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Search Results (222)
  • Open Access

    ARTICLE

    OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6

    YU QIU1,#, RUIHAN LIU2,#, SHANSHAN HUANG1, QIAOTING CAI1, YI XIE1, ZHITING HE1, WEIGE TAN2,*, XINHUA XIE1,*

    Oncology Research, Vol.33, No.5, pp. 1135-1147, 2025, DOI:10.32604/or.2025.062767 - 18 April 2025

    Abstract Objectives: Deubiquitinase OTUB2 plays a critical role in the progression of various tumors. However, its specific role in triple-negative breast cancer (TNBC) remains unclear. This study aims to elucidate the biological function of OTUB2 in TNBC and uncover the underlying mechanisms. Methods: First, we found that the expression of OTUB2 was upregulated in TNBC by bioinformatics analysis, we then validated its expression in TNBC tissues and cells using immunohistochemistry (IHC) and qPCR and plotted the survival curves by Kaplan-Meier method. Gene set enrichment analysis (GSEA) suggested that OTUB2 may be involved in tumor proliferation and metastasis.… More > Graphic Abstract

    OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6

  • Open Access

    ARTICLE

    UltraSegNet: A Hybrid Deep Learning Framework for Enhanced Breast Cancer Segmentation and Classification on Ultrasound Images

    Suhaila Abuowaida1,*, Hamza Abu Owida2, Deema Mohammed Alsekait3,*, Nawaf Alshdaifat4, Diaa Salama AbdElminaam5,6, Mohammad Alshinwan4

    CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 3303-3333, 2025, DOI:10.32604/cmc.2025.063470 - 16 April 2025

    Abstract Segmenting a breast ultrasound image is still challenging due to the presence of speckle noise, dependency on the operator, and the variation of image quality. This paper presents the UltraSegNet architecture that addresses these challenges through three key technical innovations: This work adds three things: (1) a changed ResNet-50 backbone with sequential 3 convolutions to keep fine anatomical details that are needed for finding lesion boundaries; (2) a computationally efficient regional attention mechanism that works on high-resolution features without using a transformer’s extra memory; and (3) an adaptive feature fusion strategy that changes local and… More >

  • Open Access

    REVIEW

    Targeting MDM2-p53 interaction for breast cancer therapy

    AMJAD YOUSUF1, NAJEEB ULLAH KHAN2,*

    Oncology Research, Vol.33, No.4, pp. 851-861, 2025, DOI:10.32604/or.2025.058956 - 19 March 2025

    Abstract Breast cancer is a significant global concern, with limited effective treatment options. Therefore, therapies with high efficacy and low complications, unlike the existing chemotherapies, are urgently required. To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction. This review aims to investigate the efficacy of MDM2 inhibition in restoring TP53 activity in breast cancer cells, as evidenced by clinical studies, reviews, and trials. TP53 is a tumor suppressor and MDM2 facilitates proteasomal degradation of TP53. MDM2 and TP53 activity More > Graphic Abstract

    Targeting MDM2-p53 interaction for breast cancer therapy

  • Open Access

    RETRACTION

    Retraction: Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.4, pp. 989-989, 2025, DOI:10.32604/or.2024.056912 - 19 March 2025

    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    Cancer stem cell specificity as new targets in breast tumor treatment

    ZHIZHENG ZHANG1,#, TAO LI2,#, YUAN LI3, XI WANG4, HAO LIU5, XINYU SHEN5, ANN XU6, TIANSONG XIA1,*, BO XU7,*

    Oncology Research, Vol.33, No.4, pp. 811-819, 2025, DOI:10.32604/or.2024.050505 - 19 March 2025

    Abstract Background: Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy. Methods: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as “breast cancer stem cells,” “immunotherapy,” “gene therapy,” and “cell therapy.” Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells. Results: Breast cancer stem cells exhibit unique properties More >

  • Open Access

    ARTICLE

    A Secured and Continuously Developing Methodology for Breast Cancer Image Segmentation via U-Net Based Architecture and Distributed Data Training

    Rifat Sarker Aoyon1, Ismail Hossain2, M. Abdullah-Al-Wadud3, Jia Uddin4,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.3, pp. 2617-2640, 2025, DOI:10.32604/cmes.2025.060917 - 03 March 2025

