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Search Results (73)
  • Open Access

    CORRECTION

    Correction: Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

    XIAOBI HUANG1, CHUNYUAN CHEN2, YONGYANG CHEN1, HONGLIAN ZHOU1, YONGHUA CHEN1, ZHONG HUANG1, YULIU XIE1, BAIYANG LIU1, YUDONG GUO1, ZHIXIONG YANG1, GUANGHUA CHEN3, WENMEI SU1,4

    Oncology Research, Vol.33, No.5, pp. 1249-1250, 2025, DOI:10.32604/or.2024.061822 - 18 April 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Mycobacterial antigen Ag85B restrains Hodgkin lymphoma tumor growth by inhibiting autophagy

    YONGFENG CHENG1, YIPING SHEN2, YUNFEI ZHANG1, HAILIQIGULI NURIDING1, XUEMEI WANG1, CHUNYAN FAN1, GULIBAHA MAIMAITI1, YU LIU1, YINGBIN YUE1, DANLU LI1, MEI YAN1,*

    Oncology Research, Vol.33, No.5, pp. 1173-1187, 2025, DOI:10.32604/or.2025.057842 - 18 April 2025

    Abstract Background: The growth of the B-cell lymphoma subtype, Hodgkin lymphoma (HL), is associated with increased autophagy. A mycobacterial antigen, Ag85, has been reported to inhibit cell autophagy under a variety of conditions. Whether Ag85 could inhibit autophagy in HL is unknown. Methods: Lymph node samples from patients with HL and healthy controls were collected to assess proliferation and autophagy. The human HL cell line, L-428, was cultured and subjected to Ag85B treatment. Autophagy in L-428 cells was evaluated through western blotting analysis, immunohistochemistry, and transmission electron microscopy. Apoptosis in these cells was measured using flow… More >

  • Open Access

    ARTICLE

    EMP2 promotes hepatocellular carcinoma proliferation and invasion by activating cellular autophagy

    HAIYING PANG1,#, FENGBO WU1,#, YU ZHANG1, NAN ZHANG2, CHUNTING WANG1, QIU LI1, GU HE1,*, PENG ZHANG3,*

    Oncology Research, Vol.33, No.2, pp. 443-464, 2025, DOI:10.32604/or.2024.043948 - 16 January 2025

    Abstract Background: EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family. EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues, where it may play a role in either promoting or inhibiting tumor growth. This study aimed to investigate the expression level, biological functions, and molecular mechanisms of EMP2 in liver cancer. Methods: we analyzed the mRNA expression levels of EMPs family genes in hepatocellular carcinoma (HCC) tissues and normal liver tissues based on the TCGA database and immunohistochemical analysis of tissue microarrays. Subsequently, we constructed HCC cell… More > Graphic Abstract

    EMP2 promotes hepatocellular carcinoma proliferation and invasion by activating cellular autophagy

  • Open Access

    ARTICLE

    Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

    XIANG LI1,#, WENKE JIN2,#, LIFENG WU2, HUAN WANG1, XIN XIE1, WEI HUANG1,*, BO LIU2,*

    Oncology Research, Vol.33, No.1, pp. 67-81, 2025, DOI:10.32604/or.2024.055921 - 20 December 2024

    Abstract Background: Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways. Methods: Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI… More >

  • Open Access

    ARTICLE

    Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

    GENGYUN SUN1,*, YIPING ZHENG1,2, JIANFENG CAI2, JIE GAO2, LIE DONG2, XIANGBIN ZHANG2, YINGHUI HUANG2,*

    Oncology Research, Vol.33, No.1, pp. 171-184, 2025, DOI:10.32604/or.2024.047626 - 20 December 2024

    Abstract Background: Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear. Methods: LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the… More > Graphic Abstract

    Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

  • Open Access

    REVIEW

    Unraveling the molecular crossroads: T2DM and Parkinson’s disease interactions

    TINGTING LIU#, XIANGRUI KONG#, JIANSHE WEI*

    BIOCELL, Vol.48, No.12, pp. 1735-1749, 2024, DOI:10.32604/biocell.2024.056272 - 30 December 2024

    Abstract Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. In recent times, an elevated risk of Parkinson’s disease (PD) development among individuals with T2DM has become evident. However, the molecular mechanisms that underpin the interplay between T2DM and the pathogenesis of PD remain to be elucidated. Nevertheless, recent epidemiological studies have underscored several shared molecular pathways that are crucial for normal cellular function and are also associated with the progression and etiology of both T2DM and PD. This review encapsulates some of the shared pathophysiological mechanisms, including genetic risk factors, More >

