Attilio Barretta1,2,*, Angelo Mottaran1, Nicolas Carl2, Francesco Prata2,3, Sara Tamburini1,2, Edoardo Beatrici2, Mario De Angelis2,4, Francesco Cei2,4, Natali Rodriguez Peñaranda2, Francesco Pepillo2, Alessio Guidotti2, Vincenzo Cavarra2, Claudio Brancelli2, Pietro Pasquini2, Pietro Piazza1, Cristian Vincenzo Pultrone1, Hussam Dababneh1, Lorenzo Bianchi1, Alessandro Larcher4, Alexandre Mottrie2, Rocco Papalia3, Riccardo Schiavina1
Canadian Journal of Urology, Vol.33, No.4, pp. 783-793, 2026, DOI:10.32604/cju.2026.078354
- 21 August 2026
Abstract Objectives: Complex cystic renal lesions pose a significant diagnostic challenge in the preoperative assessment of malignancy. Although percutaneous renal mass biopsy is well established for solid tumours diagnosis, its role in cystic lesions remains controversial. This systematic review aims to evaluate the diagnostic performance, safety, and clinical impact of percutaneous sampling—fine-needle aspiration (FNA) and core needle biopsy (CNB)—in Bosniak III–IV renal cysts. Methods: A systematic review and meta-analysis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [International Prospective Register of Systematic Reviews (PROSPERO) ID CRD420251124563]. PubMed/MEDLINE (Medical Literature… More >