Katerina Basharova^1,2,#,*, Anastasia Bezrukova^1,2,#, Alena Kopytova^1,2, Anna Lavrinova^1,2, Galina Baydakova³, Irina Miliukhina^1,4, Ekaterina Zakharova^1,3, Anton Emelyanov^1,2, Sofya Pchelina^1,2, Tatiana Usenko^1,2,*

BIOCELL, Vol.50, No.8, 2026, DOI:10.32604/biocell.2026.079585 - 27 July 2026

Abstract Objectives: Synucleinopathies—Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA)—involve alpha-synuclein aggregation and lysosomal dysfunction. We conducted a longitudinal study of lysosomal hydrolase activities and lysosphingolipid levels in blood and PBMC-derived macrophages from patients, and assessed the effects of LRRK2 inhibition (MLi-2). Methods: Blood and PBMC-derived macrophages were collected from patients with idiopathic PD (iPD), DLB, MSA, and controls. Enzyme activities (GCase, ASMase, GLA, GALC) and lysosphingolipids (HexSph, LysoGb3, LysoSM) were measured. Autophagy markers (p62, LC3B-II) and cathepsin D (CTSD) were analyzed by western blot. Effects of MLi-2 were evaluated in macrophages. Results:… More >

Andrew Scarborough¹, Yvoni Kyriakidou¹, Derek C. Lee², Tomás Duraj², Thomas N. Seyfried², Isabella D. Cooper^1,*

BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.074152 - 09 June 2026

Abstract The global rise in chronic, non-communicable diseases (NCDs) is inextricably linked to metabolic dysfunction, with hyperinsulinaemia acting as a potent upstream driver of ageing and age-related disease. Some of the most burdensome diseases of our time, including type 2 diabetes, cardiovascular disease, cancer, and neurodegenerative conditions, such as Alzheimer’s disease (AD), are largely underpinned by insulin resistance as part of a broader system of metabolic and mitochondrial dysfunction. These pathologies are particularly pronounced in the developed world, where obesity and other lifestyle-related conditions are major contributors to disease burden and premature mortality. As an upstream… More >

Elena Matei^1,*, Ionuț Ciprian Iorga^2,3, Mariana Deacu^2,4, Georgeta Camelia Cozaru^1,4, Gabriela Isabela Băltățescu^1,4,#, Manuela Enciu^2,4,#

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.072421 - 21 May 2026

Abstract Objectives: Deregulated plasticity is involved in initiation, progression, metastasis, and resistance to therapy of various cancers. Our study aimed to present new checkpoints involved in complex biological processes that sustain epithelial-mesenchymal transition (EMT) variability and heterogeneity in prostate tumor cell plasticity. Methods: Dysregulated cell signaling pathways involved in prostate EMT heterogeneity were analyzed by intrinsic and extrinsic factors such as cell cycle phases by propidium iodide (PI) stain, apoptosis by caspase-3/7 biochemical cascade DEVDase enzyme activity by Magic Red stain (DEVD-MR)/propidium iodide stain, autophagy and nuclear shrinkage by Hoechst/acridine orange stain, evasion of immune surveillance by… More >

Zhiye Zhou^1,2, Jianan Chen³, Qiang Zhu^3,*

BIOCELL, Vol.50, No.5, 2026, DOI:10.32604/biocell.2026.076758 - 13 May 2026

Abstract Background: Human dental pulp stem cells (hDPSCs) are promising for dental tissue regeneration. Dioscin (Dio), a natural compound, has various biological activities, but its effects on hDPSCs are unclear. This study aims to systematically elucidate the effects of Dio on promoting the osteogenic differentiation of hDPSCs and the underlying molecular mechanisms. Methods: Characterized hDPSCs were treated with Dio. Cell viability, proliferation, osteogenic differentiation (alkaline phosphatase (ALP) activity, Alizarin Red S (ARS)), and migration (Transwell) were assessed. Mitophagy (fluorescence, Western blot for PTEN-induced kinase 1 (PINK1), parkin RBR E3 ubiquitin-protein ligase (PRKN), microtubule-associated protein 1 light chain… More > Graphic Abstract

