Kai Zhang^*, Huajun Chen^†, Ye Wang^‡, Lin Yang^§, Chengzhi Zhou^¶, Weiqiang Yin^#, Guangsuo Wang^§, Xinru Mao^**, Jianxing Xiang^**, Bing Li^**, Tengfei Zhang^**, Shihong Fei^*

Oncology Research, Vol.27, No.5, pp. 575-582, 2019, DOI:10.3727/096504018X15344979253618

Abstract RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features, and therapeutic options in RET-rearranged patients remain unclear, especially in Chinese lung cancer patients. We retrospectively collected 6,125 Chinese lung cancer patients who have been profiled using next-generation sequencing (NGS). The clinical demographics and molecular features of RET rearrangement-positive patients were analyzed. RET rearrangements were identified in 84 patients with a proportion of 1.4% in our cohort. The median age at diagnosis was 58 years, and it mainly occurred in females with adenocarcinoma histology. KIF5B-RET was the most frequent… More >

Phong Teck Lee, Felix Maverick Uy, Jie Sheng Foo, Ju Le Tan

Congenital Heart Disease, Vol.13, No.6, pp. 1005-1011, 2018, DOI:10.1111/chd.12667

Abstract Background: Ventricular septal defect (VSD) is one of the most common congenital heart anomalies in childhood and there is an increasing prevalence of VSDs in the adult population. The long‐term risk of infective endocarditis (IE) is of concern. The aim of this study was to clarify and compare the incidence of IE in adults with re‐ paired and unrepaired VSDs.
Methods: Patients with VSDs were identified using the Adult Congenital Heart Disease registry at the National Heart Centre Singapore. Patients were divided into Group 1 (repaired VSD) and Group 2 (unrepaired VSDs). The electronic medical re‐ cords were searched for… More >

Kieu T. Huynh¹, Vien T. Truong^2,3, Tam N. M. Ngo^3,4, Thao B. Dang⁵, Wojciech Mazur³, Eugene S. Chung^3,6, Justin T. Tretter⁷, Dean J. Kereiakes³, Tuyen K. Le⁸, Vinh N. Pham¹

Congenital Heart Disease, Vol.14, No.5, pp. 772-777, 2019, DOI:10.1111/chd.12781

Abstract Objectives: The aim of our work is to investigate the clinical characteristics of coro‐ nary artery fistula (CAF) anomalies in South Vietnam.
Methods: This is a retrospective analysis of 119 patients with diagnosis of definite CAF between January 1992 and April 2016. The demographic, clinical, echocardio‐ graphic, and angiographic characteristics and management of CAF with short‐term outcomes are described.
Results: The median age was 15 years (range, 1‐79 years), with 49 male (41%) and 70 female (59%). There were 77 symptomatic patients (64.7%) and 91 patients (76.5%) who presented with a murmur. The electrocardiogram was abnormal in 45.4% and cardiac… More >