Ulf W. Tunn¹, Amulf Stenzl², Wolfgang Schultze-Seemann³, Arne Strauss⁴, Manfred Kindler⁵, Kurt Miller⁶, Manfred P. Wirth⁷, Niko Zantl⁸, Matthias Schulze⁹, Christoph May¹⁰, Amelie Ruebel¹⁰, Katrin Birkholz¹⁰, Viktor Gruenwald¹¹

Canadian Journal of Urology, Vol.19, No.3, pp. 6261-6267, 2012

Abstract Introduction: Approximately 30% of patients with renal cell cancer (RCC) develop bone metastasis, causing skeletal-related events (SREs): pathologic fracture, spinal cord compression, surgery to bone, and radiotherapy. Zoledronic acid demonstrated significant clinical benefit in RCC patients in a retrospective analysis. The primary objective of this prospective study was to evaluate the proportion of patients experiencing ≥ 1 SRE during 12 months of zoledronic acid treatment and to verify the retrospective data.
Materials and methods: Fifty patients with histologically confirmed RCC and evidence of ≥ 1 cancer-related bone lesion, and ≤ 3 prior bisphosphonate applications were enrolled across… More >

MC. Ho Ba Tho¹, PE Mazeran², K El Kirat¹, S.F. Bensamoun¹

CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.6, pp. 557-578, 2012, DOI:10.3970/cmes.2012.087.557

Abstract Mechanical properties of cortical human bone have been investigated for more than four decades. Numerous experimental investigations on bone characterization were performed ; mechanical, vibrational, acoustical testing and morphological, physico-chemical investigations. Due to the techniques, different levels of investigation were performed and subsequently quantitative parameters are concerning different level of structure of bone (organ, tissue,... ). According to our knowledge, few investigations were performed simultaneously on mechanical, morphological and physico-chemical properties of bone. The objectives of the present study were to investigate the influence of multiscale structural characteristics of the bone tissue on its mechanical More >

R. Khanna^1,2, D. R. Katti¹, K. S. Katti¹

CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.6, pp. 530-556, 2012, DOI:10.3970/cmes.2012.087.530

Abstract Here we report a new in situ nanoindentation technique developed to evaluate the composite mechanical behavior of cell-biomaterial construct under physiological conditions over the time scale of bone nodule generation. Using this technique, mechanical behavior of osteoblast cell-substrate interfaces on tissue engineered materials (chitosan-polygalacturonic acid-nanohydroxyapatite (CPH) films) is investigated. Mechanical behavior of cells in the elastic regime over the time scale of cell adhesion (1 day), proliferation (4 days), development (8 days) and maturation (22 days) of bone nodules is evaluated. Our results indicate that the elastic properties of flat cells are higher (indicating stiffer… More >

V. Sansalone^1,∗, V. Bousson², S. Naili¹, C. Bergot², F. Peyrin³, J.D. Laredo², G. Haïat¹

CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.5, pp. 387-410, 2012, DOI:10.3970/cmes.2012.087.387

Abstract This paper investigates the effects of the heterogeneous distribution of the Haversian Porosity (HP) and Tissue Mineral Density (TMD) on the elastic coefficients of bone in the human femoral neck. A bone specimen from the inferior femoral neck was obtained from a patient undergoing standard hemiarthroplasty. The specimen was imaged using 3-D synchrotron micro-computed tomography (voxel size of 10.13 mm), leading to the determination of the anatomical distributions of HP and TMD. These experimental data were used to estimate the elastic coefficients of the bone using a three-step homogenization model based on continuum micromechanics: (i)… More >

Bo Huo, Man Hu, Ping Li

The International Conference on Computational & Experimental Engineering and Sciences, Vol.18, No.4, pp. 103-104, 2011, DOI:10.3970/icces.2011.018.103

Abstract It has been widely accepted that movement of human body causes the fluid flow through pores or channels inside bone and subsequently on osteoblasts on the surface of trabeculae and osteocytes inside lacunae. The mechanism of calcium response in a bone cell and calcium transfer between bone cells is critical in understanding the communication between bone cells and calcium deposition on bone matrix. Our previous works have demonstrated that when micropatterned osteoblastic cell network with gap junctions was exposed to fluid flow, extracellular ATP diffusion following the activation of calcium response in neighboring cells plays… More >