  • Open Access

    ARTICLE

    The superiority of PMFs on reversing drug resistance of colon cancer and the effect on aerobic glycolysis-ROS-autophagy signaling axis

    YUQIN YIN1,2,#, YU WU1,#, HONGLIANG HUANG1,2, YINGYING DUAN1,2, ZHONGWEN YUAN1,2, LIHUI CAO1,2, JINJIN YING1,2, YONGHENG ZHOU3,*, SENLING FENG1,2,*

    Oncology Research, Vol.32, No.12, pp. 1891-1902, 2024, DOI:10.32604/or.2024.048778 - 13 November 2024

    Abstract Background: Polymethoxylated flavones (PMFs) are compounds present in citrus peels and other Rutaceae plants, which exhibit diverse biological activities, including robust antitumor and antioxidant effects. However, the mechanism of PMFs in reversing drug resistance to colon cancer remains unknown. In the present study, we aimed to investigate the potential connection between the aerobic glycolysis-ROS-autophagy signaling axis and the reversal of PTX resistance in colon cancer by PMFs. Methods: MTT Cell viability assay and colony formation assay were used to investigate the effect of PMFs combined with PTX in reversing HCT8/T cell resistance ex vivo; the mRNA… More > Graphic Abstract

    The superiority of PMFs on reversing drug resistance of colon cancer and the effect on aerobic glycolysis-ROS-autophagy signaling axis

  • Open Access

    ARTICLE

    MPPa-PDT induced apoptosis and autophagy through JNK and p38 MAPK signaling pathways in A549 cells

    PINGHUA TU, SHANSHAN WANG, KELAN DENG, XINJUN LI, ZHANLING WU*

    BIOCELL, Vol.48, No.11, pp. 1603-1612, 2024, DOI:10.32604/biocell.2024.054364 - 07 November 2024

    Abstract Objectives: The antitumor effects of pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) were observed in several cancers. The objective of this investigation was to examine the antineoplastic efficacy of MPPa-PDT acting on lung carcinoma A549 cells and further elaborate mechanisms. Methods: The viability of A549 cells was examined with cell counting kit-8 after MPPa-PDT disposal. Hoechst 33342 staining, monodansylcadaverine (MDC) staining, and transmission electron microscopy were employed to observe apoptotic bodies and autophagic vesicles. Flow cytometry with Annexin V/propidium iodide (PI) labeling objectively assessed cell death. The expression of associated proteins, including Caspase-3, Beclin-1, LC-3II, and More > Graphic Abstract

    MPPa-PDT induced apoptosis and autophagy through JNK and p38 MAPK signaling pathways in A549 cells

  • Open Access

    RETRACTION

    Retraction: Ailanthone promotes human vestibular schwannoma cell apoptosis and autophagy by downregulation of miR-21

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.11, pp. 1811-1811, 2024, DOI:10.32604/or.2024.056887 - 16 October 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Lovastatin modulation of YAP/TAZ signaling on cardiomyocyte autophagy and mitochondrial damage in myocardial I/R injury

    KAITIAN ZHANG1,#, MINGZHU LI2,#,*, JIANPING ZHANG3, JINFENG LI2, KUNLANG LI2, HUANQIAN LU2, JINYAN LV2

    BIOCELL, Vol.48, No.10, pp. 1489-1501, 2024, DOI:10.32604/biocell.2024.053930 - 02 October 2024

    Abstract Objective: Studies have demonstrated that administering statins promptly following myocardial ischemia/reperfusion (MI/R) can confer cardioprotective benefits. This study investigates whether Lovastatin can modulate the Yes-associated protein/Transcriptional co-activator with PDZ-binding motif (YAP/TAZ) signaling pathway to mitigate cardiomyocyte injury caused by hypoxia/reoxygenation (H/R). Methods: The in vitro MI/R model was established by H/R in rat myocardial H9c2 cells, and the cells were pretreated with varying doses of Lovastatin before reoxygenation. The extent of cellular injury was evaluated by measuring the myocardial enzyme content and cell viability. The levels of oxidative stress and inflammatory factors were quantified by enzyme-linked… More > Graphic Abstract

    Lovastatin modulation of YAP/TAZ signaling on cardiomyocyte autophagy and mitochondrial damage in myocardial I/R injury

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