Jun Li¹, Chunyan Liang^1,*, Zhiguo Liu¹, Fengpei Ge²

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.071011 - 12 January 2026

Abstract To enhance speech emotion recognition capability, this study constructs a speech emotion recognition model integrating the adaptive acoustic mixup (AAM) and improved coordinate and shuffle attention (ICASA) methods. The AAM method optimizes data augmentation by combining a sample selection strategy and dynamic interpolation coefficients, thus enabling information fusion of speech data with different emotions at the acoustic level. The ICASA method enhances feature extraction capability through dynamic fusion of the improved coordinate attention (ICA) and shuffle attention (SA) techniques. The ICA technique reduces computational overhead by employing depth-separable convolution and an h-swish activation function and More >

Tsu-Yang Wu¹, Chengyuan Yu¹, Yanan Zhao², Saru Kumari³, Chien-Ming Chen^1,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.069139 - 12 January 2026

Abstract With the increasing complexity of logistics operations, traditional static vehicle routing models are no longer sufficient. In practice, customer demands often arise dynamically, and multi-depot systems are commonly used to improve efficiency. This paper first introduces a vehicle routing problem with the goal of minimizing operating costs in a multi-depot environment with dynamic demand. New customers appear in the delivery process at any time and are periodically optimized according to time slices. Then, we propose a scheduling system TS-DPU based on an improved ant colony algorithm TS-ACO to solve this problem. The classical ant colony More >

Luksamee Vittaya^1,*, Chakhriya Chalad¹, Sittichoke Janyong², Nararak Leesakul³

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 4091-4115, 2025, DOI:10.32604/phyton.2025.074891 - 29 December 2025

Abstract Calophyllum inophyllum is a tropical plant that could have useful medicinal properties for pharmaceutical and cosmetic applications. The present study extracted the flower, fruit, leaf, twig, and bark of the plant by maceration in different organic solvents. The correlation between bioactive compounds and their biological activities was investigated, with emphasis on their therapeutic relevance through in silico pharmacokinetic predictions using SwissADME. Qualitative and quantitative analyses were conducted to determine the total phenolic, flavonoid, and saponin contents of the extracts. Spectral analysis of the extracts revealed –OH, C=O, C=C, and C–H functional groups. The antioxidant activity of the… More > Graphic Abstract

Oleh Koshovyi¹, Amal D. Premarathna², Rando Tuvikene², Valdas Jakštas^3,4, Vaidotas Žvikas³, Yurii Hrytsyk⁵, Lyubov Grytsyk⁵, Andriy Grytsyk⁵, Jaan Liira⁶, Ain Raal^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3991-4019, 2025, DOI:10.32604/phyton.2025.074153 - 29 December 2025

Abstract Gilia capitata Sims (Polemoniaceae) is an annual herbaceous plant widely distributed in western North America and cultivated as an ornamental flower. The detailed chemical composition and pharmacological properties of this plant have not been previously reported. This study aimed to investigate the chemical composition and pharmacological activity of aqueous-ethanolic extracts derived from different plant parts (herb, flowers, stems, roots, and fruits). HPLC analysis identified 12 phenolic compounds and 16 amino acids in the aqueous-ethanolic extracts obtained from these plant parts. The biological effects of the extracts were evaluated in vitro, including cytotoxicity, anti-inflammatory response, and wound-healing potential.… More >

Virna Margarita Martín Giménez¹, SebastiáN GarcíA MenéNdez^2,3, Luiz Gustavo A. Chuffa⁴, Vinicius Augusto SimãO⁴, Russel J. Reiter⁵, Ramaswamy Sharma⁶, Walter Balduini⁷, Carla Gentile⁸, Walter Manucha^2,3,*

BIOCELL, Vol.49, No.12, pp. 2245-2282, 2025, DOI:10.32604/biocell.2025.071830 - 24 December 2025

Abstract Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are characterized by progressive neuronal loss, which is closely linked to mitochondrial dysfunction. These pathologies involve a complex interplay of genetics, protein misfolding, and cellular stress, culminating in impaired energy metabolism, an increase in reactive oxygen species (ROS), and defective mitochondrial quality control. The accumulation of damaged mitochondria and dysregulation of pathways such as the Integrated Stress Response (ISR) are central to the pathogenesis of these conditions. This review explores the critical relationship between mitochondrial stress… More >

Mohd Hakimi Abdul Rahman¹, Amir Sharifuddin Ab Latip^1,*, Zulkiflee Abd Latif^1,2, Siti Balqis Mohd Tun¹, Nur Azlina Hariffin¹, Mohd Fikri Razali³

Revue Internationale de Géomatique, Vol.34, pp. 959-972, 2025, DOI:10.32604/rig.2025.071109 - 12 December 2025

