexible, secure, and auditable access control mechanisms has garnered significant attention in the academic community. However, blockchain-based ciphertext-policy attribute-based encryption (CP-ABE) schemes still face cumbersome ciphertext re-encryption and insufficient oversight when handling dynamic attribute changes and cross-chain collaboration. To address these issues, we propose a dynamic permission attribute-encryption scheme for multi-chain collaboration. This scheme incorporates a multi-authority architecture for distributed attribute management and integrates an attribute revocation and granting mechanism that eliminates the need for ciphertext re-encryption, effectively reducing both computational and communication overhead. It More >

  • Open Access

    ARTICLE

    A Cooperative Hybrid Learning Framework for Automated Dandruff Severity Grading

    Sin-Ye Jhong1, Hui-Che Hsu1,2, Hsin-Hua Huang2, Chih-Hsien Hsia3,4,*, Yulius Harjoseputro2,5, Yung-Yao Chen2,*

    CMC-Computers, Materials & Continua, Vol.87, No.1, 2026, DOI:10.32604/cmc.2026.072633 - 10 February 2026

    Abstract Automated grading of dandruff severity is a clinically significant but challenging task due to the inherent ordinal nature of severity levels and the high prevalence of label noise from subjective expert annotations. Standard classification methods fail to address these dual challenges, limiting their real-world performance. In this paper, a novel, three-phase training framework is proposed that learns a robust ordinal classifier directly from noisy labels. The approach synergistically combines a rank-based ordinal regression backbone with a cooperative, semi-supervised learning strategy to dynamically partition the data into clean and noisy subsets. A hybrid training objective is… More >

  • Open Access

    ARTICLE

    A Retrospective Real-World Study: The Efficacy and Safety of Immune Checkpoint Inhibitors Combined with Chemoradiotherapy in Limited-Stage Small Cell Lung Cancer

    Ruoxue Cai1,#, Shuyi Hu2,#, Feiyang Li2, Huanhuan Sha3,*, Guoren Zhou2,*, Ying Fang3

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070893 - 19 January 2026

    Abstract Objective: To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer (LS-SCLC). We conducted this retrospective study to evaluate whether immunotherapy can achieve better efficacy in LS-SCLC patients. Methods: We evaluated 122 LS-SCLC patients who received concurrent chemoradiotherapy (CCRT) or sequential chemoradiotherapy (SCRT) (Group A) and immunotherapy combined with CCRT/SCRT followed by immunotherapy (Group B), to assess the objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS). Factors affecting prognosis were also explored using Cox analysis. The prognosis of patients with type 2 diabetes and patients with… More >

  • Open Access

    ARTICLE

    LUAR: Lightweight and Universal Attribute Revocation Mechanism with SGX Assistance towards Applicable ABE Systems

    Fei Tang1,*, Ping Wang1, Jiang Yu1, Huihui Zhu1, Mengxue Qin1, Ling Yang2

    CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073423 - 12 January 2026

    Abstract Attribute-Based Encryption (ABE) has emerged as a fundamental access control mechanism in data sharing, enabling data owners to define flexible access policies. A critical aspect of ABE is key revocation, which plays a pivotal role in maintaining security. However, existing key revocation mechanisms face two major challenges: (1) High overhead due to ciphertext and key updates, primarily stemming from the reliance on revocation lists during attribute revocation, which increases computation and communication costs. (2) Limited universality, as many attribute revocation mechanisms are tailored to specific ABE constructions, restricting their broader applicability. To address these challenges,… More >

  • Open Access

    ARTICLE

    Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes: A Real-World Data Cohort Study

    Cheng-Hsun Chuang1,2,3,#, Ping-Kun Tsai3,4,5,6,#, Shih-Wen Kao7,8, Yu-Hsun Wang8,9,*, Chao-Bin Yeh1,2,3,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072875 - 30 December 2025

    Abstract Background: To determine whether initiating a glucagon-like peptide-1 receptor agonist (GLP-1 RA) within 3 months of type 2 diabetes (T2DM) diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index (BMI). Methods: This retrospective cohort study used electronic health records from the TriNetX U.S. research network. Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis. Following 1:1 propensity score matching, both the GLP-1 RA user and non-user… More > Graphic Abstract

    Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes: A Real-World Data Cohort Study

  • Open Access

    ARTICLE

    Federated Multi-Label Feature Selection via Dual-Layer Hybrid Breeding Cooperative Particle Swarm Optimization with Manifold and Sparsity Regularization

