Yuanyuan Li1, Xingyue Wang1, Yucan Deng1, Runfang Tian1, Jinfeng Zhao1, Li Liu2,*, Panpan Sun3,*, Zhiguang Ping1,3,*
Congenital Heart Disease, Vol.20, No.6, pp. 717-727, 2025, DOI:10.32604/chd.2026.075611
- 10 February 2026
Abstract Background: Four-dimensional (4D) ultrasound is increasingly being used for prenatal diagnosis of congenital heart disease (CHD). We aimed to perform a systematic review and meta-analysis to evaluate its diagnostic accuracy for fetal CHD. Methods: This systematic review was conducted in accordance with the PRISMA-DTA guidelines. We systematically searched eight databases for studies published up to July 22, 2025. Data were extracted to calculate diagnostic accuracy metrics, study quality was assessed using QUADAS-2, and a bivariate random-effects model was used for the meta-analysis. Results: A total of 49 studies were included, comprising 45 retrospective and 4 prospective studies,… More >