Xinliang Fu^1,#, Wen Du^1,#, Tao Li², Yifei Shen¹, Ngai-Fung Ruan¹, Huiling Ling¹, Xingbo Wu¹, Ziqi Qin¹, Xiting Zhu¹, Xueqi Gan^1,*

BIOCELL, Vol.50, No.7, 2026, DOI:10.32604/biocell.2026.077349 - 29 June 2026

Abstract Objectives: Mitochondrial function is intricately linked to osteogenic and osteoclastic differentiation. The mitochondrial calcium uniporter (MCU) is a critical regulator of mitochondrial function, influencing key aspects of cellular metabolism and signaling. However, the precise mechanisms by which MCU modulates osteogenic activity remain unclear. This study aimed to elucidate the impact of MCU-mediated regulation of mitochondrial function on bone remodeling and to explore the underlying mechanisms. Methods: The mouse pre-osteoblastic cells (MC3T3-E1) were treated with the MCU-specific inhibitor Ru265 during osteogenic induction to assess changes in osteogenic differentiation capacity, mitochondrial function, and mitochondrial dynamics. Additionally, MCU global… More >

Lindokuhle M. Ngema¹, Samson A. Adeyemi^1,2,*, Yahya E. Choonara^1,3,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.077723 - 16 June 2026

Abstract Primary bone cancer is a relatively rare malignant tumor that manifests in the bone and affects the normal functioning of the bone tissue. Primary bone cancer can be characterized into three subtypes, which are osteosarcoma, chondrosarcoma, and Ewing sarcoma. Notably, the treatment of primary bone cancer with conventional modalities, like chemotherapy and surgical interventions, has been overwhelmed with dismal clinical outcomes. The conventional therapies are challenged with non-specificity, resulting in off-target effects and ultimate harm to healthy tissue. Particularly, chemotherapy as a first-line treatment option is riddled with poor drug bioavailability, limited tumor accumulation, and More >

Dalin Wang¹, Mingcai Zhang¹, Richard Hastings², Patrick George¹, Ryan Ranzau¹, Jinxi Wang^1,3,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.074572 - 21 April 2026

Abstract Objective: Although endplate (EP) injury may cause intervertebral disc (IVD) degeneration and Modic changes (MCs) in the vertebral bone marrow (VBM), EP injury-induced synchronous cellular reactions and their crosstalk in the IVD and VBM remain unclear. This protocol-based study aimed to streamline and optimize the methods of tissue harvest and cell preparation for flow cytometry (FCM) analysis of T-cell and macrophage subpopulations in both VBM and IVD adjacent to the surgically induced EP microfracture in mice. Methods: EP injury or sham procedure was performed at the spinal levels L4-5 and L5-6 in male mice. Step-by-step… More >

Jiawen Chen^1,#, Zelin Liu^1,#, Keke Huang¹, Jinlan Li¹, Yajie Zhang¹, Dandan Chen¹, Yanjie Ruan², Ying Pan¹, Furun An¹, Yang Wan^1,*, Jiyu Wang^1,3,*, Qianshan Tao^1,*

European Cytokine Network, Vol.37, No.1, pp. 25-39, 2026, DOI:10.32604/ecn.2026.077875 - 13 April 2026

Abstract Objectives: B-cell lymphoma exhibits significant clinical heterogeneity, necessitating improved biomarkers for risk stratification. C-C chemokine receptor 7 (CCR7) and trimethylation of histone H3 lysine 9 (H3K9me3) are implicated in cellular senescence and tumor invasion. While the clinical significance of their co-expression in lymphomagenesis remains unclear. This study aims to define the expression profiles of CCR7 and H3K9me3 in B-cell lymphoma, explore their correlation with aggressive clinical indicators, and evaluate their combined prognostic value. Methods: The expression of CCR7 and H3K9me3 in tumor tissues from B-cell lymphoma patients was analyzed by immunohistochemical (IHC) double-staining. The mechanistic… More >

Sang-Hyun Lee^*, Qingtao Meng

CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.077207 - 09 April 2026

Abstract Accurate and timely detection of rice leaf diseases is critical for ensuring global food security and maximizing agricultural yields. However, existing deep learning methods often struggle to balance the high accuracy required for detecting multi-scale lesions in complex field environments with the computational efficiency necessary for edge device deployment. This paper proposes You Only Look Once for Lightweight Detection (YOLOv11-LD), a lightweight object detection model for multi-scale rice leaf disease detection in real paddy field environments. The model is built on YOLOv11n and integrates a Re-parameterized Vision Transformer (RepViT) backbone, a Bidirectional Feature Pyramid Network… More >

Cristiane Michele Alves de Oliveira¹, Bruna Carolina Dorm¹, Antonio José Felix Carvalho², Deliane da Silva Cabral², Flávia Aparecida Resende Nogueira¹, Nádia Andrade Aleixo¹, Mônica Rosas Costa Iemma¹, Eliane Trovatti^1,*

