Mesfer Al Duhayyim^1,*, Areej A. Malibari², Marwa Obayya³, Mohamed K. Nour⁴, Ahmed S. Salama⁵, Mohamed I. Eldesouki⁶, Abu Sarwar Zamani⁷, Mohammed Rizwanullah⁷

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5473-5489, 2022, DOI:10.32604/cmc.2022.031976

Abstract The skeletal bone age assessment (BAA) was extremely implemented in development prediction and auxiliary analysis of medicinal issues. X-ray images of hands were detected from the estimation of bone age, whereas the ossification centers of epiphysis and carpal bones are important regions. The typical skeletal BAA approaches remove these regions for predicting the bone age, however, few of them attain suitable efficacy or accuracy. Automatic BAA techniques with deep learning (DL) methods are reached the leading efficiency on manual and typical approaches. Therefore, this study introduces an intellectual skeletal bone age assessment and classification with the use of metaheuristic with… More >

Soliman Abdalla^1,2,*, Shiref Kandil²

Journal of Renewable Materials, Vol.10, No.11, pp. 2699-2716, 2022, DOI:10.32604/jrm.2022.022334

Abstract In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get better products. The present study… More >

Xinshan Cao^*, Ling Xu^†, Quanyuan Liu^*, Lijuan Yang^‡, Na Li^§, Xiaoxiao Li^*

Oncology Research, Vol.27, No.3, pp. 301-309, 2019, DOI:10.3727/096504018X15213058045841

Abstract Our study aimed to investigate the roles and possible regulatory mechanism of miR-1277 in the development of hepatocellular carcinoma (HCC). HCC patients were identified from patients who were diagnosed with focal liver lesions using magnetic resonance imaging (MRI). The expression levels of miR-1277 in the serum of HCC patients and HepG2 cells were measured. Then miR-1277 mimic, miR-1277 inhibitor, or scramble RNA was transfected into HepG2 cells. The effects of miR-1277 overexpression and suppression on HepG2 cell proliferation, migration, and invasion were then investigated. Additionally, the expression levels of epithelial– mesenchymal transition (EMT)-related markers, including E-cadherin, -catenin, and vimentin, were… More >

FABIANO BINI^1,*, ANDRADA PICA¹, ANDREA MARINOZZI², FRANCO MARINOZZI¹

BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150

Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization at nanoscale and on the… More >

RéMY GAUTHIER^1,*, HéLèNE FOLLET², ANA-MARIA TRUNFIO-SFARGHIU³, DELPHINE FARLAY², NINA ATTIK^4,5, SYLVAIN MEILLE¹, JéRôME CHEVALIER¹, DAVID MITTON⁶

BIOCELL, Vol.46, No.10, pp. 2209-2216, 2022, DOI:10.32604/biocell.2022.022290

Abstract To develop durable bone healing strategies through improved control of bone repair, it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and implants. Bone mechanical integrity is defined here as the adaptation of structural properties of remodeled bone in regard to an applied mechanical loading. Accordingly, the authors present why future investigations in bone repair and regeneration should emphasize on the matrix surrounding the osteocytes. Osteocytes are mechanosensitive cells considered as the orchestrators of bone remodeling, which is the biological process involved in bone homeostasis. These bone cells are trapped in… More >

Mahmood Hameed Majeed^*, Nabeel Kadhem Abd Alsaheb

Journal of Renewable Materials, Vol.10, No.9, pp. 2391-2408, 2022, DOI:10.32604/jrm.2022.019887

Abstract Tissue engineering’s main goal is to regenerate or replace tissues or organs that have been destroyed by disease, injury, or congenital disabilities. Tissue engineering now uses artificial supporting structures called scaffolds to restore damaged tissues and organs. These are utilized to attach the right cells and then grow them. Rapid prototyping appears to be the most promising technology due to its high level of precision and control. Bone tissue replacement “scaffolding” is a common theme discussed in this article. The fused deposition technique was used to construct our scaffold, and a polymer called polylactic acids and soybean oil resin were… More > Graphic Abstract

XIAOFANG WANG¹, XIAOLIN TU^1,2,*, YUFEI MA¹, JIE CHEN¹, YANG SONG³, GUANGLIANG LIU¹

BIOCELL, Vol.46, No.9, pp. 2089-2099, 2022, DOI:10.32604/biocell.2022.020069

Abstract The limited bioactivity of scaffold materials is an important factor that restricts the development of bone tissue engineering. Wnt3a activates the classic Wnt/β-catenin signaling pathway which effects bone growth and development by the accumulation of β-catenin in the nucleus. In this study, we fabricated 3D printed PCL scaffold with Wnt3a-induced murine bone marrow-derived stromal cell line ST2 decellularized matrix (Wnt3a-ST2-dCM-PCL) and ST2 decellularized matrix (ST2-dCM-PCL) by freeze-thaw cycle and DNase decellularization treatment which efficiently decellularized >90% DNA while preserved most protein. Compared to ST2-dCM-PCL, Wnt3a-ST2-dCM-PCL significantly enhanced newly-seeded ST2 proliferation, osteogenic differentiation and upregulated osteogenic marker genes alkaline phosphatase (Alp),… More >

XUYI WANG¹, WEN ZHANG², LEI GAO², KUANXIN LI^1,3,*

BIOCELL, Vol.46, No.9, pp. 2065-2072, 2022, DOI:10.32604/biocell.2022.018265

Abstract Background: Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, and there is currently no effective treatment for SCI because of its complicated pathophysiology. Bone marrow mesenchymal stem cells (BMSCs) have multidirectional differentiation abilities. Our study aims to explore the effects of bone morphogenetic protein 7 (BMP-7)-modified BMSCs transplantation on the repair of SCI in rats. Methods: In this study, a rat spinal cord injury model was established with the modified Allen method. Then, BMSCs transfected with the BMP7 gene were transplanted to treat the spinal cord injury in rats. Forty Sprague-Dawley rats were randomly… More >

Khadija Khan, Samabia Tehsin^*

Journal on Artificial Intelligence, Vol.4, No.1, pp. 1-13, 2022, DOI:10.32604/jai.2022.028092

Abstract Leukemia is the cancer that starts in the blood cells due to the excess production of immature leucocytes that replace the cells with normal blood cells. Physicians rely on their experience to determine the type and subtype of Leukemia from the blood sample. Most people are misdiagnosed when it comes to its subtypes, the error rates can be up to 40% during the classification process. That too depends on the expertise of the physician. This research represents a Convolutional Neural Network based medical image classifier. The proposed technique can classify Leukemia and its five subtypes. State of the art deep… More >

Lei Zhang^1,2,*, Shouzhi Huang^1,2, Zhaocai Du³, Guangyao Ouyang^1,2, Heping Chen⁴

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 4817-4832, 2022, DOI:10.32604/cmc.2022.026845

Abstract In this study, a hyper-redundant manipulator was designed for detection and searching in narrow spaces for aerospace and earthquake rescue applications. A forward kinematics equation for the hyper-redundant manipulator was derived using the homogeneous coordinate transformation method. Based on the modal function backbone curve method and the known path, an improved modal method for the backbone curves was proposed. First, the configuration of the backbone curve for the hyper-redundant manipulator was divided into two parts: a mode function curve segment of the mode function and a known path segment. By changing the discrete points along the known path, the backbone… More >