    Abstract This research introduces a unique approach to segmenting breast cancer images using a U-Net-based architecture. However, the computational demand for image processing is very high. Therefore, we have conducted this research to build a system that enables image segmentation training with low-power machines. To accomplish this, all data are divided into several segments, each being trained separately. In the case of prediction, the initial output is predicted from each trained model for an input, where the ultimate output is selected based on the pixel-wise majority voting of the expected outputs, which also ensures data privacy.… More >

  • Open Access

    RETRACTION

    Retraction: MYBL2 is targeted by miR-143-3p and regulates breast cancer cell proliferation and apoptosis

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.3, pp. 739-739, 2025, DOI:10.32604/or.2024.056911 - 28 February 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Ultrasound genomics related mitochondrial gene signature for prognosis and neoadjuvant chemotherapy resistance in triple negative breast cancer

    HUAFANG HUANG1,2,#, GUILIN WANG3,#, DONGYUN ZENG4,5, LUZ ANGELA TORRES-DE LA ROCHE2, RUI ZHUO1,2, RUDY LEON DE WILDE2, WANWAN WANG6, ULF D. KAHLERT7,*, WENJIE SHI7,*

    Oncology Research, Vol.33, No.3, pp. 631-640, 2025, DOI:10.32604/or.2024.054642 - 28 February 2025

    Abstract Background: Neoadjuvant chemotherapy (NAC) significantly enhances clinical outcomes in patients with triple-negative breast cancer (TNBC); however, chemoresistance frequently results in treatment failure. Consequently, understanding the mechanisms underlying resistance and accurately predicting this phenomenon are crucial for improving treatment efficacy. Methods: Ultrasound images from 62 patients, taken before and after neoadjuvant therapy, were collected. Mitochondrial-related genes were extracted from a public database. Ultrasound features associated with NAC resistance were identified and correlated with significant mitochondrial-related genes. Subsequently, a prognostic model was developed and evaluated using the GSE58812 dataset. We also assessed this model alongside clinical factors… More >

  • Open Access

    ARTICLE

    Magnetic melamine cross-linked polystyrene-alt-malic anhydride copolymer: Synthesis, characterization, paclitaxel delivery, cytotoxic effects on human ovarian and breast cancer cells

    RAZIEH MOMEN-MESGIN1, JAFAR REZAIE2,*, VAHID NEJATI1, PEYMAN NAJAFI MOGHADAM3

    Oncology Research, Vol.33, No.3, pp. 665-674, 2025, DOI:10.32604/or.2024.054487 - 28 February 2025

    Abstract Objectives: Due to systematic side effects, there is a growing interest in nanoparticle formulation of anticancer drugs. Here, we aimed to synthesize poly (styrene-alt-maleic anhydride) cross-linked by melamine (PSMA/Me) and coated with magnetite nanoparticles (MNPs) PSMA/Me/Fe3O4. In addition, we aimed to load paclitaxel (PTX) into PSMA/Me/Fe3O4 for drug delivery and anticancer investigations. Methods: Novel PSMA/Me was synthesized via free radical copolymerization, coated with Fe3O4, and then used as a transporter for PTX delivery. Fabricated copolymer was characterized using SEM, TGA, and XRD techniques. Drug release rate and loading efficiency were investigated. Human ovarian cancer cells (Skov-3) and… More >

  • Open Access

    ARTICLE

    Preventive effects of low-dose radiation and hypofractionated radiation plus anti-programmed cell death protein 1 on lung metastasis in breast cancer

    SHUANG CHEN1,2,#, XUEMEI DENG2,#, XINGTING HE2, KEWEI XIANG2, GUIHONG CHEN2, HONGRU YANG2,*

    Oncology Research, Vol.33, No.3, pp. 687-694, 2025, DOI:10.32604/or.2024.052133 - 28 February 2025

    Abstract Background: Previous experiments have demonstrated that hypofractionated radiation therapy (HFRT), low-dose radiation therapy (LDRT), and combined anti-programmed cell death protein 1 (αPD-1) can enhance the abscopal effect. Combined with the phenomenon of low prognosis in patients with breast cancer lung metastasis, our study establishes a mouse model and changes the irradiation regimen of LDRT to explore its preventive effect on breast cancer lung metastasis. Methods: The breast cancer subcutaneous graft tumor model was developed. Two-lung prophylactic LDRT was performed prior to the onset of lung metastases, in combination with HFRT (8 Gy, 3f), and αPD-1… More >

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