Jia An^#, Xiang Wang^#, Yajiang Jing, Jianping Huang, Qilong Wang, Gang Zhang, Jing Gao, Liang Peng, Wenli Huang^*, Yonggang Yan^*

Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1405-1420, 2023, DOI:10.32604/phyton.2023.026525

Abstract Although Platycodon grandiflorum (Jacq.) A.DC. is a renowned medicine food homology plant, reports of excessive cadmium (Cd) levels are common, which affects its safety for clinical use and food consumption. To enable its Cd levels to be regulated or reduced, it is necessary to first elucidate the mechanism of Cd uptake and accumulation in the plant, in addition to its detoxification mechanisms. This present study used inductively couple plasma-mass-spectrometry to analyze the subcellular distribution and chemical forms of Cd in different tissues of P. grandiflorum. The experimental results showed that Cd was mainly accumulated in the roots [predominantly in the… More >

Caihui Lan¹, Haifeng Li^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.3, pp. 2985-3010, 2023, DOI:10.32604/cmes.2023.026321

Abstract Sharing of personal health records (PHR) in cloud computing is an essential functionality in the healthcare system. However, how to securely, efficiently and flexibly share PHRs data of the patient in a multi-receiver setting has not been well addressed. For instance, since the trust domain of the cloud server is not identical to the data owner or data user, the semi-trust cloud service provider may intentionally destroy or tamper shared PHRs data of user or only transform partial ciphertext of the shared PHRs or even return wrong computation results to save its storage and computation resource, to pursue maximum economic… More >

Yanju Wang¹, Zhenyu Zhu², Aixue Sha¹, Wenfeng Hao^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.3, pp. 2655-2676, 2023, DOI:10.32604/cmes.2023.025749

Abstract Many titanium alloy subcomponents are subjected to fatigue loading in aerospace engineering, resulting in fatigue failure. The fatigue behavior of Ti₂AlNb alloy subcomponents was investigated based on the Seeger fatigue life theory and the improved Lemaitre damage evolution theory. Firstly, the finite element models of the standard openhole specimen and Y-section subcomponents have been established by ABAQUS. The damage model parameters were determined by fatigue tests, and the reliability of fatigue life simulation results of the Ti₂AlNb alloy standard open-hole specimen was verified. Meanwhile, the fatigue life of Ti₂AlNb alloy Y-section subcomponents was predicted. Under the same initial conditions, the… More >

Sungjin Lee¹, Ahyoung Lee², Min Hong^3,*

Computer Systems Science and Engineering, Vol.46, No.2, pp. 2543-2554, 2023, DOI:10.32604/csse.2023.037055

Abstract Specific medical data has limitations in that there are not many numbers and it is not standardized. to solve these limitations, it is necessary to study how to efficiently process these limited amounts of data. In this paper, deep learning methods for automatically determining cardiovascular diseases are described, and an effective preprocessing method for CT images that can be applied to improve the performance of deep learning was conducted. The cardiac CT images include several parts of the body such as the heart, lungs, spine, and ribs. The preprocessing step proposed in this paper divided CT image data into regions… More >

NADIA Z. SHAABAN¹, NASHWA K. IBRAHIM², HELEN N. SAADA², FATMA H. EL-RASHIDY¹, HEBATALLAH M. SHAABAN³, NERMEEN M. ELBAKARY^2,*, AHMAD S. KODOUS^1,2,*

Oncology Research, Vol.30, No.6, pp. 269-276, 2022, DOI:10.32604/or.2022.027277

Abstract Background: MicroRNAs (miRs) are small (19–25 nucleotides), non-protein coding RNAs that regulate gene expression, and thus play essential roles in cell cycle progression. The evidence has demonstrated that the expression of several miRs is dysregulated in human cancer. Methods: The study includes 179 female patients and 58 healthy women Patients were identified as luminal A, B, Her-2/neu, and basal-like, as well as classified into I, II, and III stages. Analysis of the expression fold change of miR-21 and miR-34a with molecular markers, including the oncogene Bcl-2 (B-cell lymphoma 2) and the tumor suppressor genes BRCA1 (breast cancer susceptibility gene 1),… More >

Libin Wang^1,2,3,#, Xiaohan Li^1,3,#, Jinhai Tian^1,2,3, Jingjing Yu^1,2,3, Qi Huang^1,2,3, Rong Ma^1,2,3, Jia Wang^1,2,3, Jia Cao^1,2,3, Jinping Li^4,*, Xu Zhang^1,2,3,*