Journal of Renewable Materials, Vol.14, No.3, 2026, DOI:10.32604/jrm.2025.02025-0166 - 25 March 2026

Abstract Materials from natural sources have been studied to replace the conventional synthetic or animal-derived products as a safer alternative to be used in the healthcare field. In dentistry, guided bone regeneration (GBR) relies on barrier membranes, predominantly from animals or synthetic materials, to improve osteogenesis by avoiding undesired soft tissue cells from defect sites. In this study, membranes were prepared from zein, a corn-derived protein, using a simple extraction and casting method, followed by optional formaldehyde cross-linking to evaluate their behavior for application in GBR. The membranes were characterised by FTIR, DSC, TGA, tensile strength… More > Graphic Abstract

Francisco Raúl Borzone^1,2,*, María Belén Giorello¹, Agustina Freire³, Leandro Marcelo Martinez⁴, Leonardo Feldman⁵, Federico Dimase⁶, Pablo Evelson³, Irene Larripa⁷, Emilio Batagelj⁸, Marcela Beatriz González Cid⁹, Norma Alejandra Chasseing^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074321 - 23 March 2026

Abstract Backgrounds: Breast cancer metastasis remains the leading cause of mortality and frequently targets the bone. Breast cancer cells release soluble factors and extracellular vesicles that disrupt bone marrow (BM)/bone homeostasis, promoting osteoclastogenesis and the accumulation of senescent cells. In line with updated cancer hallmarks, senescent mesenchymal stem/ stromal cells (MSCs), osteoblasts, and osteocytes contribute to remodeling of the BM microenvironment, thereby favoring pre-metastatic niche (PMN) formation and subsequent bone metastasis. We previously demonstrated that untreated stage III-B breast cancer patients (BCPs) exhibit increased oxidative stress and elevated reactive oxygen species (ROS) levels, accompanied by senescent… More > Graphic Abstract

Dina S. M. Hassan^*, Reem Ibrahim Alkanhel, Thuraya Alrumaih, Shiyam Alalmaei

CMC-Computers, Materials & Continua, Vol.87, No.2, 2026, DOI:10.32604/cmc.2026.074751 - 12 March 2026

Abstract The sustainability of the Internet of Things (IoT) involves various issues, such as poor connectivity, scalability problems, interoperability issues, and energy inefficiency. Although the Sixth Generation of mobile networks (6G) allows for Ultra-Reliable Low-Latency Communication (URLLC), enhanced Mobile Broadband (eMBB), and massive Machine-Type Communications (mMTC) services, it faces deployment challenges such as the short range of sub-THz and THz frequency bands, low capability to penetrate obstacles, and very high path loss. This paper presents a network architecture to enhance the connectivity of wireless IoT mesh networks that employ both 6G and Wi-Fi technologies. In this… More >

Fitra Yurid^1,2, Nadiatus Silmi³, Heni Rachmawati^4,5, Nanda Nagara², Riyanti Ekafitri⁶, Athanasia Amanda Septevani^2,7,*

Journal of Renewable Materials, Vol.14, No.2, 2026, DOI:10.32604/jrm.2025.02025-0118 - 25 February 2026

Abstract This study investigates the potential of starch extracted from underutilized agro-industrial resources as non-food-competing raw materials for the development of flexible bioplastics for food packaging applications. Starch was extracted from three biomass sources: rubber cassava (Manihot glaziovii), banana stem, and banana peel from Ambonese banana (Musa acuminata L.). Rubber cassava starch (S_RC) exhibited the highest starch yield (50.68 ± 0.28%), significantly surpassing banana stem (S_BS, 14.20 ± 0.25%) and banana peel (S_BP, 3.07 ± 0.15%). The amylose contents of S_RC, S_BS, and S_BP were 28.18%, 52.80%, and 56.57%, respectively, while their amylopectin contents were 71.83%, 47.20%, and 43.43%. FTIR spectra… More > Graphic Abstract

Frank Traub^1,#, Muhammad A. Panezai^1,#, Michaela Moisch¹, Julia Melke¹, Leonard Schöbel¹, Tilmann Busse¹, Fei Xing², Jiachen Sun², Ulrike Ritz^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.071919 - 24 February 2026

Abstract Objectives: Photodynamic therapy (PDT) is a minimally invasive method used in the treatment of various cancers and skin diseases, but it is not widely used in bone cancer, where the current therapy is often not effective and accompanied by side effects. Alternative and more effective therapies like PDT are needed. In this in-vitro study, the effect of the photosensitizer (PS) chlorin e6 (Ce6) on cancerous bone tumor cells using PDT was examined. Methods: A total of 27 tissue specimens from patients with primary bone cancers or bone metastases of different origins were genetically characterized and treated… More >