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  • Open Access


    Aerodynamic Analysis and Optimization of Pantograph Streamline Fairing for High-Speed Trains

    Xiang Kan1, Yan Li2, Tian Li1,*, Jiye Zhang1

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1075-1091, 2024, DOI:10.32604/fdmp.2023.044050

    Abstract A pantograph serves as a vital device for the collection of electricity in trains. However, its aerodynamic resistance can limit the train’s running speed. As installing fairings around the pantograph is known to effectively reduce the resistance, in this study, different fairing lengths are considered and the related aerodynamic performances of pantograph are assessed. In particular, this is accomplished through numerical simulations based on the k-ω Shear Stress Transport (SST) two-equation turbulence model. The results indicate that the fairing diminishes the direct impact of high-speed airflow on the pantograph, thereby reducing its aerodynamic resistance. However, it More >

  • Open Access


    Induction of Multidrug Resistance of Acute Myeloid Leukemia Cells by Cocultured Stromal Cells via Upregulation of the PI3K/Akt Signaling Pathway

    Ping Chen*, Qing Jin*, Qiang Fu*, Peidong You*, Xi Jiang*, Qin Yuan*, Huifang Huang

    Oncology Research, Vol.24, No.4, pp. 215-223, 2016, DOI:10.3727/096504016X14634208143021

    Abstract This study aimed to investigate the role of the PI3K/Akt signaling pathway in multidrug resistance of acute myeloid leukemia (AML) cells induced by cocultured stromal cells. Human AML cell lines HL-60 and U937 were adhesion cocultured with human bone marrow stromal cell line HS-5 cells. Such coculturing induced HL-60 and U937 cells resistant to chemotherapeutic drugs including daunorubicin (DNR), homoharringtonine (HHT), and cytosine arabinoside (Ara-C). The coculturing-induced resistance of AML cells to DNR, HHT, and Ara-C can be partially reversed by inhibition of the PI3K/Akt signaling pathway. Clinically, AML patients with a low level of More >

  • Open Access


    miR-34b Targets HSF1 to Suppress Cell Survival in Acute Myeloid Leukemia

    Gangcan Li, Yanping Song, Yunjie Zhang, Hao Wang, Jia Xie

    Oncology Research, Vol.24, No.2, pp. 109-116, 2016, DOI:10.3727/096504016X14611963142254

    Abstract Acute myeloid leukemia (AML) is the most lethal hematological malignancy, and the occurrence of chemoresistance prevents the achievement of complete remission following the standard therapy. MicroRNAs have been extensively investigated as critical regulators of hematopoiesis and leukemogenesis, and they represent a promising strategy for AML therapy. In this study, we identified miR-34b as a novel regulator in myeloid proliferation and apoptosis of leukemic cells. We found that miR-34b was developmentally upregulated in plasma and myeloid cells of healthy subjects, while it was significantly reduced in blood samples of patients with AML and AML cell lines.… More >

  • Open Access


    Mitoxantrone and Etoposide for the Treatment of Acute Myeloid Leukemia Patients in First Relapse

    Annie Im, Ali Amjad, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Seah Lim, Alison Sehgal, Kathleen A. Dorritie, Robert L. Redner, Brian McLaughlin, Yongli Shuai, Shrina Duggal, Michael Boyiadzis

    Oncology Research, Vol.24, No.2, pp. 73-80, 2016, DOI:10.3727/096504016X14586627440156

    Abstract Relapsed acute myeloid leukemia (AML) represents a major therapeutic challenge. Achieving complete remission (CR) with salvage chemotherapy is the first goal of therapy for relapsed AML. However, there is no standard salvage chemotherapy. The current study evaluated outcomes and prognostic factors for achievement of CR in 91 AML patients in first relapse who were treated with the mitoxantrone–etoposide combination regimen. The overall response rate (CR and CRi) was 25%. Factors that were associated with a lower rate of CR included older age, shorter duration of first CR, low hemoglobin, and low platelet count. The median… More >

  • Open Access


    miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia

    Yueli Gu*, Jinchun Si, Xichun Xiao*, Ying Tian*, Shuo Yang*

    Oncology Research, Vol.25, No.7, pp. 1069-1079, 2017, DOI:10.3727/096504016X14829256525028

