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Search Results (23)
  • Open Access


    Enhanced Detection of Cerebral Atherosclerosis Using Hybrid Algorithm of Image Segmentation

    Shakunthala Masi*, Helenprabha Kuttiappan

    Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 733-744, 2023, DOI:10.32604/iasc.2023.025919

    Abstract In medical science for envisaging human body’s phenomenal structure a major part has been driven by image processing techniques. Major objective of this work is to detect of cerebral atherosclerosis for image segmentation application. Detection of some abnormal structures in human body has become a difficult task to complete with some simple images. For expounding and distinguishing neural architecture of human brain in an effective manner, MRI (Magnetic Resonance Imaging) is one of the most suitable and significant technique. Here we work on detection of Cerebral Atherosclerosis from MRI images of patients. Cerebral Atherosclerosis is… More >

  • Open Access


    Computer Aided Coronary Atherosclerosis Plaque Detection and Classification

    S. Deivanayagi1,*, P. S. Periasamy2

    Intelligent Automation & Soft Computing, Vol.34, No.1, pp. 639-653, 2022, DOI:10.32604/iasc.2022.025632

    Abstract Coronary artery disease (CAD) remains a major reason for increased mortality over the globe, comprising myocardial infarction and ischemic cardiomyopathy. The CAD is highly linked to coronary stenosis owing to the encumbrance of atherosclerotic plaques. Particularly, diversified atherosclerotic plaques are highly responsible for major cardiac adverse events over the calcified and non-calcified plaques. There, the recognition and classification of atherosclerotic plaques play a vital role to prevent and intervene in CAD. The process of detecting various class labels of the atherosclerotic plaques is significant to identify the disease at the earlier stages. Since several automated… More >

  • Open Access


    Metaheuristics with Deep Learning Empowered Biomedical Atherosclerosis Disease Diagnosis and Classification

    Areej A. Malibari1, Siwar Ben Haj Hassine2, Abdelwahed Motwakel3, Manar Ahmed Hamza3,*

    CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 2859-2875, 2022, DOI:10.32604/cmc.2022.026338

    Abstract Atherosclerosis diagnosis is an inarticulate and complicated cognitive process. Researches on medical diagnosis necessitate maximum accuracy and performance to make optimal clinical decisions. Since the medical diagnostic outcomes need to be prompt and accurate, the recently developed artificial intelligence (AI) and deep learning (DL) models have received considerable attention among research communities. This study develops a novel Metaheuristics with Deep Learning Empowered Biomedical Atherosclerosis Disease Diagnosis and Classification (MDL-BADDC) model. The proposed MDL-BADDC technique encompasses several stages of operations such as pre-processing, feature selection, classification, and parameter tuning. Besides, the proposed MDL-BADDC technique designs a More >

  • Open Access


    Upregulation of microRNA-451a improves endothelial cell function in atherosclerosis by direct targeting of macrophage migration inhibitory factor


    BIOCELL, Vol.45, No.4, pp. 995-1004, 2021, DOI:10.32604/biocell.2021.012851

    Abstract This study aims to detect the expression of selected circulating microRNAs (miRNA), including miRNA-451a, miRNA-486-5p and miR-10b-5p, and their prospective roles as biomarkers in patients with atherosclerosis. For this purpose, levels of miRNAs were detected by real-time quantitative polymerase chain reaction (RT-qPCR) in case (N = 30) and healthy control (N = 30) groups. Receiver operating characteristic (ROC) curve analysis was carried out to evaluate the diagnostic ability of miRNAs. The correlations of miR-451a with lipid parameters were evaluated using Pearson’s correlation coefficients. HUVEC tested by ox-LDL was used as a cellular model of atherosclerosis.… More >

  • Open Access


    Acquired Coronary Artery Disease in Patients with Congenital Heart Disease: Issues in Diagnosis and Management

    Sotiria C. Apostolopoulou1,*, Stella Brili2, Eftihia Sbarouni3, Dimitris Tousoulis2, Konstantinos Toutouzas2

