Oncology Research Editorial Office

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.081623 - 22 April 2026

Abstract This article has no abstract. More >

Cong Liu¹, Zhenyu Zhang¹, Ronghua Feng¹, Mengsi Zeng¹, Hui Li¹, Mei Zhu¹, Lan Zhuang^2,*, Zongjuan Li^1,*, Tao Wu^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.077059 - 22 April 2026

Abstract Background: Breast cancer is the leading cause of cancer-related deaths in women, primarily due to distant metastasis. Metabolic reprogramming plays a critical role in tumor growth and spread, but the metabolic mechanisms underlying metastasis in breast cancer remain unclear. The primary objective of this study is to identify molecular targets mediating breast cancer progression and to evaluate whether targeting the metabolic reprogramming represents a potential therapeutic strategy. Methods: To uncover key metabolic regulators involved in breast cancer progression, we analyzed high-throughput RNA sequencing data and identified Paired Like Homeodomain 1 (PITX1) as a frequently upregulated… More >

Nevena Todorovic^1,#, Sara Bertorello^1,#, Giulia Nannini¹, Serena Pillozzi², Simonetta Bianchi³, Maria Raffaella Ambrosio⁴, Elena Niccolai¹, Simone Baldi¹, Amedeo Amedei^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076380 - 22 April 2026

Abstract Background: Cancer remains one of the leading global health challenges, with lung cancer (LC), breast cancer (BC), and colorectal cancer (CRC) among the most prevalent and deadly malignancies. The intratumoral microbiota (IM), a distinct microbial ecosystem within tumor tissues, has recently emerged as a potential modulator of carcinogenesis, immune responses, and metastatic progression. However, comparative cross-cancer analyses remain limited. Therefore, this study aimed to compare the IM across these cancer types, with particular emphasis on distinguishing metastatic from non-metastatic malignancies, to identify tumor-specific microbial signatures with potential relevance for biomarker discovery, patient stratification, and microbiota-informed… More >

Yu-Hao Huang¹, Yu-Ci Tu¹, Peng-Ju Chien^1,2, An-Jie Lee¹, Chia-Liang Lin³, Shao-Ti Li⁴, Yueh-Chun Lee^4,5,*, Wen-Wei Chang^1,6,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.075190 - 22 April 2026

Abstract Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and resistance to conventional therapies, including radiotherapy. Cancer stem cells (CSCs) drive tumor initiation, metastasis, and therapy resistance in TNBC. Identifying pathways sustaining CSCs in radioresistant TNBC is key for targeted therapies. This study examines SRC proto-oncogene (SRC) and the signal transducer and activator of transcription 3 (STAT3) activation in radioresistance and CSC maintenance. Methods: A radioresistant MDA-MB-231 TNBC cell line (231RR) was developed and compared to the parental line for CSC activity and self-renewal. Western blotting assessed molecular changes; functional assays followed… More >

Evangelos Manousakis¹, Cristina Moreta-Moraleda¹, Clàudia Martinez Miralles¹, Anna Tomàs Pujolà¹, Houda Baccara², Laia Liñán Franquet¹, Montserrat Montañés Albó¹, Roberto Ferrari², Roni H. G. Wright^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074965 - 22 April 2026

Abstract Objective: Breast cancer remains one of the most prevalent malignancies among women worldwide, and despite advances in therapy and treatment options, tumour relapse and metastasis remain major clinical challenges, largely driven by the breast cancer stem cells (BCSCs) niche that resists conventional treatments and regenerates tumours. In breast cancer, where approximately 30% of patients who initially respond to treatment ultimately relapse and die of metastatic disease, targeting BCSCs is critical for improving patient outcomes. Cyclin-dependent kinase inhibitor 1A/p21 (CDKN1A/p21) is a multifunctional protein that is known primarily for its role in regulating the cell cycle… More > Graphic Abstract

Luigi Coltelli^1,2,#, Paola Orlandi^3,#, Chiara Finale^1,4,#, Gianna Musettini^1,4,#, Luna Chiara Masini^1,4, Marco Scalese⁵, Giulia Soria^1,4, Elena Sartori^1,4, Ylenia Nodari^1,4, Giada Arrighi^1,2, Arianna Bandini³, Marta Banchi³, Costanza Tacchi³, Donghao Tang³, Barbara Salvadori⁶, Lucia Tanganelli^1,7, Simona Giovannelli^1,8, Mirco Pistelli⁹, Samanta Cupini^1,4, Maurizio Lucchesi^1,10, Alessandro Cosimi¹¹, Giulia Lorenzini^1,7, Elisa Biasco^1,4, Chiara Caparello^1,4, Giulia Acconci^1,4,6, Eloise Fontana^1,4, Eleonora Bona^1,4, Azzurra Farnesi^1,4, Antonio Pellino^1,4, Andrea Marini^1,4, Ermelinda De Maio^1,4, Irene Stasi^1,4, Cecilia Barbara^1,4, Enrico Sammarco^1,4, Javier Rosada^12,13, Giacomo Allegrini^1,4,*, Guido Bocci^3,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.073799 - 22 April 2026

