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  • Open Access

    ARTICLE

    The impact of paralog genes: detection of copy number variation in spinal muscle atrophy patients

    Sergio LAURITO1, 2, Juan A. CUETO1, 3, Jimena PEREZ1, María ROQUÉ1, 2

    BIOCELL, Vol.42, No.3, pp. 87-92, 2018, DOI:10.32604/biocell.2018.07016

    Abstract Spinal muscular atrophy (SMA) is caused by dysfunction of the alpha motor neurons of the spinal cord. It is an autosomal recessive disease associated to the SMN1 gene, located in the subtelomeric region of 5q13. A paralog SMN2 gene is located at the centromeric region of the same chromosome, which apparently originated by an ancestral inverted duplication occurring only in humans. The exon sequence differs in two nucleotides in exon 7 and exon 8, which leads to an SMN2 transcript that lacks exon 7 and results in a truncated protein. Part (10%) of the SMN2 transcripts avoids the splicing of… More >

  • Open Access

    ARTICLE

    Trace Elements in the Soil-Plant Systems of Copper Mine Areas-A Case Study From Murgul Copper Mine From the Black Sea Region of Turkey

    Munir Ozturk1,*, Volkan Altay2, Mahir Kucuk3, Ibrahim Ertuğrul Yalçın4

    Phyton-International Journal of Experimental Botany, Vol.88, No.3, pp. 223-238, 2019, DOI:10.32604/phyton.2019.07446

    Abstract This study presents a case study on the heavy metal analysis of soil and plant samples around the Murgul copper mine, one of the first and most important mining areas in Turkey. An attempt has been made to investigate the status of trace elements like Al3+, Fe2+, Cu2+, Zn2+, Pb2+, Ni2+, Co2+ and Cd2+ in soils and plants. The sampling localities were taken from 500 m, 600 m, and 1000 m altitudes around the factory and at 1400 m in the forest zone. The aboveground parts and foliage ash of Silene compacta, Tussilago farfara, Smilax excelsa, Rhododendron ponticum, R. luteum,… More >

  • Open Access

    ABSTRACT

    Molecular dynamics simulations of the nano-indentation for aluminum and copper

    Xiaozhi Tang, Yafang Guo, Yu Gao

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.20, No.1, pp. 25-26, 2011, DOI:10.3970/icces.2011.020.025

    Abstract Atomistic simulations were performed to study the nano-indentation for two kinds of FCC metals, aluminum and copper. Two different deformation mechanisms were observed in our simulation under exactly the same simulation condition. An embedded atom method potential was employed for copper and a generalized form of EAM potential due to Finnis and Sinclair for aluminum. In the simulation model, the substrate was constructed with 78408 atoms in an 8I?*40I?*60I? cell, here I? means the lattice constant. The indenter was modeled by a cubic with its side length of 8a.During the simulation, the period boundary condition was applied to the (1… More >

  • Open Access

    ABSTRACT

    Study on IDEAL Algorithm for Macroscopic Model of Fluid Flow and Heat Transfer in Porous Media

    Shangmin Ao, Peng Wang*, Lin Zhang, Yajun Deng, Dongliang Sun*, Bo Yu

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.3, pp. 152-153, 2019, DOI:10.32604/icces.2019.05005

    Abstract The problem of fluid flow and heat transfer in porous media is one common phenomenon in industrial production and daily life. Numerical simulation for the above problem can provide a realistic understanding of transport processes and thus can help to optimize energy consumption. However, in the macroscopic model of fluid flow and heat transfer, the convergence rate of traditional numerical methods is usually poor as the hygroscopic properties of porous media. Therefore, it is of great significance to develop an efficient algorithm for the macroscopic model of fluid flow and heat transfer in porous media. The IDEAL (Inner Doubly-iterative Efficient… More >

  • Open Access

    ABSTRACT

    In Situ Microscopic Observation and Crystal Plasticity Simulation of Fatigue Crack Formation in Ti-6Al-4V Alloy

    Fabien Briffod*, Alexandre Bleuset, Takayuki Shiraiwa, Manabu Enoki

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.2, pp. 125-125, 2019, DOI:10.32604/icces.2019.05319

    Abstract The fatigue behavior of metallic materials is a multi-scale problem (from a time and length-scale perspective) intimately influenced by microstructural features that determine the early stages of crack propagation. Prediction of fatigue life is traditionally based on the evaluation of macroscopic mechanical fields at the structure level and on the application of empirical rules. However, these structure-oriented methods are material-specific and do not consider the material variability at lower scales. Hence, reliable prediction of fatigue performances and its variability requires on one side the characterization and quantification of early damage mechanisms and on the other side the incorporation of local… More >

