Małgorzata Wyciszkiewicz, Agnieszka Saeid^*, Katarzyna Chojnacka

Journal of Renewable Materials, Vol.5, Suppl.1, pp. 39-52, 2017, DOI:10.7569/JRM.2017.634132

Abstract The aim of this work was to evaluate the effects of using B. megaterium in solubilization of phosphates from different secondary raw materials, such as fish bones, poultry bones, ashes and phosphorite, by identification of the effect of different doses of phosphorus-bearing materials on the growth of microbial cells and the effectiveness of the solubilization process. Both FTIR as well as SEM-EDX techniques were used to compare the effect of the acids on renewable phosphorus source. Two doses of mentioned materials were used: 2 and 30 g/L. The effect of solubilization was expressed as the solubilization More >

Arun Kumar Pradhan^1,2*, Prafulla Kumar Sahoo¹, Pradeep Kumar Rana²

Journal of Renewable Materials, Vol.5, No.5, pp. 371-379, 2017, DOI:10.7569/JRM.2017.634129

Abstract Chitosan grafted with poly(methyl-methacrylate) (PMMA) and adsorbed with kaolin functionalized as bioadhesive was prepared via emulsion polymerization technique and physiochemically characterized as a bone-graft substitute. The so prepared grafted bioactive bone cement (BBC) bionanocomposites (BNCs), chitosan-g-PMMA/kaolin, was characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, field-emission scanning electron microscopy (FESEM) and thermogravimetric analysis (TGA). The water uptake, retention ability and the nanosize particle arrangement in the polymeric BBC-BNCs were studied along with the mechanical and biodegradation properties. These preliminary investigations of the BNCs will open the door for their use in bioadhesive More >

Agnieszka Sobczak-Kupiec¹, Klaudia Pluta¹, Dagmara Malina^1*, Bożena Tyliszczak²

Journal of Renewable Materials, Vol.5, No.3-4, pp. 180-188, 2017, DOI:10.7569/JRM.2017.634106

Abstract In recent years, the development of composite biomaterials has been the subject of very intensive research. The elaboration of technology for manufacturing new biomaterials will allow their practical implementation and adaptation to changing market needs. One of the key components in the developed composite materials will be natural origin hydroxyapatite (HAp) and tricalcium phosphate (TCP) obtained from bone products. In this study, preparation and detailed characterization of bone-derived calcium phosphates as a component of biomaterial composites is proposed. This novel method of obtaining hydroxyapatite for biomedical applications allows the obtainment of a material with expected More >

Longjia Li^1,2, Tianbao Qian^2,3, Fei Hang^{1, 2, *}

Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 221-234, 2017, DOI:10.3970/mcb.2017.014.221

Abstract Bone is an important natural hierarchical biomaterial which supports human body and protect organs. Its mechanical property has been researched extensively. In this experimental work, 3D microscope and scanning electron microscope (SEM) were used to research crack expansion on bovine femur cortical bone transverse section. Softwares such as image J and Photoshop were used in image and data analyses. Our results suggested that the interface energy of extending through osteons is smaller than the interface energy of extending along cement lines. Cracks are more likely to extend through osteons. Further investigations are needed to reduce More >

Ruikai Chen¹, Delphine Dean^1,*

Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 153-169, 2017, DOI:10.3970/mcb.2017.014.153

Abstract Vascular smooth muscle cells (VSMCs) play an important role in regulating blood flow and pressure by contracting and relaxing in response to a variety of mechanical stimuli. A fully differentiated and functional VSMC should have both the ability to contract and relax in response to environmental stimuli. In addition, it should have the proper mechanical properties to sustain the mechanically active vascular environment. Stem cells can differentiate towards VSMC lineages and so could be used as a potential treatment for vascular repair. However, few studies have assessed the time it takes for stems cells to… More >

Pranav S. Sapkal^1,*, Abhaykumar M. Kuthe¹, Shantanu Mathankar², Akash A. Deshmukh

Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 125-136, 2017, DOI:10.3970/mcb.2017.014.123

