Yan Li¹, Bailong Sun², Tian Li^2,*, Weihua Zhang²

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 1957-1970, 2025, DOI:10.32604/cmes.2025.069159 - 31 August 2025

Abstract High-speed maglev trains represent a key direction for the future development of rail transportation. As operating speeds increase, they face increasingly severe aerodynamic challenges. The streamlined aerodynamic shape of a maglev train is a critical factor influencing its aerodynamic performance, and optimizing its length plays a significant role in improving the overall aerodynamic characteristics of the train. In this study, a numerical simulation model of a high-speed maglev train was established based on computational fluid dynamics (CFD) to investigate the effects of streamline length on the aerodynamic performance of the train operating on an open… More >

Kelvin Kang Wee Tang^1,*, Muhammad Hafiz Mohd Yatim¹, Norhadija Darwin², Wan Anom Wan Aris¹, Sim Ching Yen³, Nurfazira Mohamed Fadil³

Revue Internationale de Géomatique, Vol.34, pp. 587-602, 2025, DOI:10.32604/rig.2025.065583 - 06 August 2025

Abstract The integration of Unmanned Aerial Vehicles (UAVs) and Uncrewed Surface Vehicles (USVs) has revolutionized topographic and bathymetric mapping, significantly enhancing the accuracy and efficiency of geospatial data acquisition processes. This innovative approach synergistically combines terrestrial data collected by UAVs with underwater data obtained through USVs, culminating in the creation of unified high-resolution Digital Elevation Models (DEMs) of the river basin region represents a vital step toward understanding the dynamic interactions between land and water bodies. Hence, the seamless Topo-Bathymetric Elevation Model offers a detailed perspective of the river system, supporting informed decision-making in addressing sediment… More >

Fatma S. Alrayes¹, Syed Umar Amin^2,*, Nada Ali Hakami², Mohammed K. Alzaylaee³, Tariq Kashmeery⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 581-614, 2025, DOI:10.32604/cmes.2025.065188 - 31 July 2025

Abstract The growing incidence of cyberattacks necessitates a robust and effective Intrusion Detection Systems (IDS) for enhanced network security. While conventional IDSs can be unsuitable for detecting different and emerging attacks, there is a demand for better techniques to improve detection reliability. This study introduces a new method, the Deep Adaptive Multi-Layer Attention Network (DAMLAN), to boost the result of intrusion detection on network data. Due to its multi-scale attention mechanisms and graph features, DAMLAN aims to address both known and unknown intrusions. The real-world NSL-KDD dataset, a popular choice among IDS researchers, is used to… More >

BHAVYADHARSHINI ARUN^1,#, PRARTHANA GOPINATH^1,2,#, ANUP JHA^1,3, NISHTHA TRIPATHI¹, SYED G DASTAGER^4,*, SYED K HASAN^1,3,*

Oncology Research, Vol.33, No.8, pp. 2161-2174, 2025, DOI:10.32604/or.2025.062951 - 18 July 2025

Abstract Background: Acute Myeloid Leukemia (AML) is a highly aggressive clonal hematological malignancy with limited treatment options. This study aimed to evaluate the therapeutic potential of nigericin, a polyether ionophore derived from Streptomyces DASNCL-29, as a mitochondrial-targeted agent for AML treatment. Methods: Nigericin was isolated from Streptomyces DASNCL-29 and characterized via chromatography and NMR. Its cytotoxicity was tested in MOLM13 (sensitive and venetoclax-resistant) and HL60 (sensitive and cytarabine-resistant) cells using the MTT assay. Mitochondrial dysfunction was assessed by measuring reactive oxygen species (ROS), mitochondrial membrane potential (Δψm), and mitochondrial mass. Apoptosis was evaluated with Annexin V/PI assays… More > Graphic Abstract

Jingxiang Zhou¹, Qiaoling Zhou^1,*, Chunlian Liang¹, Yulu Guo¹, Zhao Xiao², Yingfeng Xu¹

Structural Durability & Health Monitoring, Vol.19, No.4, pp. 953-983, 2025, DOI:10.32604/sdhm.2024.058501 - 30 June 2025