    Abstract Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was remarkably upregulated in AML cell lines HL-60 and THP-1. Dual luciferase reporter assay revealed that MTHFD2 was a direct target of miR-92a. Gain- and loss-of-function analysis demonstrated that MTHFD2 knockdown or miR-92a overexpression notably inhibited proliferation and promoted apoptosis of AML cell lines. Restoration of MTHFD2 expression reversed proliferation inhibition and apoptosis induction of More >

  • Open Access


    Model Agnostic Meta-Learning (MAML)-Based Ensemble Model for Accurate Detection of Wheat Diseases Using Vision Transformer and Graph Neural Networks

    Yasir Maqsood1, Syed Muhammad Usman1,*, Musaed Alhussein2, Khursheed Aurangzeb2,*, Shehzad Khalid3, Muhammad Zubair4

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2795-2811, 2024, DOI:10.32604/cmc.2024.049410

    Abstract Wheat is a critical crop, extensively consumed worldwide, and its production enhancement is essential to meet escalating demand. The presence of diseases like stem rust, leaf rust, yellow rust, and tan spot significantly diminishes wheat yield, making the early and precise identification of these diseases vital for effective disease management. With advancements in deep learning algorithms, researchers have proposed many methods for the automated detection of disease pathogens; however, accurately detecting multiple disease pathogens simultaneously remains a challenge. This challenge arises due to the scarcity of RGB images for multiple diseases, class imbalance in existing… More >

  • Open Access


    Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia


    Oncology Research, Vol.32, No.3, pp. 577-584, 2024, DOI:10.32604/or.2023.043026

    Abstract Background: microRNA-34a (miR-34a) had been reported to have a diagnostic role in acute myeloid leukemia (AML). However, its value in the bone marrow (BM) of AML patients, in addition to its role in response to therapy is still unclear. The current study was designed to assess the diagnostic, prognostic, and predictive significance of miR-34a in the BM of AML patients. Methods: The miR-34a was assessed in BM aspirate of 82 AML patients in relation to 12 normal control subjects using qRT-PCR. The data were assessed for correlation with the relevant clinical criteria, response to therapy,… More >

  • Open Access



    Emad D. Aboud1 , Qusay Rasheed Al-Amir2, Hameed K. Hamzah2, Ammar Abdulkadhim3, Mustafa M. Gabir3, Salwan Obaid Waheed Khafaji2, Farooq H. Ali2,*

    Frontiers in Heat and Mass Transfer, Vol.17, pp. 1-17, 2021, DOI:10.5098/hmt.17.19

    Abstract The natural convection of nanofluid flow, which occurs between a sinusoidal-corrugated enclosure and a concentric inner cylinder has been numerically investigated. The two horizontal walls of this enclosure are considered adiabatic and two vertical corrugated walls are held at a constant value of the cold temperature while the inner concentric cylinder is heated isothermally. Different cylinder geometries (i.e, circular, square, rhombus, and triangular) located inside the enclosure are examined to find the best shape for optimum heat transfer. The physical and geometrical parameters influencing heat transfer are Rayleigh number (Ra=103 -106), undulation numbers (N=0,1 and 2),… More >

  • Open Access


    Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.: A review


    BIOCELL, Vol.47, No.5, pp. 1159-1176, 2023, DOI:10.32604/biocell.2023.022065

    Abstract Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese Medicines. For several decades, the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, anemia, anorexia, and dyspepsia. In the traditional system, Indian gooseberry has various ethnomedicinal applications. In the Ayurvedic system, different methods of administration (anupan) have shown different ethnomedicinal properties of Indian gooseberry. Seventy well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation, among which the flavonoids and phenols are most prominent. From the toxicity perspective,… More >

  • Open Access


    A Variational Multiscale Method for Particle Dispersion Modeling in the Atmosphere

    Y. Nishio1,*, B. Janssens1, K. Limam2, J. van Beeck3

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.3, pp. 743-753, 2023, DOI:10.32604/fdmp.2022.021848

    Abstract A LES model is proposed to predict the dispersion of particles in the atmosphere in the context of Chemical, Biological, Radiological and Nuclear (CBRN) applications. The code relies on the Finite Element Method (FEM) for both the fluid and the dispersed solid phases. Starting from the Navier-Stokes equations and a general description of the FEM strategy, the Streamline Upwind Petrov-Galerkin (SUPG) method is formulated putting some emphasis on the related assembly matrix and stabilization coefficients. Then, the Variational Multiscale Method (VMS) is presented together with a detailed illustration of its algorithm and hierarchy of computational More >

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