Abstract β-TCP-Zirconia scaffolds with different architectures were fabricated by means of 3D-Bioplotting in order to enhance the mechanical and in-vitro ability of the scaffold to heal large size bone defects. In the present study scaffold architecture with different strand orientations (0°-90°, 0°-45°-135°-180°, 0°-108°-216° and 0°-72°-144°-36°-108°) were fabricated, characterized and evaluated for mechanical strength and cell proliferation ability. β-TCP powder (25 µm) and PVA (Polyvinyl Alcohol) was acquired from Fisher Scientific, India. Zirconia (18 to 32 µm) was procured from Lobachemie, India. In brief 7.5%, PVA in distilled water was used as a binder and was mixed… More >

Tu D. Dan¹, Laura Doyle¹, Amar J. Raval², Andrew Pridjian², Leonard G. Gomella², Robert B. Den¹

Canadian Journal of Urology, Vol.23, No.3, pp. 8301-8305, 2016

Abstract Radium-223 dichloride is a first-in-class bone-directed radiopharmaceutical that has been shown to prolong survival in men with metastatic castrate resistant prostate cancer (mCRPC). Unlike other radiopharmaceuticals, radium-223 uniquely uses alpha-emission to deliver high intensity, short range cytoxic treatments resulting in minimal myelosuppression. Following the results of the ALSYMPCA trial, radium-223 (Xofigo) was FDA approved in the United States in May 2013 and approved by Health Canada in December 2013 for the treatment of mCRPC with symptomatic bone metastases and no visceral disease. This “How I do it” article describes the background of radium 223 as More >

Rajasree Pia Chowdry¹, Elisa Ledet², Lahiru Ranasinghe³, Alton Oliver Sartor²

Canadian Journal of Urology, Vol.23, No.5, pp. 8483-8486, 2016

Abstract The mixed-lineage leukemia (MLL) protein acts as a histone methyltransferase regulating multiple genetic elements. Rearrangements of the MLL gene result in expression of MLL-fusion proteins that occur in some acute leukemias and are associated with poor prognosis. The MLL protein complex has been shown to interact with the androgen receptor via the MLL-menin subunit, thus promoting gene activation. The presence of MLL translocation has not been previously reported in patients with castrate resistant prostate cancer (CRPC). We describe two cases of metastatic CRPC with a translocation in the MLL gene detected by a specific fluorescent More >

Joan S. Ko, Angela D. Gupta, Heather N. Di Carlo, Kathy Lue, John P. Gearhart

Canadian Journal of Urology, Vol.23, No.5, pp. 8476-8479, 2016

Abstract Bladder exstrophy and cloacal exstrophy are rare congenital defects of the genitourinary tract that require complex surgical reconstruction. Malrotation of the bony pelvis causes a characteristic diastasis of the pubic symphysis, which is surgically reduced at the time of initial bladder closure. For a successful primary closure without tension such that the bladder can be placed deep within the pelvis, pelvic osteotomy is often used. However, alternative techniques have been utilized to bring the pubic rami into apposition. The authors present four bladder/ cloacal exstrophy patients in which an intrapubic wire was used for pubic More >

M. L. Lambri^1,2, E. D. Giordano^2,3, P. B. Bozzano⁴, F. G. Bonifacich², J. I. Pérez-Landazábal^5,6, G. I. Zelada², D. Gargicevich², V. Recarte^5,6, O. A. Lambri^2*

Journal of Renewable Materials, Vol.4, No.4, pp. 251-257, 2016, DOI:10.7569/JRM.2016.634111

Abstract The denaturation processes of collagen in the temperature range between 450 K and 670 K are revealed through studies performed on cow rib bones by means of mechanical spectroscopy, differential scanning calorimetry, thermogravimetry, scanning electron microscopy and infrared spectroscopy. The conformational change of the collagen molecules from a triple helix structure to a random coil was found at around 510 K. It was determined that the transformation is developed through the viscous movement of fibrils with an activation energy of (127 ± 8) kJ/mol. The second stage of massive bulk deterioration of the collagen was More >