Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086722 - 16 June 2026

Abstract This article has no abstract. More >

Liang Li^1,#, Huijuan Liu^1,#, Lianjiang Du², Pan Xi¹, Qian Wang¹, Yanqin Li³, Di Liu^4,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086717 - 16 June 2026

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.081623 - 22 April 2026

Abstract This article has no abstract. More >

Yu-Hao Huang¹, Yu-Ci Tu¹, Peng-Ju Chien^1,2, An-Jie Lee¹, Chia-Liang Lin³, Shao-Ti Li⁴, Yueh-Chun Lee^4,5,*, Wen-Wei Chang^1,6,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.075190 - 22 April 2026

Abstract Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and resistance to conventional therapies, including radiotherapy. Cancer stem cells (CSCs) drive tumor initiation, metastasis, and therapy resistance in TNBC. Identifying pathways sustaining CSCs in radioresistant TNBC is key for targeted therapies. This study examines SRC proto-oncogene (SRC) and the signal transducer and activator of transcription 3 (STAT3) activation in radioresistance and CSC maintenance. Methods: A radioresistant MDA-MB-231 TNBC cell line (231RR) was developed and compared to the parental line for CSC activity and self-renewal. Western blotting assessed molecular changes; functional assays followed… More >

Chanwoong Yoon^1,#, Euihyeon Na^2,#, Min Joo Choi¹, Sang-Pil Yoon^1,3,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074140 - 22 April 2026

Abstract Objective: Increased Src kinase activity is known to correlate with cancer progression and poor prognosis, indicating that Src plays a central role in cell migration and invasion. In this study, we investigated the effects of saracatinib, a Src kinase inhibitor, under anoikis-resistant conditions in colorectal cancer cells. Methods: Wild-type and 5-fluorouracil-resistance acquired SNU-C5 colorectal cancer cells were cultured in both monolayer and spheroid systems under fetal bovine serum (FBS) or growth factor (GF) supplemented conditions. Cell viability assay, flow cytometry, wound healing assay, spheroid formation and morphometric analysis, and Western blotting were performed using both… More >

Crystal J. Byrd¹, Monasia Evans¹, Woojung Kim², Quintera Knight³, Geou-Yarh Liou^1,2,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.073532 - 23 March 2026

Abstract Objective: The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment. Within this microenvironment, infiltrating immune cells, such as B cells, can be either anti-tumorigenic or pro-tumorigenic. Our preliminary data showed that a higher density of the infiltrating B cells was found near prostate cancer cells in human cancer tissues, as compared to the benign prostate tissue regions, thus suggesting that infiltrating B cells would promote the progression of prostate cancer cells. In this study, we aim to investigate the role of infiltrating B cells in enhancing the migratory ability of… More >

Yen-Pin Chen^1,2,3, Rathinasamy Baskaran⁴, Hema Sri Devi⁴, Chaouhan Hitesh Singh⁴, Yu-Jung Lin^4,5, Marthandam Asokan Shibu⁶, Wei-Wen Kuo⁷, Shih-Chieh Liao⁸, Ming-Cheng Chen⁹, Tso-Fu Wang¹⁰, Chi-Cheng Li¹¹, Tsung-Jung Ho¹², Tzu-Ching Shih¹³, Shinn-Zong Lin^14,15,16,*, Chih-Yang Huang^4,17,18,19,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073080 - 23 March 2026

Abstract Objective: MicroRNAs (miRNAs) are small, non-coding RNAs that play a key role in the development of chemoresistance in various cancer types, including colorectal cancer (CRC). In this study, we aimed to study the underlying mechanisms of miRNA in chemotherapy-resistant CRC. Methods: LoVo CRC cell line was exposed to oxaliplatin at an increased dose, and cells were cultured in the presence of oxaliplatin to develop LoVoOXR cells. Microarray and Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), western blot, and transwell assay were used to evaluate the chemoresistance in LoVo^OXR CRC cells. Results: Microarray and qRT-PCR analysis showed… More >

Norbert Nass^1,2,*, Atanas Ignatov³, Thomas Kalinski¹

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072793 - 24 February 2026

Abstract Objectives: Vascular endothelial growth factor (VEGF) regulates tumor vascularization in response to hypoxia and inflammatory signals. The polyphenol curcumin is supposed to interfere with inflammation-induced VEGF secretion and might therefore support anti-VEGF-based treatments. We aimed to investigate the interaction between curcumin and the inflammatory cytokine Interleukin-1β (IL-1β) for VEGF secretion in breast cancer cell lines representing major breast cancer subtypes. Methods: VEGF in cell cultures was detected by Western blot and enzyme-linked immunosorbent assay (ELISA). Kinase phosphorylation was investigated by Western blotting. Gene expressions were analyzed by correlation tests. VEGF was evaluated in a retrospective… More > Graphic Abstract

Oncology Research Editorial Office

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.078459 - 19 January 2026

Abstract This article has no abstract. More >

Sha Hu^1,2,#, Wenjing Wang^1,#, Qianfang Hu^3,#, Rujuan Zheng^1,2, Qinghe Huang^1,2, Hui Shi^1,2, Xinyuan Ding^3,*, Wenjuan Wang^1,2,*, Zengyan Zhu^1,2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.068967 - 19 January 2026

Abstract Objectives: Acquired resistance to paclitaxel represents a critical barrier to the effective chemotherapy of non-small cell lung cancer (NSCLC). The present study aimed to elucidate the molecular and pharmacological mechanisms promoting paclitaxel resistance in NSCLC and to explore potential strategies for overcoming this resistance. Methods: Here, we report an integrated pharmacological and analytical approach to quantify paclitaxel disposition and overcome resistance in a A549/TAX cell model (paclitaxel-resistant A549 cells). Results: Cell counting kit-8 (CCK-8) assay, colony formation, and apoptosis assays confirmed that A549/TAX cells exhibited marked resistance to paclitaxel relative to parental A549 cells. Based on… More >