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  • Open Access

    ARTICLE

    CVIP-Net: A Convolutional Neural Network-Based Model for Forensic Radiology Image Classification

    Syeda Naila Batool, Ghulam Gilanie*

    CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 1319-1332, 2023, DOI:10.32604/cmc.2023.032121 - 22 September 2022

    Abstract Automated and autonomous decisions of image classification systems have essential applicability in this modern age even. Image-based decisions are commonly taken through explicit or auto-feature engineering of images. In forensic radiology, auto decisions based on images significantly affect the automation of various tasks. This study aims to assist forensic radiology in its biological profile estimation when only bones are left. A benchmarked dataset Radiology Society of North America (RSNA) has been used for research and experiments. Additionally, a locally developed dataset has also been used for research and experiments to cross-validate the results. A Convolutional… More >

  • Open Access

    CASE REPORT

    Gastric Cancer with Bone Marrow Invasion and Disseminated Intravascular Coagulation: A Case Report

    Lilan Chen, Lu Lu, Xinlei Gong, Yichen Xu, Xiaoyuan Chu*, Guichun Huang*

    Oncologie, Vol.24, No.3, pp. 599-604, 2022, DOI:10.32604/oncologie.2022.023310 - 19 September 2022

    Abstract Gastric cancer is the fifth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide in 2020. Gastric cancer usually undergoes lymph node metastasis and implantation metastasis, but bone metastasis and bone marrow invasion are rare. However, gastric cancer patients with bone marrow invasion usually have cancer emergency, so special attention should be paid in clinical practice. Herein, we analyzed the clinical characteristics of an asian gastric cancer patient with bone marrow invasion and disseminated intravascular coagulation (DIC) in our hospital and summarized the diagnosis and treatment experience to provide a reference More >

  • Open Access

    ARTICLE

    Metaheuristic with Deep Learning Enabled Biomedical Bone Age Assessment and Classification Model

    Mesfer Al Duhayyim1,*, Areej A. Malibari2, Marwa Obayya3, Mohamed K. Nour4, Ahmed S. Salama5, Mohamed I. Eldesouki6, Abu Sarwar Zamani7, Mohammed Rizwanullah7

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5473-5489, 2022, DOI:10.32604/cmc.2022.031976 - 28 July 2022

    Abstract The skeletal bone age assessment (BAA) was extremely implemented in development prediction and auxiliary analysis of medicinal issues. X-ray images of hands were detected from the estimation of bone age, whereas the ossification centers of epiphysis and carpal bones are important regions. The typical skeletal BAA approaches remove these regions for predicting the bone age, however, few of them attain suitable efficacy or accuracy. Automatic BAA techniques with deep learning (DL) methods are reached the leading efficiency on manual and typical approaches. Therefore, this study introduces an intellectual skeletal bone age assessment and classification with… More >

  • Open Access

    ARTICLE

    Construction of Customized Bio Incubator and Designing of Tailored Scaffolds for Bone Tissue Engineering from Laboratory Scale Up to Clinical Scale

    Soliman Abdalla1,2,*, Shiref Kandil2

    Journal of Renewable Materials, Vol.10, No.11, pp. 2699-2716, 2022, DOI:10.32604/jrm.2022.022334 - 29 June 2022

    Abstract In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get More >

  • Open Access

    ARTICLE

    A nanostructured look of collagen apatite porosity into human mineralized collagen fibril

    FABIANO BINI1,*, ANDRADA PICA1, ANDREA MARINOZZI2, FRANCO MARINOZZI1

    BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150 - 13 June 2022

    Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization More >

  • Open Access

    VIEWPOINT

    Osteocyte pericellular and perilacunar matrices as markers of bone–implant mechanical integrity

    RéMY GAUTHIER1,*, HéLèNE FOLLET2, ANA-MARIA TRUNFIO-SFARGHIU3, DELPHINE FARLAY2, NINA ATTIK4,5, SYLVAIN MEILLE1, JéRôME CHEVALIER1, DAVID MITTON6

    BIOCELL, Vol.46, No.10, pp. 2209-2216, 2022, DOI:10.32604/biocell.2022.022290 - 13 June 2022