Abstract Atmospheric phase delay, primarily caused by water vapor in the troposphere, is a major source of error in InSAR measurements, especially for land subsidence monitoring. This study integrates GNSS and GACOS data to correct tropospheric delay and enhance InSAR accuracy in Banting, Selangor. A total of 27 Sentinel-1A images, 14 GNSS stations, and 27 corresponding GACOS ZTD maps were used to monitor subsidence between 2023 and 2025. The InSAR data were processed using SNAP, StaMPS, and the TRAIN toolbox, incorporating both GNSS- and GACOS-derived ZTD corrections. The results show that applying atmospheric correction improved the… More >

Ruikang Ma^1,2, Ziying Huang¹, Zexiu Zhang³, Ruohui Lu⁴, Menghan Li¹, Zhiyi Luo³, Mengni Li⁵, Pengyue Zhang³, Xiaohong Lin³, Guozhuang Zhang^1,*, Linlin Dong^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3721-3748, 2025, DOI:10.32604/phyton.2025.072062 - 01 December 2025

Abstract Dendrobium officinale (DO) is a well-recognized medicinal and edible plant with a long history of application in traditional medicinal practices across China and Southeast Asia. Recent studies have demonstrated that DO is abundant in diverse bioactive compounds, including polysaccharides (DOP), flavonoids, alkaloids, and bibenzyls thought to exert a range of pharmacological effects, such as anti-tumor and immunomodulatory effects. However, our comprehensive understanding of two key aspects—pharmacological functions and biosynthetic mechanisms—of DO’s major constituents remains limited, especially when considered within the clinical contexts of traditional use. To address this gap, this study reviews DO’s historical applications, clinical effects, and… More > Graphic Abstract

Yousra Hammouti^1,2,*, François Mesnard², Oussama Khibech³, Mohamed Taibi¹, Yousra Belbachir³, El Hassania Loukili⁴, Reda Bellaouchi⁵, Abdeslam Asehraou⁵, Mohamed Addi^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3563-3583, 2025, DOI:10.32604/phyton.2025.071139 - 01 December 2025

Abstract Centaurium erythraea Rafn (“Gosset El Haya”) has long been prized in North African folk medicine, yet Moroccan chemobiological data remain scarce. Ethanol extracts of northern Moroccan aerial parts were profiled by high-performance liquid chromatography (HPLC) and found rich in phenolics, dominated by 4-hydroxybenzoic acid (57.8%) and naringin (10.3%). The extract exhibited strong antioxidant power in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, with a half-maximal inhibitory concentration (IC₅₀) of ≈74 µg mL⁻¹, and a total antioxidant capacity (TAC) of ≈201 µg mL⁻¹ and selective antimicrobial activity, sharply inhibiting Aspergillus niger, Penicillium digitatum, and Rhodotorula glutinis while sparing Staphylococcus aureus. In-silico absorption, distribution, metabolism,… More >

Jun He¹, Jianli Luo¹, Yanling Wang^1,*, Dai Zhou^1,*, Shuanglin Xiang^2,*

Congenital Heart Disease, Vol.20, No.5, pp. 613-623, 2025, DOI:10.32604/chd.2025.071773 - 30 November 2025

Abstract Pediatric congenital heart disease (CHD) pharmacotherapy faces three fundamental barriers: developmental pharmacokinetic complexity, anatomic-genetic heterogeneity, and evidence chain gaps. Traditional agents exhibit critical limitations: digoxin’s narrow therapeutic index (0.5–0.9 ng/mL) is exacerbated by ABCB1 mutations (toxicity risk increases 4.1-fold), furosemide efficacy declines by 35% in neonates due to NKCC2 immaturity, and β-blocker responses vary by CYP2D6 polymorphisms (poor metabolizers require 50–75% dose reduction). Novel strategies demonstrate transformative potential—CRISPR editing achieves 81% reversal of BMPR2-associated pulmonary vascular remodeling, metabolically matured cardiac organoids replicate adult myocardial energy metabolism for drug screening, and SGLT2 inhibitors activate triple mechanisms (calcium overload More >

Mudasir Ali¹, Muhammad Faheem Mushtaq², Urooj Akram², Nagwan Abdel Samee^3,*, Mona M. Jamjoom⁴, Imran Ashraf^5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 1863-1901, 2025, DOI:10.32604/cmes.2025.070389 - 26 November 2025

Abstract Differentiating between regular and abnormal noises in machine-generated sounds is a crucial but difficult problem. For accurate audio signal classification, suitable and efficient techniques are needed, particularly machine learning approaches for automated classification. Due to the dynamic and diverse representative characteristics of audio data, the probability of achieving high classification accuracy is relatively low and requires further research efforts. This study proposes an ensemble model based on the LeNet and hierarchical attention mechanism (HAM) models with MFCC features to enhance the models’ capacity to handle bias. Additionally, CNNs, bidirectional LSTM (BiLSTM), CRNN, LSTM, capsule network More >