Y. Zhao, K.S. Yeo, P. Yu, S.J. Ang

The International Conference on Computational & Experimental Engineering and Sciences, Vol.16, No.2, pp. 59-60, 2011, DOI:10.3970/icces.2011.016.059

Abstract This paper presents the application of an Arbitrary Lagrangian Eulerian (ALE) and Singular Value Decomposition (SVD) based Generalized Finite Difference (GFD) method to simulate the C- and S-starts of a carangiform-type fish. The numerical model incorporate fluid-structure interaction (FSI) and computation is carried out on a hybrid grid comprising meshfree nodes around the undulating/deforming swimming fish and Cartesian nodes in the background. The meshfree nodes convect with the deformation and motion of the swimmer. A curvature-wave model of the backbone is used to generate the C- and S-start actions of the fish from the experimental More >

Ligia Munteanu¹, Veturia Chiroiu¹, Valeria Mosnegutu¹

CMC-Computers, Materials & Continua, Vol.26, No.2, pp. 137-156, 2011, DOI:10.3970/cmc.2011.026.137

Abstract In this paper, yet another method for evaluating the elastic modulus for human bones is introduced and investigated. This method adopts the Jankowski and Tsakalakos strain energy function in which, the Born-Mayer energy term is the predominant term for calculations the elastic constants. By taking accounts the directional aspects of the spatial structure of bones, we obtain different values for the Young's modulus depending on the direction of the applied force with respect to the material's structure. The inverse problem analyzed in this paper is solved by inversion of the experimental data. An efficient stopping More >

I. Pérez¹, R. Roselló¹, C. Recarey¹, M. Cerrolaza²

CMES-Computer Modeling in Engineering & Sciences, Vol.79, No.3&4, pp. 183-200, 2011, DOI:10.3970/cmes.2011.079.183

Abstract Modeling the geometry and behavior of human bones is of the most concern when dealing with bone remodelling (external and internal) and poroelastic analysis. Complex geometries are frequently found in the human skeleton as well as orthotropic behavior of bone tissue. Spongy bone has a completely different constitution as compared with compact bone, which adds another relevant consideration if we want to get reliable results in biomechanical analysis. The modeling of both compact and spongy human-bone tissue is carried out by using packaging-particle methods. The methods generate circles (2D domains) and spheres (3D domains) in More >

M.A. Argenta¹, A.P. Gebert², E.S. Filho³, B.A. Felizari⁴, M.B. Hecke⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.79, No.3&4, pp. 159-182, 2011, DOI:10.3970/cmes.2011.079.159

Abstract Various methods in the literature proposesequations to calculate the stiffness as a function of density of bone tissue such as apparent density and ash density among others[Helgason, Perilli, Schileo, Taddei, Brynjolfsson and Viceconti, 2008]. Other ones present a value of an equivalent elasticity modulus, obtained by statistical adjustments of curves generated through mechanical compression tests over various specimens[Chevalier, Pahr, Allmer, Charlebois and Zysset, 2007; Cuppone, Seedhom, Berry and Ostell, 2004]. Bone tissue is a material withdifferent behaviors according to the scale of observation. It has a complex composite hierarchical structure, which is responsible for assign More >

Richard Casey¹, Zsuzsanna Gesztesi¹, Joseph Rochford²

Canadian Journal of Urology, Vol.17, No.3, pp. 5170-5177, 2010

Abstract Objectives: To evaluate the effect of zoledronic acid on androgen deprivation therapy in patients with hormone-sensitive prostate cancer by measuring the percentage change in lumbar-spine bone mineral density (BMD) at 12 and 24 months.
Materials and methods: An open-label, multicenter, randomized, two-phase study was conducted in patients with hormone-sensitive prostate cancer (N = 200) receiving 10.8 mg goserelin acetate with or without zoledronic acid (4 mg intravenously) every 3 months. In phase I, patients were randomized to goserelin acetate alone or goserelin acetate plus zoledronic acid for 12 months. In phase II, patients receiving goserelin acetate plus… More >