    Abstract To develop durable bone healing strategies through improved control of bone repair, it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and implants. Bone mechanical integrity is defined here as the adaptation of structural properties of remodeled bone in regard to an applied mechanical loading. Accordingly, the authors present why future investigations in bone repair and regeneration should emphasize on the matrix surrounding the osteocytes. Osteocytes are mechanosensitive cells considered as the orchestrators of bone remodeling, which is the biological process involved in bone homeostasis. These… More >

  • Open Access

    ARTICLE

    Morphological Evaluation of PLA/Soybean Oil Epoxidized Acrylate Three-Dimensional Scaffold in Bone Tissue Engineering

    Mahmood Hameed Majeed*, Nabeel Kadhem Abd Alsaheb

    Journal of Renewable Materials, Vol.10, No.9, pp. 2391-2408, 2022, DOI:10.32604/jrm.2022.019887 - 30 May 2022

    Abstract Tissue engineering’s main goal is to regenerate or replace tissues or organs that have been destroyed by disease, injury, or congenital disabilities. Tissue engineering now uses artificial supporting structures called scaffolds to restore damaged tissues and organs. These are utilized to attach the right cells and then grow them. Rapid prototyping appears to be the most promising technology due to its high level of precision and control. Bone tissue replacement “scaffolding” is a common theme discussed in this article. The fused deposition technique was used to construct our scaffold, and a polymer called polylactic acids… More > Graphic Abstract

    Morphological Evaluation of PLA/Soybean Oil Epoxidized Acrylate Three-Dimensional Scaffold in Bone Tissue Engineering

  • Open Access

    ARTICLE

    Wnt3a-induced ST2 decellularized matrix ornamented PCL scaffold for bone tissue engineering

    XIAOFANG WANG1, XIAOLIN TU1,2,*, YUFEI MA1, JIE CHEN1, YANG SONG3, GUANGLIANG LIU1

    BIOCELL, Vol.46, No.9, pp. 2089-2099, 2022, DOI:10.32604/biocell.2022.020069 - 18 May 2022

    Abstract The limited bioactivity of scaffold materials is an important factor that restricts the development of bone tissue engineering. Wnt3a activates the classic Wnt/β-catenin signaling pathway which effects bone growth and development by the accumulation of β-catenin in the nucleus. In this study, we fabricated 3D printed PCL scaffold with Wnt3a-induced murine bone marrow-derived stromal cell line ST2 decellularized matrix (Wnt3a-ST2-dCM-PCL) and ST2 decellularized matrix (ST2-dCM-PCL) by freeze-thaw cycle and DNase decellularization treatment which efficiently decellularized >90% DNA while preserved most protein. Compared to ST2-dCM-PCL, Wnt3a-ST2-dCM-PCL significantly enhanced newly-seeded ST2 proliferation, osteogenic differentiation and upregulated osteogenic More >

  • Open Access

    ARTICLE

    Transplantation of BMP-7 gene-transfected bone marrow mesenchymal stem cells for the treatment of spinal cord injury in rats

    XUYI WANG1, WEN ZHANG2, LEI GAO2, KUANXIN LI1,3,*

    BIOCELL, Vol.46, No.9, pp. 2065-2072, 2022, DOI:10.32604/biocell.2022.018265 - 18 May 2022

    Abstract Background: Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, and there is currently no effective treatment for SCI because of its complicated pathophysiology. Bone marrow mesenchymal stem cells (BMSCs) have multidirectional differentiation abilities. Our study aims to explore the effects of bone morphogenetic protein 7 (BMP-7)-modified BMSCs transplantation on the repair of SCI in rats. Methods: In this study, a rat spinal cord injury model was established with the modified Allen method. Then, BMSCs transfected with the BMP7 gene were transplanted to treat the spinal cord injury in rats. Forty… More >

  • Open Access

    ARTICLE

    Classification of Bone Marrow Cells for Medical Diagnosis of Acute Leukemia

    Khadija Khan, Samabia Tehsin*

    Journal on Artificial Intelligence, Vol.4, No.1, pp. 1-13, 2022, DOI:10.32604/jai.2022.028092 - 16 May 2022

    Abstract Leukemia is the cancer that starts in the blood cells due to the excess production of immature leucocytes that replace the cells with normal blood cells. Physicians rely on their experience to determine the type and subtype of Leukemia from the blood sample. Most people are misdiagnosed when it comes to its subtypes, the error rates can be up to 40% during the classification process. That too depends on the expertise of the physician. This research represents a Convolutional Neural Network based medical image classifier. The proposed technique can classify Leukemia and its five subtypes. More >

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