  • Open Access

    ABSTRACT

    Microscopic Model Containing Micro-Voids for Analysis of Cement Mortar Damage Fracture Process

    Jichang Wang, Xiaoming Guo*, Xiaoxiao Sun

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.21, No.4, pp. 79-79, 2019, DOI:10.32604/icces.2019.05248

    Abstract Cement mortar is an important component of many composite materials and one of the most widely used materials in engineering construction. At microscopic level, cement mortar can be regarded as a multiphase material composed of fine aggregates, cement paste, and a great many of initial defects, the form of which are micro-cracks and micro-voids. The macroscopic properties of cement mortar will be influenced by mechanical properties of different constituents and complex internal structures. The microscopic model containing micro-voids is established by the method of secondary development. The process of cement mortar damage fracture is studied. The fracture toughness of fine… More >

  • Open Access

    ABSTRACT

    Parallelized Microscopic Traffic Simulation with Dynamic Load Balancing

    Hideki Fujii*, Yuta Ushimaru, Tomonori Yamada, Shinobu Yoshimura

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.21, No.3, pp. 63-63, 2019, DOI:10.32604/icces.2019.05442

    Abstract In order to evaluate transportation policies quantitatively, virtual social experiments using traffic simulators are adequate. In particular, simulators with features of both precision and scalability are preferable for applications to real-world and wide-spread traffic phenomena. In this research, we tried to parallelize a multi-agent-based traffic simulator (ADVENTURE_Mates) and enhance its parallelization performance. In the simulator, a road map is modeled as a graph and cars are modeled as autonomous agents. A car agent acquires information from its circumference (other cars, traffic lights, etc.), makes a decision autonomously, and acts based on the decision. The precision is accomplished by employing a… More >

  • Open Access

    ABSTRACT

    Kinetics of Order-order transitions in block copolymers: Cylinders to spheres

    Rama Bansil1, Minghai Li1, Yongsheng Liu1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.4, pp. 75-76, 2009, DOI:10.3970/icces.2009.013.075

    Abstract Block copolymers are known to form micelles of different shapes in selective solvents that preferentially dissolve one of the constituent blocks. These micellar fluids exhibit various ordered and disordered phases. To gain microscopic insight into the mechanisms involved in the transformation between different phases we use synchrotron-based time-resolved small angle x-ray scattering (SAXS) and coarse-grained discrete Brownian Dynamics simulations. In this talk I will focus on the kinetics of the transformation from the hexagonal packed cylinder (HEX) phase to cubic phases (FCC or BCC). SAXS data was interpreted with a geometrical model for the transformation from cylinders to spheres. Brownian… More >

  • Open Access

    ABSTRACT

    Arrangement of Monomer Injection in the Characteristics of Copolymer

    Mohsen Ghorbani1, Hossein Eisazadeh2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.4, pp. 67-68, 2009, DOI:10.3970/icces.2009.013.067

    Abstract Polypyrrole/Poly(vinyl acetate) (PPy/PVAc) copolymer was prepared by the copolymerization of vinyl acetate and pyrrole using FeCl3 and benzoylperoxide as an oxidant in the presence of various surfactants such as sodium dodecylbenzenesulfonate and poly (ethylene glycol) in the aqueous/non-aqueous media. The PPy/PVAc copolymer was characterized in terms of conductivity, morphology, chemical structure, particle size and yield. The results indicate that the morphology, particle size, yield and electrical conductivity of the products are dependent on the type of surfactant and the arrangement of monomer injection. The chemical structure of obtained product was determined by FTIR spectroscopy. By comparison FTIR spectra between pure… More >

  • Open Access

    ABSTRACT

    A Lattice Boltzmann Method for modeling the oscillation of Min proteins: Oscillation pattern due to the initial copy of MinD and MinE

    Somchai Sriyab1, Wannapong Triampo2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.3, pp. 51-52, 2009, DOI:10.3970/icces.2009.013.051

    Abstract Understanding of Bacteria cell division is essential for an understanding of microorganism as well as the origin of the life. Particularly, in cell division process of \emph {E. coli}, Min proteins (MinD and MinE) play crucial roles to regulate the dividing dynamics physically via their oscillatory dynamics from pole to pole. In this work, we have developed a numerical scheme based on the mesoscopic Lattice Boltzmann Method (LBM) to simulate the coarse-grained coupled reaction-diffusion equations model used to describe the MinD/MinE interaction in two dimensions. Biologically, we have focused on investigating how the protein copies affect the oscillation patterns as… More >

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