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  • Open Access

    ARTICLE

    α7nAChR inhibition by methyllycaconitine citrate promotes cell pyroptosis by triggering the polyol pathway in cervical cancer cells

    JUNYING XU1,#, PING LI1,#, GE WANG2, DAQIANG YE1,*, XIUFU TANG3,*

    BIOCELL, Vol.48, No.2, pp. 283-291, 2024, DOI:10.32604/biocell.2023.045429

    Abstract Background: α7 nicotinic acetylcholine receptor (α7nAChR) has been demonstrated to be involved in numerous of inflammatory diseases. Cell pyroptosis is a kind of cell death accompanied by inflammation. Objectives: The objective of this work is to explore the function of α7nAChR on cell pyroptosis in cervical cancer cells. Methods: Immunoblotting, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay were employed to examine the function of α7nAChR on cell pyroptosis and metabolic changes. Results: Herein, we found that α7nAChR inhibition led to cell pyroptosis in HeLa and SiHa of cervical cancer cells, which was attributed to the upregulation of the polyol… More >

  • Open Access

    ARTICLE

    Knockdown Annexin A8 inhibits the proliferation and invasion of cervical cancer cells

    WEILING ZHANG1,2, YONG LI2, CAN ZHANG2, QING HAN2, YU ZHANG2, AIQIN HE2, WEIPEI ZHU1,*

    BIOCELL, Vol.47, No.12, pp. 2697-2708, 2023, DOI:10.32604/biocell.2023.044314

    Abstract Background: This study aimed to explore the expression, function, and molecular mechanism of ANXA8, the gene for annexin 8, in cervical cancer. Methods: The gene expression of the ANX family members in cervical cancer tissues was classified via The Cancer Genome Atlas (TCGA) database. The expression of ANXA8 in paracancerous tissues, cervical cancer tissues, and cell lines was identified by fluorescence quantitative polymerase chain reaction (PCR) and immunohistochemistry. The effects of ANXA8 knockdown on the cellular growth and cell invasion of cervical cancer were examined by MTT, clone-formation assay, scratch test, and Transwell assay. The effect of ANXA8 knockdown on… More >

  • Open Access

    ARTICLE

    SMC1A served as a potential therapeutic target to regulate malignant phenotypes of cervical cancer

    WEILAN LIU, XIAOYAN DUAN, KAIYUN QIN, YAN JIANG, CAIFU ZHAO, CONGWEI DAI*

    BIOCELL, Vol.47, No.11, pp. 2471-2484, 2023, DOI:10.32604/biocell.2023.029617

    Abstract Introduction: Structural maintenance of chromosome 1A (SMC1A) is a crucial compound of the cohesin complex. It has been reported to regulate the epithelial-mesenchymal transition (EMT) process in multiple cancers. Objectives: The present study aims to further clarify the role of SMC1A in cervical cancer. Methods: We analyzed data from four datasets and confirmed that SMC1A showed high expression in cervical cancer samples and was related to poor prognosis of patients with cervical cancer. Cell proliferation of SiHa and C-33A with knockdown of SMC1A was assessed using CCK-8 and colony formation assay. The migration and invasion were estimated by wound healing… More > Graphic Abstract

    SMC1A served as a potential therapeutic target to regulate malignant phenotypes of cervical cancer

  • Open Access

    ARTICLE

    Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells

    YIFAN LI1,2, JING ZHANG1, YITAO FAN1, HANDAN XIAO1, KEXIN KANG1, YALI ZHOU1, ZHIWEN ZHANG3,*, YUMIN LI1, MUZHOU TENG1,*

    BIOCELL, Vol.47, No.8, pp. 1783-1791, 2023, DOI:10.32604/biocell.2023.028056

    Abstract Background: ((1-triphenylaminebenzo[c][1,2,5] thiadiazole-4-yl) styryl)-1-methylpyridin methylpyridin-1-ium iodide salt (TBZPy) is a novel photosensitizer that displays excellent photodynamic properties. However, There are few reports on the mechanism of action of the TBZPy photodynamic. Previous studies revealed that photodynamic therapy (PDT) could induce endoplasmic reticulum stress by acting on the endoplasmic reticulum. Therefore, in this study, we investigated the effects of endoplasmic reticulum stress induced by TBZPy-PDT in treating High-risk human papillomavirus (HR-HPV) infection and their underlying mechanisms. Methods: The human cervical cancer cell line HeLa (containing whole genome of HR-HPV18) was treated with TBZPy-PDT. Cell migration, invasion, and colony-forming ability were evaluated… More > Graphic Abstract

    Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells

  • Open Access

    ARTICLE

    RASAL2 acts as a tumor suppressor in cervical cancer cells

    LI CHEN1,2, FANGFANG LI2, SHOUYAN CAO2, XIA LI2, CHAO ZHOU2, SAI HAN1,*, YOUZHONG ZHANG1,*

    BIOCELL, Vol.47, No.7, pp. 1549-1560, 2023, DOI:10.32604/biocell.2023.027308

    Abstract Background: This study was designed to investigate the roles of RASAL2 in cervical cancer (CC). Methods: Fifty-four CC tissues and 33 adjacent tissues were obtained from CC patients admitted to our hospital between March 2012 and June 2014. Real-time polymerase chain reaction and western blotting were performed to analyze the expression of RASAL2 mRNA and protein in these tissues, CC cell lines, and normal cervical cells. Over-expression and silencing of RASAL2 were induced after transfection, and the migration, invasion, and proliferation of the CC cell lines were examined. Results: RASAL2 mRNA and protein expressions were significantly down-regulated in CC tissues… More >

  • Open Access

    ARTICLE

    Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction

    YUTING WANG1,2,3, PEIWEN FAN1,2,3, YANING FENG1,2,3, XUAN YAO4, YANCHUN PENG4, RUOZHENG WANG1,2,3,*

    BIOCELL, Vol.47, No.6, pp. 1365-1375, 2023, DOI:10.32604/biocell.2023.027201

    Abstract Background: This study was designed to investigate the feasibility of tumor-infiltrating immune cells with different phenotypic characteristics for predicting short-term clinical responses in patients with locally advanced cervical cancer (LACC). Methods: Thirty-four patients who received concurrent chemoradiotherapy and twenty-one patients who merely underwent radiotherapy were enrolled in this study. We retrospectively analyzed the T cell markers (i.e., CD3, CD4, CD8), memory markers (i.e., CD45, CCR7), and differentiation markers (i.e., CD27) in the peripheral blood and tumor tissues of patients with LACC before treatment based on flow cytometry. We also analyzed the relationship of T cell subsets between peripheral blood and… More >

  • Open Access

    ARTICLE

    Raloxifene-loaded and aptamer-bonded exosomes induce autophagic and apoptotic death in HeLa cells by enhancing the lysosomotropic effect

    OMER ERDOGAN1, GULEN MELIKE DEMIRBOLAT2, OZGE CEVIK1,*

    BIOCELL, Vol.47, No.5, pp. 1051-1063, 2023, DOI:10.32604/biocell.2023.028129

    Abstract Background: Raloxifene, a selective estrogen receptor modulator, is also known to be a lysosomotropic agent. The bioavailability of raloxifene is around 2% due to extensive hepatic transport. Exosomes are nanosized vesicles that are naturally released from cells. Method: In this study, exosomes released from HeLa cervical cancer cells were loaded with raloxifene to increase its bioavailability, and an aptamer was attached to the exosome membrane for targeting only HeLa cells. Characterization of exosomes isolated from HeLa cells was performed by transmission electron microscopy, zeta sizer, and western blotting. In addition, the cytotoxic, apoptotic, autophagic, and lysosomotropic effects of the prepared… More >

  • Open Access

    REVIEW

    The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

    PARISA SHIRI AGHBASH1,2,4, NIMA HEMMAT1, BEHZAD BARADARAN1,3, AHAD MOKHTARZADEH1, VAHDAT POORTAHMASEBI2,4, MAHIN AHANGAR OSKUEE2,4, HOSSEIN BANNAZADEH BAGHI1,2,4,*

    Oncology Research, Vol.30, No.3, pp. 99-116, 2022, DOI:10.32604/or.2022.026776

    Abstract Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. The signaling pathways involved in the transformation of normal cells to cancerous form and the subsequently expressed programmed cell death-ligand 1 (PD-L1) on the surface of the transformed cells lead to a disruption in recognition of tumor cells by the immune cell system, including T lymphocytes and dendritic cells which lead to the development of cervical cancer… More > Graphic Abstract

    The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

  • Open Access

    REVIEW

    Ferroptosis’s Role in Genitourinary System Cancer

    Chaoying Liu1,#, Xinfeng Yang2,#, Ye Wang2,#, Keyu Wu2, Siqiang Li2, Gailing Wang2, Yun Li2, Chuanfeng Li2, Mingcheng Wang2, Enzhong Li2,*

    Oncologie, Vol.24, No.4, pp. 679-691, 2022, DOI:10.32604/oncologie.2022.025705

    Abstract A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new… More >

  • Open Access

    ARTICLE

    Early-Stage Cervical Cancerous Cell Detection from Cervix Images Using YOLOv5

    Md Zahid Hasan Ontor1, Md Mamun Ali1, Kawsar Ahmed2,3,*, Francis M. Bui3, Fahad Ahmed Al-Zahrani4, S. M. Hasan Mahmud5, Sami Azam6

    CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3727-3741, 2023, DOI:10.32604/cmc.2023.032794

    Abstract Cervical Cancer (CC) is a rapidly growing disease among women throughout the world, especially in developed and developing countries. For this many women have died. Fortunately, it is curable if it can be diagnosed and detected at an early stage and taken proper treatment. But the high cost, awareness, highly equipped diagnosis environment, and availability of screening tests is a major barrier to participating in screening or clinical test diagnoses to detect CC at an early stage. To solve this issue, the study focuses on building a deep learning-based automated system to diagnose CC in the early stage using cervix… More >

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