Oncologie, Vol.24, No.4, pp. 789-801, 2022, DOI:10.32604/oncologie.2022.026589

Abstract Background: To investigate the characteristics of circular RNA hsa-circ-0006969 in breast cancer and identify it as a novel biomarker for breast cancer. Methods: Three breast cancer (BC) patient tissues were selected to perform human circRNA microarray analysis. GeneSpring 13.0 (Agilent) software was applied for analyzing the data. Another 116 BC patients were recruited for verification. Hsa-circ-0006969 was found as a potential circRNA for BC diagnostic biomarker. The structure of hsa-circ-0006969 was predicted by circPrimer1.2 software. MiRanda v3.3, RNA hybrid 2.1, and Cytoscape 3.6.0 were used for predicting the networks of circRNA-miRNA. T-test, Curve regression, and ROC analysis were applied to… More >

Pooja Dhiman¹, Santosh Kumar Henge¹, Sartaj Singh¹, Avinash Kaur², Parminder Singh^2,3, Mustapha Hadabou^3,*

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3297-3313, 2023, DOI:10.32604/cmc.2023.030558

Abstract This research paper puts emphasis on using cloud computing with Blockchain (BC) to improve the security and privacy in a cloud. The security of data is not guaranteed as there is always a risk of leakage of users’ data. Blockchain can be used in a multi-tenant cloud environment (MTCE) to improve the security of data, as it is a decentralized approach. Data is saved in unaltered form. Also, Blockchain is not owned by a single organization. The encryption process can be done using a Homomorphic encryption (HE) algorithm along with hashing technique, hereby allowing computations on encrypted data without the… More >

Abeer S. Alnahdi^1,*, Mdi B. Jeelani¹, Hanan A. Wahash², Mansour A. Abdulwasaa^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.2, pp. 1315-1343, 2023, DOI:10.32604/cmes.2022.023694

Abstract This study aims to structure and evaluate a new COVID-19 model which predicts vaccination effect in the Kingdom of Saudi Arabia (KSA) under Atangana-Baleanu-Caputo (ABC) fractional derivatives. On the statistical aspect, we analyze the collected statistical data of fully vaccinated people from June 01, 2021, to February 15, 2022. Then we apply the Eviews program to find the best model for predicting the vaccination against this pandemic, based on daily series data from February 16, 2022, to April 15, 2022. The results of data analysis show that the appropriate model is autoregressive integrated moving average ARIMA (1, 1, 2), and… More >

Jiayou Liu, Lian Ding, Xue Zhang, Song Li, Yunxiao Guan, Diwen Jia, Aiping Song, Jiafu Jiang, Fadi Chen^*

Phyton-International Journal of Experimental Botany, Vol.92, No.2, pp. 311-331, 2023, DOI:10.32604/phyton.2022.023896

Abstract Chrysanthemum morifolium, an ornamental crop with diverse forms of inflorescence, is a good model for studying flower development in Asteraceae. However, the genetic background is complex and the mechanisms of regulating flower development are still unclear. Here, we identified two natural mutant lines of chrysanthemum and named them M1 and M2 according to the severity of the phenotype. Both lines showed defects in petal identity, and the petals of the M1 line had a mild phenotype: partially loss of petal identity and conversion of petals into green, leaf-like organs. The M2 line had severe phenotypes: in addition to severe petal… More >

Rui Jiang^1,3,*, Kaisheng Lai², Jianping Xu¹, Xiang Feng¹, Shaoye Wang¹, Xiaojian Wang³, Zhe Liu²

Congenital Heart Disease, Vol.17, No.6, pp. 675-686, 2022, DOI:10.32604/chd.2022.021626

Abstract Background: The etiology of pulmonary arterial hypertension associated with congenital heart disease (PAHCHD) is complicated and the phenotype is heterogeneous. Genetic defects of NOTCH3 were associated with cerebral disease and pulmonary hypertension. However, the relationship between NOTCH3 mutations and the clinical phenotype has not been reported in CHD-PAH. Methods: We eventually enrolled 142 PAH-CHD patients from Fuwai Hospital. Whole exome sequencing (WES) was performed to screen the rare deleterious variants of NOTCH3 gene. Results: This PAH-CHD cohort included 43 (30.3%) men and 99 (69.7%) women with the mean age 29.8 ± 10.9 years old. The pathogenic or likely pathogenic mutations… More >