Abstract Background: The treatment of advanced hormone receptor-positive (HR+) breast cancer has seen relevant changes in last years. However, bevacizumab remains an option when combined with paclitaxel, but no certified pharmacogenetic profiles are now usable for the prediction of its response in breast cancer patients. This study aimed to explore the pharmacogenetic interactions among single nucleotide polymorphisms (SNPs) of genes involved in the angiogenic process and their impact on progression-free survival (PFS) and overall survival (OS) in hormone receptor-positive (HR+) metastatic breast cancer subjects administered with bevacizumab plus paclitaxel, or with paclitaxel alone (clinicaltrial.gov… More >

Haojie Yang^1,2,#, Zicong Tan^1,2,#, Zihao Liu^3,#, Kang Chen^1,2, Ning Liufu^1,2,*, Fengtao Ji^1,2,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.073081 - 22 April 2026

Abstract Background: Circular RNAs (circRNAs) play a crucial role in the progression of malignant tumors such as breast cancer. Methods: A circRNA microarray was used to detect key circRNAs in breast cancer. Expression of Circ72688 was verified by quantitative reverse transcription PCR (qRT-PCR) and fluorescence in situ hybridization (FISH) assay. Transwell assay and in vivo assay were conducted to prove the function of Circ72688. Exploring the downstream mechanism, dual-luciferase reporter assay, western blotting, and tissue microarray were performed. Results: We sequenced and identified a circRNA, hsa-circ-0072688, also known as Circ72688. Our research found that Circ72688 enhanced tumor metastasis both More >

Denisse A. Gutierrez^*, Elisa Robles-Escajeda, Jose A. Lopez-Saenz, Robert A. Kirken, Edgar A. Borrego, Ana P. Betancourt, Soumya Nair, Sourav Roy, Armando Varela-Ramirez, Renato J. Aguilera^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074945 - 23 March 2026

Abstract Objectives: Drug resistance is the major determinant of chemotherapy failure, leading to relapse and tumor progression, demonstrating the urgent need for novel antineoplastic drugs. This study aimed to evaluate the anticancer potential of two novel pyrazole derivatives, P3C.1 and P3C.2, and to elucidate their mechanism of action in cancer cells. Methods: The cytotoxicity of the compounds was evaluated across 27 different cancer cell lines via a nuclear staining assay. Subsequent flow cytometric and biochemical analyses were performed to assess reactive oxygen species (ROS) generation, apoptosis induction, mitochondrial integrity, and cell cycle progression. Additional studies included… More >

Francisco Raúl Borzone^1,2,*, María Belén Giorello¹, Agustina Freire³, Leandro Marcelo Martinez⁴, Leonardo Feldman⁵, Federico Dimase⁶, Pablo Evelson³, Irene Larripa⁷, Emilio Batagelj⁸, Marcela Beatriz González Cid⁹, Norma Alejandra Chasseing^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074321 - 23 March 2026

Abstract Backgrounds: Breast cancer metastasis remains the leading cause of mortality and frequently targets the bone. Breast cancer cells release soluble factors and extracellular vesicles that disrupt bone marrow (BM)/bone homeostasis, promoting osteoclastogenesis and the accumulation of senescent cells. In line with updated cancer hallmarks, senescent mesenchymal stem/ stromal cells (MSCs), osteoblasts, and osteocytes contribute to remodeling of the BM microenvironment, thereby favoring pre-metastatic niche (PMN) formation and subsequent bone metastasis. We previously demonstrated that untreated stage III-B breast cancer patients (BCPs) exhibit increased oxidative stress and elevated reactive oxygen species (ROS) levels, accompanied by senescent… More > Graphic Abstract

Mohsina Patwekar^1,2, Faheem Patwekar³, Zulhisyam Abdul Kari^1,4,*, Muhammad Rajaei Ahmad Mohd Zain^5,*, Arifullah Mohammed⁶, Rohit Sharma^7,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073601 - 23 March 2026

Abstract Breast cancer remains the primary cause of cancer-related mortality for women globally; therefore, further breakthroughs in treatment approaches are crucial. Palbociclib, ribociclib, and abemaciclib are among the Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors that have become an innovative family of targeted therapy for hormone receptor-positive, Human Epidermal Growth factor receptor 2 (HR+/HER2−) breast cancer. These inhibitors work by preventing the action of CDK4/6, which are crucial in the regulation of the cell cycle. Leading cancer cells to cell cycle arrest and undergo apoptosis. When these inhibitors are used with endocrine medicines like letrozole and… More > Graphic Abstract