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  • Open Access

    ARTICLE

    RASAL2 acts as a tumor suppressor in cervical cancer cells

    LI CHEN1,2, FANGFANG LI2, SHOUYAN CAO2, XIA LI2, CHAO ZHOU2, SAI HAN1,*, YOUZHONG ZHANG1,*

    BIOCELL, Vol.47, No.7, pp. 1549-1560, 2023, DOI:10.32604/biocell.2023.027308

    Abstract Background: This study was designed to investigate the roles of RASAL2 in cervical cancer (CC). Methods: Fifty-four CC tissues and 33 adjacent tissues were obtained from CC patients admitted to our hospital between March 2012 and June 2014. Real-time polymerase chain reaction and western blotting were performed to analyze the expression of RASAL2 mRNA and protein in these tissues, CC cell lines, and normal cervical cells. Over-expression and silencing of RASAL2 were induced after transfection, and the migration, invasion, and proliferation of the CC cell lines were examined. Results: RASAL2 mRNA and protein expressions were significantly down-regulated More >

  • Open Access

    ARTICLE

    Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction

    YUTING WANG1,2,3, PEIWEN FAN1,2,3, YANING FENG1,2,3, XUAN YAO4, YANCHUN PENG4, RUOZHENG WANG1,2,3,*

    BIOCELL, Vol.47, No.6, pp. 1365-1375, 2023, DOI:10.32604/biocell.2023.027201

    Abstract Background: This study was designed to investigate the feasibility of tumor-infiltrating immune cells with different phenotypic characteristics for predicting short-term clinical responses in patients with locally advanced cervical cancer (LACC). Methods: Thirty-four patients who received concurrent chemoradiotherapy and twenty-one patients who merely underwent radiotherapy were enrolled in this study. We retrospectively analyzed the T cell markers (i.e., CD3, CD4, CD8), memory markers (i.e., CD45, CCR7), and differentiation markers (i.e., CD27) in the peripheral blood and tumor tissues of patients with LACC before treatment based on flow cytometry. We also analyzed the relationship of T cell subsets… More >

  • Open Access

    ARTICLE

    Raloxifene-loaded and aptamer-bonded exosomes induce autophagic and apoptotic death in HeLa cells by enhancing the lysosomotropic effect

    OMER ERDOGAN1, GULEN MELIKE DEMIRBOLAT2, OZGE CEVIK1,*

    BIOCELL, Vol.47, No.5, pp. 1051-1063, 2023, DOI:10.32604/biocell.2023.028129

    Abstract Background: Raloxifene, a selective estrogen receptor modulator, is also known to be a lysosomotropic agent. The bioavailability of raloxifene is around 2% due to extensive hepatic transport. Exosomes are nanosized vesicles that are naturally released from cells. Method: In this study, exosomes released from HeLa cervical cancer cells were loaded with raloxifene to increase its bioavailability, and an aptamer was attached to the exosome membrane for targeting only HeLa cells. Characterization of exosomes isolated from HeLa cells was performed by transmission electron microscopy, zeta sizer, and western blotting. In addition, the cytotoxic, apoptotic, autophagic, and lysosomotropic More >

  • Open Access

    ARTICLE

    Early-Stage Cervical Cancerous Cell Detection from Cervix Images Using YOLOv5

    Md Zahid Hasan Ontor1, Md Mamun Ali1, Kawsar Ahmed2,3,*, Francis M. Bui3, Fahad Ahmed Al-Zahrani4, S. M. Hasan Mahmud5, Sami Azam6

    CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3727-3741, 2023, DOI:10.32604/cmc.2023.032794

    Abstract Cervical Cancer (CC) is a rapidly growing disease among women throughout the world, especially in developed and developing countries. For this many women have died. Fortunately, it is curable if it can be diagnosed and detected at an early stage and taken proper treatment. But the high cost, awareness, highly equipped diagnosis environment, and availability of screening tests is a major barrier to participating in screening or clinical test diagnoses to detect CC at an early stage. To solve this issue, the study focuses on building a deep learning-based automated system to diagnose CC in… More >

  • Open Access

    ARTICLE

    Pre Screening of Cervical Cancer Through Gradient Boosting Ensemble Learning Method

    S. Priya1,*, N. K. Karthikeyan1, D. Palanikkumar2

    Intelligent Automation & Soft Computing, Vol.35, No.3, pp. 2673-2685, 2023, DOI:10.32604/iasc.2023.028599

    Abstract In recent years, cervical cancer is one of the most common diseases which occur in any woman regardless of any age. This is the deadliest disease since there were no symptoms shown till it is diagnosed to be the last stage. For women at a certain age, it is better to have a proper screening for cervical cancer. In most underdeveloped nations, it is very difficult to have frequent scanning for cervical cancer. Data Mining and machine learning methodologies help widely in finding the important causes for cervical cancer. The proposed work describes a multi-class More >

