Sun Park^*, JongWon Kim

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072865 - 12 January 2026

Abstract In real-world autonomous driving tests, unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur. Conducting actual test drives under various weather conditions may also lead to dangerous situations. Furthermore, autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS. Driving simulators, which replicate driving conditions nearly identical to those in the real world, can drastically reduce the time and cost required for market entry validation; consequently, they have become widely used. In this paper, we design a virtual driving test environment capable of More >

Chao Li^1,3,#, Jianing Wang^1,3,#, Caichang Ding^2,*, Zhiwei Ye^1,3

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.071242 - 12 January 2026

Abstract Underwater images frequently suffer from chromatic distortion, blurred details, and low contrast, posing significant challenges for enhancement. This paper introduces AquaTree, a novel underwater image enhancement (UIE) method that reformulates the task as a Markov Decision Process (MDP) through the integration of Monte Carlo Tree Search (MCTS) and deep reinforcement learning (DRL). The framework employs an action space of 25 enhancement operators, strategically grouped for basic attribute adjustment, color component balance, correction, and deblurring. Exploration within MCTS is guided by a dual-branch convolutional network, enabling intelligent sequential operator selection. Our core contributions include: (1) a More >

Ahsan Habib Siam¹, Md. Ehsanul Haque¹, Fahmid Al Farid², Anindita Sutradhar³, Jia Uddin^4,*, Sarina Mansor^2,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.069718 - 12 January 2026

Abstract As healthcare systems increasingly embrace digitalization, effective management of electronic health records (EHRs) has emerged as a critical priority, particularly in inpatient settings where data sensitivity and real-time access are paramount. Traditional EHR systems face significant challenges, including unauthorized access, data breaches, and inefficiencies in tracking follow-up appointments, which heighten the risk of misdiagnosis and medication errors. To address these issues, this research proposes a hybrid blockchain-based solution for securely managing EHRs, specifically designed as a framework for tracking inpatient follow-ups. By integrating QR code-enabled data access with a blockchain architecture, this innovative approach enhances… More >

Samuel Acheme^*, Glory Nosawaru Edegbe

Journal of Cyber Security, Vol.8, pp. 1-31, 2026, DOI:10.32604/jcs.2026.073923 - 07 January 2026

Abstract Federated learning (FL) enables collaborative model training across decentralized datasets, thus maintaining the privacy of training data. However, FL remains vulnerable to malicious actors, posing significant risks in privacy-sensitive domains like healthcare. Previous machine learning trust frameworks, while promising, often rely on resource-intensive blockchain ledgers, introducing computational overhead and metadata leakage risks. To address these limitations, this study presents a novel Decentralized Identity (DID) framework for mutual authentication that establishes verifiable trust among participants in FL without dependence on centralized authorities or high-cost blockchain ledgers. The proposed system leverages Decentralized Identifiers (DIDs) and Verifiable Credentials… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077269 - 30 December 2025

Abstract This article has no abstract. More >

Se Ha Jang^1,2,#, Hyung Seok Kim^3,#, Jung Woo Eun^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072240 - 30 December 2025

Abstract Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and More >

Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

Giacomo Iovane^1,*, Luca Traman², Michele Maffezzoli^1,3, Giuseppe Fornarini², Domenico Corradi⁴, Debora Guareschi⁴, Matteo Santoni^5,#, Sebastiano Buti^1,#

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:… More > Graphic Abstract

Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Yongle Qiu^1,#, Kunshan Li^1,#, Wenjing Wang¹, Wenjuan Zhang², Jilun Liu², Yang Bai³, Fei Xu³, Jie Guo^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069612 - 30 December 2025

Abstract Background: The regulatory mechanisms governing vasculogenic mimicry (VM) in oral squamous cell carcinoma (OSCC) remain largely undefined. This study aimed to identify critical factors and elucidate the epigenetic mechanisms underlying VM in OSCC. Methods: Bioinformatics analysis was performed utilizing single-cell RNA-seq, bulk RNA-seq, and histone H3 lysine 27 acetylation (H3K27ac) Chromatin Immunoprecipitation (ChIP)-seq data obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. ChIP-qPCR was used to validate the binding of ETS transcription factor ELK4 (ELK4) to the dihydrofolate reductase (DHFR) enhancer. In vitro VM formation and invasion of OSCC cells were… More > Graphic Abstract