Ralf Weiskirchen¹, Amedeo Lonardo^2,*

BIOCELL, Vol.50, No.5, 2026, DOI:10.32604/biocell.2026.076177 - 13 May 2026

Abstract Obesity is a complex chronic condition characterized by an excess of body fat that manifests in various clinical pathophenotypes, each affecting liver health differently. One significant cause of chronic liver diseases among those living with obesity is metabolic dysfunction-associated steatotic liver disease (MASLD), which is linked to one or more cardiometabolic risk factors in individuals who do not engage in harmful alcohol consumption. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is increasingly being associated with MASLD through intricate immunological, cellular, proinflammatory, molecular, and genetic mechanisms. In this review, we More > Graphic Abstract

Yiwei Hao^1,#, Yaodong Ping^2,#, Yan Yang³, Cheng Qu³, Yuan Chen¹, Xueyan Jiang¹, Rong Fu¹, Hailong Zhao^4,*, Lei Yu^4,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2025.074863 - 21 April 2026

Abstract Myocardial ischemia, a core pathological process underlying diverse cardiovascular diseases such as coronary artery disease, poses a severe threat to global human health by frequently leading to acute myocardial infarction, heart failure, and even sudden cardiac death. A comprehensive understanding of its intricate underlying pathogenic mechanisms is not only crucial for developing effective therapeutic strategies but also essential for accelerating the translation of basic research findings into clinical practice. However, the complex regulatory networks that drive myocardial ischemia remain to be systematically clarified. These networks encompass the intricate interactions among multiple pathological processes, including energy… More >

Jianfa Wu^1,2,3, Huang Chen³, Sihong Wang^1,2, Lei Peng^1,2, Xiaoying Hu^1,2, Zhou Liu^1,2,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070542 - 30 December 2025

Abstract Objectives: Ribosomal protein S6 kinase A2 (RPS6KA2) has been identified as a potential prognostic biomarker in several cancers, including breast cancer, glioblastoma, and prostate cancer. However, its functional significance in ovarian cancer is not well characterized. This study was designed to explore the therapeutic relevance of modulating RPS6KA2 in the context of ovarian cancer, particularly in relation to cisplatin resistance. Methods: The expression levels of RPS6KA2 and key regulators involved in autophagy and ferroptosis were assessed using quantitative reverse transcription-PCR, immunofluorescence staining, immunohistochemistry, and western blotting. Prognostic associations were conducted using the Kaplan-Meier Plotter database.… More >

Hong Wu, Yang Liu^*

BIOCELL, Vol.49, No.10, pp. 1985-2006, 2025, DOI:10.32604/biocell.2025.069527 - 22 October 2025

Abstract Background: Acute pancreatitis (AP) is a serious gastrointestinal disorder. Tetramethylpyrazine (TMP), a bioactive alkaloid extracted from Ligusticum chuanxiong, exhibits various pharmacological effects, but its protective mechanisms against AP remain unclear. This study aimed to investigate the protective effects and underlying mechanisms of TMP in AP. Methods: The study utilized Cerulein (CER) to model pancreatitis across experimental systems. Cellular responses were characterized through functional assays (CCK-8 viability, EdU proliferation, Transwell migration, flow cytometric apoptosis, Fluo-3/AM calcium imaging) and inflammatory profiling (ELISA for trypsin, CRP, TNF-α, IL-1β, IL-6). Autophagy was monitored via mRFP-GFP-LC3 flux and LysoTracker staining, with… More > Graphic Abstract

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.8, pp. 2177-2177, 2025, DOI:10.32604/or.2025.070133 - 18 July 2025

Abstract This article has no abstract. More >

Chuncheng Liu¹, Xiaohan Liu¹, Ziqi Li¹, Yanruoxue Wei¹, Bangdong Liu², Peng Zhu², Yukun Liu^1,2,*, Ran Zhao^1,2,*

Oncology Research, Vol.33, No.8, pp. 2085-2105, 2025, DOI:10.32604/or.2025.065739 - 18 July 2025

Abstract Background: VPS37A (VPS37A subunit of ESCRT-I), a component of the ESCRT-I (endosomal sorting complex required for transport I) complex, mediates vesicular trafficking through sorting endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Although accumulating evidence indicates that VPS37A deficiency occurs in numerous malignancies and exerts tumor-suppressive effects during cancer progression, its functional significance in colorectal cancer (CRC) pathogenesis remains poorly characterized. Therefore, this study aims to further investigate the functional and molecular mechanisms by which VPS37A downregulation contributes to malignant biological phenotypes in CRC, with a specific focus on how its dysregulation affects cell death pathways.… More > Graphic Abstract