  • Open Access

    ARTICLE

    Cervical Cancer Detection Based on Novel Decision Tree Approach

    S. R. Sylaja Vallee Narayan1,*, R. Jemila Rose2

    Computer Systems Science and Engineering, Vol.44, No.2, pp. 1025-1038, 2023, DOI:10.32604/csse.2023.022564

    Abstract Cervical cancer is a disease that develops in the cervix’s tissue. Cervical cancer mortality is being reduced due to the growth of screening programmers. Cervical cancer screening is a big issue because the majority of cervical cancer screening treatments are invasive. Hence, there is apprehension about standard screening procedures, as well as the time it takes to learn the results. There are different methods for detecting problems in the cervix using Pap (Papanicolaou-stained) test, colposcopy, Computed Tomography (CT), Magnetic Resonance Image (MRI) and ultrasound. To obtain a clear sketch of the infected regions, using a… More >

  • Open Access

    ARTICLE

    Green Synthesis of Reduced Graphene Oxide Nanosheet by using L-ascorbic Acid and Study of its Cytotoxicity on Human Cervical Cancer Cell Line

    PRABHAT KUMAR, ANJANA SARKAR, PURNIMA JAIN*

    Journal of Polymer Materials, Vol.39, No.1-2, pp. 121-135, 2022, DOI:10.32381/JPM.2022.39.1-2.8

    Abstract Biocompatible graphene derivative materials (GBMs) to harness the maximum potential of pristine graphene biologically, is the most important strategy for its advanced applications in pharmaceutical and other biomedical fields. Currently, scientists are trying to find this by using biopolymer nanocomposites or anchored materials. Nevertheless, tuning the bare GBMs towards biocompatibility is a beautiful approach to exploit the fundamental potential of pristine graphene vis-à-vis suppressing the effects of incorporated biopolymers or anchored materials. Herein, a large-scale, cost-effective, facile, and environment-friendly green synthetic strategy is used for the synthesis of reduced graphene oxide (rGO) nanosheet using L-ascorbic… More >

  • Open Access

    REVIEW

    The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

    PARISA SHIRI AGHBASH1,2,4, NIMA HEMMAT1, BEHZAD BARADARAN1,3, AHAD MOKHTARZADEH1, VAHDAT POORTAHMASEBI2,4, MAHIN AHANGAR OSKUEE2,4, HOSSEIN BANNAZADEH BAGHI1,2,4,*

    Oncology Research, Vol.30, No.3, pp. 99-116, 2022, DOI:10.32604/or.2022.026776

    Abstract Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. The signaling pathways involved in the transformation of normal cells to cancerous form and the subsequently expressed programmed cell death-ligand 1 (PD-L1) on the surface of the transformed cells lead to a disruption in recognition of tumor cells by the immune cell system, including T lymphocytes and dendritic cells which lead to… More > Graphic Abstract

    The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

  • Open Access

    REVIEW

    Ferroptosis’s Role in Genitourinary System Cancer

    Chaoying Liu1,#, Xinfeng Yang2,#, Ye Wang2,#, Keyu Wu2, Siqiang Li2, Gailing Wang2, Yun Li2, Chuanfeng Li2, Mingcheng Wang2, Enzhong Li2,*

    Oncologie, Vol.24, No.4, pp. 679-691, 2022, DOI:10.32604/oncologie.2022.025705

    Abstract A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of More >

  • Open Access

    ARTICLE

    Serum Level of Tumor-Specific Growth Factor in Patients with Cervical Cancer and Its Potential Prognostic Role

    Yao Wu1,2,#, Bin Qu1,#, Haoming Shen1, Hongyu Deng1, Faqin Tang1,*

    Oncologie, Vol.24, No.3, pp. 499-512, 2022, DOI:10.32604/oncologie.2022.024951

    Abstract Background: Tumor-specific growth factor (TSGF) is associated with invasion and metastasis of various malignancies and adverse clinical outcomes. TSGF is also highly expressed in cervical cancer (CC), but its clinical value is unclear. Materials and Methods: Serum samples from malignancies, including CC, non-Hodgkin’s lymphoma (NHL), nasopharyngeal carcinoma (NPC), colorectal cancer (CRC), lung cancer (LCA), ovarian cancer (OC), breast cancer (BC), gastric carcinoma (GC), and pancreatic cancer (PC) were collected, and TSGF was detected using a chemiluminescence assay. The patients with CC were followed-up over five years, and their clinicopathological parameters were analyzed. Meanwhile, the pre- and post-treatment… More >

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