Guixue Wang^1,*, Li Yang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 10-10, 2019, DOI:10.32604/mcb.2019.08410

Abstract The biomechanics research of Chongqing University (CQU) began in the late 1970s, which has always been guided and helped by Prof. YC Fung. Prof. YP Wu, Prof. GR Wang at CQU were two of the earliest four Chinese scholars to visit and study in Fung's laboratory in the United States. In the autumn of 1979, Fung held a biomechanical workshop in CQU and the former Huazhong Institute of Technology. With the help of him, Prof. YP Wu founded the first Biomechanics Research Lab in China in the late 1970s. The first program for master’s degree… More >

J.D. Humphrey^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 3-4, 2019, DOI:10.32604/mcb.2019.07639

Abstract This article has no abstract. More >

Savio L-Y. Woo^1,*, Peter C-Y Chen²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07631

Abstract This article has no abstract. More >

Shu Chien

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07695

Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, educating many students and their students, and providing his exemplary leadership [1-3]. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the basic principles of biomechanics in living tissues and organs. He opened up new vista for bioengineering, from organs-systems to molecules-genes, and he has provided the foundation of research activities in many institutions in the United States and the world. He has made More >

Zhiyong Li^1,2,*, Dalin Tang^1,3

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 1-7, 2019, DOI:10.32604/mcb.2019.05830

Abstract Cardiovascular disease remains as the leading cause of death worldwide, and the technologies developed by different groups need to be communicated and shared with all related research communities for a boarder implementation. Challenges in imaging technology, mathematical modelling, material description, mechanical representation, disease progression, prediction methods, and final transition to clinical applications are calling for collaborative effort of the entire research community to act together and bring research effort closer to actual clinical applications. Researchers from different disciplines need to reach out to share their expertise, as well as to listen to other people to More >

Yongqiang Li^1,#, Changxin Lai^1,#, Chengchen Zhang², Alexa Singer¹, Suhao Qiu¹, Boming Sun², Michael S. Sacks³, Yuan Feng^1,*

Molecular & Cellular Biomechanics, Vol.16, No.4, pp. 245-251, 2019, DOI:10.32604/mcb.2019.07441

Abstract Surgeries such as implantation of deep brain stimulation devices require accurate placement of devices within the brain. Because placement affects performance, image guidance and robotic assistance techniques have been widely adopted. These methods require accurate prediction of brain deformation during and following implantation. In this study, a magnetic resonance (MR) image-based finite element (FE) model was proposed by using a coupled Eulerian-Lagrangian method. Anatomical accuracy was achieved by mapping image voxels directly to the volumetric mesh space. The potential utility was demonstrated by evaluating the effect of different surgical approaches on the deformation of the… More >

Karol Miller

The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.4, pp. 188-188, 2019, DOI:10.32604/icces.2019.06116

Abstract The field of Biomechanics is in the most exiting state of transition from the theoretical subject of the 20th century to a practical discipline providing patient-specific solutions in the 21st century. Computational biomechanics is becoming instrumental in enabling a new era of personalized medicine based on patient-specific scientific computations. The Finite Element Method is used by almost all members of computational biomechanics community to analyze mathematical models described by sets of partial differential equations. FEM, however, has a number of fairly serious theoretical and practical deficiencies when applied to highly deformable objects of very complicated… More >

Sara Salehyar^{1, †}, Nickolas Forsch^1,†,*, Kathleen Gilbert^2,3, Alistair A. Young^3,4, James C. Perry⁵, Sanjeet Hegde⁵, Jeffrey H. Omens^1,6, Andrew D. McCulloch^1,6

Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 179-183, 2019, DOI:10.32604/mcb.2019.07384

Abstract Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. Infants diagnosed with TOF require surgical interventions to survive into adulthood. However, as a result of postoperative structural malformations and long-term ventricular remodeling, further interventions are often required later in life. To help identify those at risk of disease progression, serial cardiac magnetic resonance (CMR) imaging is used to monitor these patients. However, most of the detailed information on cardiac shape and biomechanics contained in these large four-dimensional (4D) data sets goes unused in clinical practice for lack of efficient and… More >

Petit Claudie¹, Guignandon Alain², Avril Stéphane^1,*

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 87-108, 2019, DOI:10.32604/mcb.2019.06415

Abstract The contractile behavior of smooth muscle cells (SMCs) in the aorta is an important determinant of growth, remodeling, and homeostasis. However, quantitative values of SMC basal tone have never been characterized precisely on individual SMCs. Therefore, to address this lack, we developed an in vitro technique based on Traction Force Microscopy (TFM). Aortic SMCs from a human lineage at low passages (4-7) were cultured 2 days in conditions promoting the development of their contractile apparatus and seeded on hydrogels of varying elastic modulus (1, 4, 12 and 25 kPa) with embedded fluorescent microspheres. After complete… More >

Mingzhi Luo¹, Kai Ni¹, Peili Yu¹, Yang Jin², Lei Liu¹, Jingjing Li¹, Yan Pan¹, Linhong Deng^1,*

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 141-151, 2019, DOI:10.32604/mcb.2019.06756

Abstract Airway hyperresponsiveness (AHR) is the cardinal character of asthma, which involves the biomechanical properties such as cell stiffness and traction force of airway smooth muscle cells (ASMCs). Therefore, these biomechanical properties comprise logical targets of therapy. β2-adrenergic agonist is currently the mainstream drug to target ASMCs in clinical practice for treating asthma. However, this drug is known for side effects such as desensitization and non-responsiveness in some patients. Therefore, it is desirable to search for new drug agents to be alternative of β2-adrenergic agonist. In this context, sanguinarine, a natural product derived from plants such… More >