AHMED M. ELSHAZLY^1,2, TUONG VI V. NGUYEN¹, DAVID A. GEWIRTZ^1,*

Oncology Research, Vol.30, No.1, pp. 1-12, 2022, DOI:10.32604/or.2022.026459

Abstract PARP inhibitors have proven to be effective in conjunction with conventional therapeutics in the treatment of various solid as well as hematologic malignancies, particularly when the tumors are deficient in DNA repair pathways. However, as the case with other chemotherapeutic agents, their effectiveness is often compromised by the development of resistance. PARP inhibitors have consistently been reported to promote autophagy, a process that maintains cellular homeostasis and acts as an energy source by the degradation and reutilization of damaged subcellular organelles and proteins. Autophagy can exhibit different functional properties, the most prominent being cytoprotective. In addition, both cytotoxic and non-protective… More >

Jin Huang^1,2,#, Jixiang Sun^1,3,4,#, Kai Shao^1,3,4, Yamei Lin^1,3,4, Zhiguo Liu^1,3,4,*, Yujie Fu¹, Liqiang Mu^2,*

Journal of Renewable Materials, Vol.11, No.4, pp. 1807-1821, 2023, DOI:10.32604/jrm.2023.023721

Abstract Nanoparticles (NPs) have already been widely used in catalysis, antibacterial and coating fields. Compared with the traditional toxic and harmful reducing reagents, green synthesis of NPs by using plant extracts is not only environmental-friendly and cost-effective but also conducive to the multi-level and efficient utilization of wild plant resources. In this study, the aqueous extracts from Sorbus pohuashanensis (SP) and Aronia melanocarpa (AM) fruits were used as the reducing and protective reagents for synthesizing Au/AgNPs, with the characteristics of originality operation and high repeatability. The SP/AM fruit extracts functionalized Au/AgNPs were characterized by UV-vis spectroscopy (UV-vis), transmission electron microscopy (TEM),… More > Graphic Abstract

Rita Yi Man Li¹, Lingxi Song², Bo Li^2,3, M. James C. Crabbe^4,5,6, Xiao-Guang Yue^7,*

CMES-Computer Modeling in Engineering & Sciences, Vol.134, No.3, pp. 2247-2282, 2023, DOI:10.32604/cmes.2022.020930

Abstract The aims of this study were threefold: 1) study the research gap in carpark and price index via big data and natural language processing, 2) examine the research gap of carpark indices, and 3) construct carpark price indices via repeat sales methods and predict carpark indices via the AutoML. By researching the keyword “carpark” in Google Scholar, the largest electronic academic database that covers Web of Science and Scopus indexed articles, this study obtained 999 articles and book chapters from 1910 to 2019. It confirmed that most carpark research threw light on multi-storey carparks, management and ventilation systems, and reinforced… More > Graphic Abstract

T. Ganier, J. Hu, A. Pizzi^*

Journal of Renewable Materials, Vol.1, No.1, pp. 79-82, 2013, DOI:10.7569/JRM.2012.634101

Abstract Linear vibration welding of extractive rich Paduk wood from central Africa containing a high proportion of a native mixture of water-insoluble extractives, or of low water solubility, has been shown to yield joints of much upgraded water resistance. This has been shown to be due to the protecting infl uence the extractives from the wood itself has on the welded interphase, due to their inherent water repellence. Joints of unusually high percentage wood failure but modest strength were obtained; Paduk wood brittleness apparently yielding weld line strengths always higher than that of the surrounding wood itself. This indicated that Paduk… More >

LAURA LAFON-HUGHES^1,2,*

BIOCELL, Vol.46, No.12, pp. 2531-2535, 2022, DOI:10.32604/biocell.2022.022713

Abstract Poly(ADP-ribose) (PAR) is a highly negatively charged polymer. PAR is synthesized by poly(ADP-ribose)polymerases (PARPs) and is involved in the assembly and stabilization of macromolecular complexes. Here, the presence and putative roles of poly(ADP-ribosyl)ation (PARylation) associated to adherens junctions (AJ) and the actin cytoskeleton in epithelial and Schwann cells, is reviewed. The hypothesis generated by analogy, stating that PAR is associated to AJ in other cell types, is postulated. According to this hypothesis, PAR associated to puncta adherentia in chemical synapses would participate in plasticity, learning and memory. In turn, PAR associated to fascia adherens in cardiomyocytes, would affect heart beating.… More >

