Bin Yang^1,2,3,*, Hao Sun¹, Aiyuan Wang¹, Qun Wang²

Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 49-62, 2020, DOI:10.32604/mcb.2019.07534

Abstract In order to predict and evaluate injury mechanism and biomechanical response of the facial impact on head injury in a crash accident. With the combined modern medical imaging technologies, namely computed tomography (CT) and magnetic resonance imaging (MRI), both geometric and finite element (FE) models for human head-neck with detailed cranio-facial structure were developed. The cadaveric head impact tests were conducted to validate the headneck finite element model. The intracranial pressure, skull dynamic response and skull-brain relative displacement of the whole head-neck model were compared with experimental data. Nine typical cases of facial traffic accidents More >

Chien-Chi Liu¹, Sai-Wei Yang^1,*, Tsui-Fen Yang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 120-122, 2019, DOI:10.32604/mcb.2019.07150

Abstract Scoliosis is the most common type of spinal deformity of the young adults, and women outnumber men about 10:1 [1], in which the Adolescent Idiopathic Scoliosis (AIS) is up to 90% for ages 10 to 16year-old teenagers [2]. Studies revealed that due to the 3-dimensional musculoskeletal deformities, the AIS subjects to the dynamic postural instability including vestibular and proprioception disorders [3-5]. Dynamic postural Balance is monitored by integration of cortical modulation and somatosensory response [6], and the either motor or sensory impairment lead to balance dysfunction as well as pathologic gait. Studies revealed that the… More >

Yao Guo¹, Yijiang Song², Yu Zhang¹, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 119-119, 2019, DOI:10.32604/mcb.2019.07134

Abstract Osteoarthritis (OA), with its high disability and mortality rate, is the most common arthritis throughout the world [1]. Exposure of articular cartilage to excessive mechanical stress is deeply involved in the pathogenesis of osteoarthritis (OA) [2,3]. However, the mechanism of how mechanical stress causes cartilage degradation is not clear yet. Here we report that bioinformatics-based integrative analyses can assist in the study of mechanisms modulated by mechanical stress within OA pathology, and we reveal that B-cell Translocation Gene 2 (BTG2) can be a mechanosensitive gene involved in OA development. We obtained OA-associated differentially expressed genes… More >

Xiaofei Wang^1,2,*, Yubo Fan^1,2

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 112-112, 2019, DOI:10.32604/mcb.2019.07053

Abstract Accommodation is the ability of the eye to adjust its lens thickness to alter the refractive power through the contraction of ciliary muscles. The loss of accommodation ability due to aging leads to presbyopia, a condition in which the eye is unable to focus on near objects. Glaucoma is a disease that vision is impaired due to damage of the retinal ganglion cell at the optic nerve head (ONH) region, which is the leading cause of irreversible blindness worldwide. The biomechanical theory of glaucoma suggests that the deformations of ONH tissues could (directly or indirectly)… More >

Yongqiang Li^1,#, Changxin Lai^1,#, Chengchen Zhang², Alexa Singer¹, Suhao Qiu¹, Boming Sun², Michael S. Sacks³, Yuan Feng^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 111-111, 2019, DOI:10.32604/mcb.2019.07098

Abstract Surgeries such as implantation of deep brain stimulation devices require accurate placement of devices within the brain. Because placement affects performance, image guidance and robotic assistance techniques have been widely adopted. These methods require accurate prediction of brain deformation during and following implantation. In this study, a magnetic resonance (MR) image-based finite element (FE) model was proposed by using a coupled Eulerian-Lagrangian method. Anatomical accuracy was achieved by mapping image voxels directly to the volumetric mesh space. The potential utility was demonstrated by evaluating the effect of different surgical approaches on the deformation of the… More >

Ning Jiang^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 102-102, 2019, DOI:10.32604/mcb.2019.07486

Abstract Force is not only involved in motion, but also involved in molecular interactions that guide cells to execute important physiological functions. Getting to know Dr. Fung at an early age shaped my college major decision, which lead me into the field of biomedical engineering. Applying a force-based measurement tool to study T cell receptor interaction with ligands in graduate school prepared me to use technology development as a foundation to answer important biological and clinical questions.
By combining engineering principle, quantitative modeling, and a deep understanding of biology and medicine, my current research focuses in… More >

Taiji Adachi^1,*, Yoshitaka Kameo¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 88-88, 2019, DOI:10.32604/mcb.2019.07417

Abstract Bone adaptation by remodeling is a process to change its outer shape and internal structure to the changing mechanical environment by osteoclastic bone resorption and osteoblastic bone formation. These cellular activities are regulated by mechanosensory network of osteocytes embedded in bone matrix. An imbalance between bone resorption and formation due to low loadings or disuse results in metabolic bone disorders such as osteoporosis. Many studies have identified various signaling pathways that regulate these cellular activities; however, the physiological and pathological conditions of bone as a system remain difficult to understand because of the complexity of… More >

Wei Sun^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 64-64, 2019, DOI:10.32604/mcb.2019.08533

Abstract Fluid–structure interaction (FSI) is a common phenomenon in biological systems. FSI problems of practical interest, such as fish/mammalian swimming, insect/bird flight, and human cardiac blood flow and respiration often involve multiple 3D immersed bodies with complex geometries undergoing very large structural displacements, and inducing very complex flow phenomena. Simulation of heart valve FSI is a technically challenging problem due to the large deformation of the valve leaflets through the cardiac fluid domain in the atrium and ventricular chambers.
Recently, we developed a FSI computational framework [1] for modeling patient-specific left heart (LH) dynamics using smoothed… More >

Yue Mei^1,2,3, Stephane Avril^3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 44-44, 2019, DOI:10.32604/mcb.2019.07034

Abstract Characterizing regional variations of material properties in soft tissues is essential for biomedical engineering and clinical medicine, including but not limited to cancerous disease detection and patient-specific surgical planning of cardiovascular diseases. Identification of nonhomogeneous material property distribution usually requires solving inverse problems in nonlinear elasticity. Generally, inverse algorithms can be categorized into two groups: iterative inversion and direct inversion. In direct inversion, the material property distribution of soft tissues is estimated directly from the equilibrium equations, while the inverse problem is posed as an optimization problem in iterative inversion. In this presentation, we compare… More >

Liang Wang¹, Haibo Jia², Luping He², Rui Lv¹, Xiaoya Guo³, Chun Yang^4,5, Don P. Giddens^6,7, Habib Samady⁶, Akiko Maehara⁸, Gary S. Mintz⁸, Dalin Tang^1,*,5

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 23-24, 2019, DOI:10.32604/mcb.2019.07522

Abstract Plaque erosion, one of the primary causes for coronary thrombosis, is responsible for about one third of the patients with acute coronary syndrome (ACS) [1]. Histological studies characterized the eroded plaque as a plaque with following morphological features: 1) plaque intima having direct contact with intraluminal thrombus due to the absence of endothelium or endothelial injury; 2) without rupture in the fibrous cap; 3) abundance of proteoglycans and smooth muscle cells on the luminal surface under the thrombus [2]. These characteristics has been applied in in vivo diagnosis of plaque erosion using optical coherence tomography… More >