Abstract Streamlined box girders serve as a prevalent choice for the primary structural elements in large-span suspension bridge designs. With the increase in traffic demands, the design of such girders is evolving towards wider bridge decks and larger aspect ratios (B/D). To obtain more effective and aerodynamic design shapes for streamlined box girders, it is essential to investigate the impact of B/D on their aerodynamic performance. Accordingly, in this study we investigate the buffeting responses of large-span suspension bridges using girders of varying aspect ratios (B/D of 7.5, 9.3, and 12.7). First, the aerodynamic coefficients… More >

YULIAN WANG¹, LIANLI ZHU¹, RONGHAO ZENG², YUNPING PU³, BAIJIAN CHEN³, YUWEI TAN³, MING HONG^2,*, WEIJIA WANG^1,2,*

Oncology Research, Vol.33, No.3, pp. 695-708, 2025, DOI:10.32604/or.2024.051746 - 28 February 2025

Abstract Background: The role of 1,25-dihydroxyvitamin D3 (1,25-(OH)₂D₃) in cancer prevention and treatment is an emerging topic of interest. However, its effects on the stemness of acute myeloid leukemia (AML) cells are poorly understood. Methods: The proliferation and differentiation of AML cells (HL60 and NB4) were investigated by the CCK-8 assay, immunocytochemical staining, and flow cytometry. The abilities of HL60 and NB4 cells to form spheres were examined by the cell sphere formation assay. In addition, the levels of stemness-associated markers (SOX2, Nanog, OCT4, and c-Myc) in HL60 and NB4 cells were measured by western blotting and… More >

Chao Zhou¹, Narisu Wang¹, Fuyin Ni^1,2,*, Wenchao Zhang¹

Energy Engineering, Vol.122, No.1, pp. 265-284, 2025, DOI:10.32604/ee.2024.057380 - 27 December 2024

Abstract Uneven power distribution, transient voltage, and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes. In response to these issues, this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization algorithm. The proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop control. Then, it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control strategy. Precise pre-synchronization is achieved by regulating the virtual current to zero and… More >

Xiang Kan¹, Yan Li², Tian Li^1,*, Jiye Zhang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1075-1091, 2024, DOI:10.32604/fdmp.2023.044050 - 07 June 2024

Abstract A pantograph serves as a vital device for the collection of electricity in trains. However, its aerodynamic resistance can limit the train’s running speed. As installing fairings around the pantograph is known to effectively reduce the resistance, in this study, different fairing lengths are considered and the related aerodynamic performances of pantograph are assessed. In particular, this is accomplished through numerical simulations based on the k-ω Shear Stress Transport (SST) two-equation turbulence model. The results indicate that the fairing diminishes the direct impact of high-speed airflow on the pantograph, thereby reducing its aerodynamic resistance. However, it More >

Yasir Maqsood¹, Syed Muhammad Usman^1,*, Musaed Alhussein², Khursheed Aurangzeb^2,*, Shehzad Khalid³, Muhammad Zubair⁴

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2795-2811, 2024, DOI:10.32604/cmc.2024.049410 - 15 May 2024

Abstract Wheat is a critical crop, extensively consumed worldwide, and its production enhancement is essential to meet escalating demand. The presence of diseases like stem rust, leaf rust, yellow rust, and tan spot significantly diminishes wheat yield, making the early and precise identification of these diseases vital for effective disease management. With advancements in deep learning algorithms, researchers have proposed many methods for the automated detection of disease pathogens; however, accurately detecting multiple disease pathogens simultaneously remains a challenge. This challenge arises due to the scarcity of RGB images for multiple diseases, class imbalance in existing… More >

MONA S. ABDELLATEIF^1,*, NAGLAA M. HASSAN², MAHMOUD M. KAMEL², YOMNA M. EL-MELIGUI²

Oncology Research, Vol.32, No.3, pp. 577-584, 2024, DOI:10.32604/or.2023.043026 - 06 February 2024

Abstract Background: microRNA-34a (miR-34a) had been reported to have a diagnostic role in acute myeloid leukemia (AML). However, its value in the bone marrow (BM) of AML patients, in addition to its role in response to therapy is still unclear. The current study was designed to assess the diagnostic, prognostic, and predictive significance of miR-34a in the BM of AML patients. Methods: The miR-34a was assessed in BM aspirate of 82 AML patients in relation to 12 normal control subjects using qRT-PCR. The data were assessed for correlation with the relevant clinical criteria, response to therapy,… More >