Yueqiang Yu¹, Tingang Ma¹, Suling Wang^1,*, Minzheng Jiang¹, Yanling Guo^2,3, Ting Jiang^1,*, Shuaiqi Huang¹, Ziming Zheng¹, Bo Yan¹, Jiyuan Lv¹

Journal of Renewable Materials, Vol.11, No.1, pp. 333-347, 2023, DOI:10.32604/jrm.2022.022296

Abstract A calculation model of stress field in laser additive manufacturing of walnut shell composite powder (walnut shell/Co-PES powder) was established. The DFLUX subroutine was used to implement the moveable application of a double ellipsoid heat source by considering the mechanical properties varying with temperature. The stress field was simulated by the sequential coupling method, and the experimental results were in good accordance with the simulation results. In addition, the distribution and variation of stress and strain field were obtained in the process of laser additive manufacturing of walnut shell composite powder. The displacement of laser additive manufacturing walnut shell composite… More > Graphic Abstract

L. K. Shoba^1,*, P. Mohan Kumar²

Computer Systems Science and Engineering, Vol.44, No.1, pp. 613-628, 2023, DOI:10.32604/csse.2023.024449

Abstract Nowadays in the medical field, imaging techniques such as Optical Coherence Tomography (OCT) are mainly used to identify retinal diseases. In this paper, the Central Serous Chorio Retinopathy (CSCR) image is analyzed for various stages and then compares the difference between CSCR before as well as after treatment using different application methods. The first approach, which was focused on image quality, improves medical image accuracy. An enhancement algorithm was implemented to improve the OCT image contrast and denoise purpose called Boosted Anisotropic Diffusion with an Unsharp Masking Filter (BADWUMF). The classifier used here is to figure out whether the OCT… More >

Shinjin Kang¹, Soo Kyun Kim^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.1, pp. 219-237, 2022, DOI:10.32604/cmes.2022.018413

Abstract This paper proposes a methodology for using multi-modal data in gameplay to detect outlier behavior. The proposed methodology collects, synchronizes, and quantifies time-series data from webcams, mouses, and keyboards. Facial expressions are varied on a one-dimensional pleasure axis, and changes in expression in the mouth and eye areas are detected separately. Furthermore, the keyboard and mouse input frequencies are tracked to determine the interaction intensity of users. Then, we apply a dynamic time warp algorithm to detect outlier behavior. The detected outlier behavior graph patterns were the play patterns that the game designer did not intend or play patterns that… More >

Taemin Lee¹, Beomsik Kim², Sanghyun Seo³, Kyunghyun Yoon^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.3, pp. 1441-1457, 2022, DOI:10.32604/cmes.2022.018010

Abstract Painting is done according to the artist's style. The most representative of the style is the texture and shape of the brush stroke. Computer simulations allow the artist's painting to be produced by taking this stroke and pasting it onto the image. This is called stroke-based rendering. The quality of the result depends on the number or quality of this stroke, since the stroke is taken to create the image. It is not easy to render using a large amount of information, as there is a limit to having a stroke scanned. In this work, we intend to produce rendering… More >

Abdullah Alabdulatif¹, Syed Sajjad Hussain Rizvi^2,*

Intelligent Automation & Soft Computing, Vol.32, No.2, pp. 827-840, 2022, DOI:10.32604/iasc.2022.021879

Abstract Network intrusion detection is the pressing need of every communication network. Many network intrusion detection systems (NIDS) have been proposed in the literature to cater to this need. In recent literature, plug-and-play NIDS, Kitsune, was proposed in 2018 and greatly appreciated in the literature. The Kitsune datasets were divided into 70% training set and 30% testing set for machine learning algorithms. Our previous study referred that the variants of the Tree algorithms such as Simple Tree, Medium Tree, Coarse Tree, RUS Boosted, and Bagged Tree have reported similar effectiveness but with slight variation inefficiency. To further extend this investigation, we… More >