    Congenital Heart Disease, Vol.15, No.5, pp. 369-375, 2020, DOI:10.32604/CHD.2020.012092

    Abstract Objective: Acquired coronary artery disease, initially thought to rarely affect survivors of congenital heart disease, is increasingly recognized in this population, as these patients grow in age and numbers in the recent era. This study reports our experience with coronary artery disease in adults with congenital heart disease and discusses treatment issues and the existing literature. Methods: Retrospective review of all charts of adults with congenital heart disease and acquired coronary artery disease was performed. Patients’ clinical characteristics, diagnosis, risk factors, noninvasive and invasive imaging and management data were recorded. Results: Coronary artery disease was diagnosed at… More >

  • Open Access


    The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis


    BIOCELL, Vol.44, No.3, pp. 337-344, 2020, DOI:10.32604/biocell.2020.011470

    Abstract This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival… More >

  • Open Access


    Exogenous dendritic cells aggravate atherosclerosis via P-selectin/ PSGL-1 pathway


    BIOCELL, Vol.44, No.2, pp. 225-236, 2020, DOI:10.32604/biocell.2020.08714

    Abstract Studies have found that a large number of inflammatory cells, P-selectin, and mature dendritic cells (DCs) are expressed in the damaged and shoulder parts of atherosclerotic plaque, which demonstrates that P-selectin and mature DCs participate in the immune inflammatory response leading to the development of atherosclerosis. However, it is unclear how the above factors interact in this setting. In this study, we investigated the role of P-selectin and its receptor, P-selectin glycoprotein ligand (PSGL)-1 in atherosclerosis, with the finding that DC surface marker expression was consistently high in the P-selectin group while consistently low in More >

  • Open Access


    Oscillatory Shear Stress Induces Endothelial Dysfunction through the Activation of P2Y12

    Jianxiong Xu1, Lu Wang1, Jinxuan Wang1, Juhui Qiu1,*, Guixue Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 142-142, 2019, DOI:10.32604/mcb.2019.07273

    Abstract Endothelial cell injured or dysfunction, which results lipid deposition and inflammation, is the key point to exacerbate the process of atherosclerosis [1, 2]. Meanwhile oscillatory shear stress is a key factor that results cell dysfunction in vascular disease [3, 4]. Previous research reported that P2Y12 plays a critical role in the development of atherosclerotic lesion through promoting smooth muscle cells migration [5]. As well P2Y12 stimulated the internalization and transendothelial transport of high density lipid. However, whether the P2Y12 induce atherosclerosis through endothelial cell remain elusive. In this study we firstly found P2Y12 were expressed… More >

  • Open Access


    Role of NFAT5 in Hypertonic Stress-Induced Atherosclerosis in Endothelium

    Pingping Ma1, Wanqian Liu1,*, Li Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 95-95, 2019, DOI:10.32604/mcb.2019.07363

    Abstract Globally, consumption of sodium (5.8 g per day) was far above the optimal levels (2.3 g per day). High intake of sodium was the leading dietary risk factor for deaths, which caused by cardiovascular disease [1]. Nevertheless, how high-salt intake leads to the occurrence of many cardiovascular diseases such as atherosclerosis is still not very clear. Dmitrieva has reported that elevated sodium concentration promoted thrombogenesis by activating the signal pathway of NFAT5 (nuclear factor of activated T cells 5), a transcription factor which orchestrates cellular defense against osmotic stress [2]. Inflammatory is accompanied with the… More >

  • Open Access


    Associations between Carotid Bifurcation Geometry and Atherosclerotic Plaque Vulnerability: A Chinese Atherosclerosis Risk Evaluation II Study

    Peirong Jiang1, Zhensen Chen2, Daniel S. Hippe2, Hiroko Watase3, Bin Sun1, Ruolan Lin1, Zheting Yang1, Yunjing Xue1,*, Xihai Zhao4,*, Chun Yuan2,4

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 34-35, 2019, DOI:10.32604/mcb.2019.07394

    Abstract This article has no abstract. More >

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