    Songsong Zhang1, Huazhong Jin1,2,*, Zhiwei Ye1,2, Jia Yang1,2, Jixin Zhang1,2, Dongfang Wu1,2, Xiao Zheng1,2, Dingfeng Song1

    CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-19, 2026, DOI:10.32604/cmc.2025.068044 - 10 November 2025

    Abstract Multi-label feature selection (MFS) is a crucial dimensionality reduction technique aimed at identifying informative features associated with multiple labels. However, traditional centralized methods face significant challenges in privacy-sensitive and distributed settings, often neglecting label dependencies and suffering from low computational efficiency. To address these issues, we introduce a novel framework, Fed-MFSDHBCPSO—federated MFS via dual-layer hybrid breeding cooperative particle swarm optimization algorithm with manifold and sparsity regularization (DHBCPSO-MSR). Leveraging the federated learning paradigm, Fed-MFSDHBCPSO allows clients to perform local feature selection (FS) using DHBCPSO-MSR. Locally selected feature subsets are encrypted with differential privacy (DP) and transmitted… More >

  • Open Access

    REVIEW

    Polymeric Nanofiber Scaffolds for Diabetic Wound Healing: A Review

    Rafl M. Kamil1, Shaik Nyamathulla1,*, Syed Mahmood1,2,3,4,*

    Journal of Polymer Materials, Vol.42, No.4, pp. 959-992, 2025, DOI:10.32604/jpm.2025.072005 - 26 December 2025

    Abstract With the global diabetes epidemic, diabetic foot ulcers (DFUs) have become a major health burden, affecting approximately 18 million people worldwide each year, and account for about 80% of diabetes-related amputations. Five-year mortality among DFU patients approaches 30%, which is comparable to that of many malignancies. Yet despite standard wound care, only about 30%–40% of chronic DFUs achieve complete healing within 12 weeks. This persistent failure shows that conventional dressings remain passive supports. They do not counteract underlying pathologies such as ischemia, prolonged inflammation, and infection. Recent advances in polymeric nanofiber scaffolds, particularly electrospun matrices,… More > Graphic Abstract

    Polymeric Nanofiber Scaffolds for Diabetic Wound Healing: A Review

  • Open Access

    ARTICLE

    Enhancement of Medical Imaging Technique for Diabetic Retinopathy: Realistic Synthetic Image Generation Using GenAI

    Damodharan Palaniappan1, Tan Kuan Tak2, K. Vijayan3, Balajee Maram4, Pravin R Kshirsagar5, Naim Ahmad6,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4107-4127, 2025, DOI:10.32604/cmes.2025.073387 - 23 December 2025

    Abstract A phase-aware cross-modal framework is presented that synthesizes UWF_FA from non-invasive UWF_RI for diabetic retinopathy (DR) stratification. A curated cohort of 1198 patients (2915 UWF_RI and 17,854 UWF_FA images) with strict registration quality supports training across three angiographic phases (initial, mid, final). The generator is based on a modified pix2pixHD with an added Gradient Variance Loss to better preserve microvasculature, and is evaluated using MAE, PSNR, SSIM, and MS-SSIM on held-out pairs. Quantitatively, the mid phase achieves the lowest MAE (98.76 ± 42.67), while SSIM remains high across phases. Expert review shows substantial agreement (Cohen’s More >

  • Open Access

    ARTICLE

    PPG Based Digital Biomarker for Diabetes Detection with Multiset Spatiotemporal Feature Fusion and XAI

    Mubashir Ali1,2, Jingzhen Li1, Zedong Nie1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4153-4177, 2025, DOI:10.32604/cmes.2025.073048 - 23 December 2025

    Abstract Diabetes imposes a substantial burden on global healthcare systems. Worldwide, nearly half of individuals with diabetes remain undiagnosed, while conventional diagnostic techniques are often invasive, painful, and expensive. In this study, we propose a noninvasive approach for diabetes detection using photoplethysmography (PPG), which is widely integrated into modern wearable devices. First, we derived velocity plethysmography (VPG) and acceleration plethysmography (APG) signals from PPG to construct multi-channel waveform representations. Second, we introduced a novel multiset spatiotemporal feature fusion framework that integrates hand-crafted temporal, statistical, and nonlinear features with recursive feature elimination and deep feature extraction using… More >

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