Shu-Chuan Chu¹, Xiaomeng Yang¹, Li Zhang², Václav Snášel³, Jeng-Shyang Pan^1,4,*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3763-3786, 2024, DOI:10.32604/cmc.2024.048594

Abstract The Gannet Optimization Algorithm (GOA) and the Whale Optimization Algorithm (WOA) demonstrate strong performance; however, there remains room for improvement in convergence and practical applications. This study introduces a hybrid optimization algorithm, named the adaptive inertia weight whale optimization algorithm and gannet optimization algorithm (AIWGOA), which addresses challenges in enhancing handwritten documents. The hybrid strategy integrates the strengths of both algorithms, significantly enhancing their capabilities, whereas the adaptive parameter strategy mitigates the need for manual parameter setting. By amalgamating the hybrid strategy and parameter-adaptive approach, the Gannet Optimization Algorithm was refined to yield the AIWGOA. Through a performance analysis of… More >

JIANYUN XIE^1,*, LINJIE LU¹, JIALI ZHANG¹, QIRUI LI², WEIDONG CHEN^1,*

Oncology Research, Vol.32, No.3, pp. 529-544, 2024, DOI:10.32604/or.2023.031511

Abstract Objective: Circular ribose nucleic acids (circRNAs) are implicated in tumor progression and drug resistance of prostate cancer (PCa). The current work explored the function of circ_0005203 (circTHSD4) in the malignancy and docetaxel (DTX) resistance of PCa. Methods: circTHSD4 expression within PCa as well as matched non-carcinoma samples was measured through real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a subcellular fraction assay was conducted to determine circTHSD4 subcellular localization within PCa cells. In addition, we performed a Western blot (WB) assay to detect high-mobility-group A2 protein (HMGA2) levels. Besides, functional associations of two molecules were investigated through dual luciferase… More >

Yi Zhang^*, Jiamin Guo, Huanghua Peng

Energy Engineering, Vol.120, No.11, pp. 2489-2502, 2023, DOI:10.32604/ee.2023.029496

Abstract The windy environment is the main cause affecting the efficiency of offshore wind turbine installation. In order to improve the stability and efficiency of single-blade installation of offshore wind turbines under high wind speed conditions, the Stewart platform is used as an auxiliary tool to help dock the wind turbine blade in this paper. In order to verify the effectiveness of the Stewart platform for blade docking, a blade docking simulation system consisting of the Stewart platform, wind turbine blade, and wind load calculation module was built based on Simulink/Simscape Multibody. At the same time, the PID algorithm is used… More >

WEI LU^1,*, KAN GUO², DIANMEI XI¹, ZHAOXIA XIA¹

BIOCELL, Vol.47, No.9, pp. 1995-2008, 2023, DOI:10.32604/biocell.2023.024591

Abstract Background: Mesenchymal stem cell (MSC)-derived exosomes are closely related to pyroptosis in diabetic nephropathy (DN). This study aimed to explore the protective effect of exosomal miR-30a-5p on podocyte pyroptosis in DN. Methods: Streptozotocin was used to establish the mouse model of DN. Human bone marrow MSC-derived exosomes were extracted and identified via transmission electron microscopy, nanoparticle tracking analysis, and western blotting. MiR-30a-5p mimics and non-control (NC) mimics were transfected into MSCs and podocytes, and exosomes were isolated from the MSCs. High glucose (HG)-induced podocyte model was established to determine the effect of exosomal miR-30a-5p on pyroptosis and inflammation in vitro.… More >

SHIMING YE^1,2,#, YUFENG ZHANG^3,#, TING LIU⁴, CONG WANG³, ZHENG YAN⁵, WANDONG SHE^2,*, HAIBING HUA^4,*

BIOCELL, Vol.47, No.9, pp. 1947-1964, 2023, DOI:10.32604/biocell.2023.029333

Abstract Background: Despite its widespread therapeutic use and effectiveness, the underlying pharmacologic mechanisms of Wendan decoction (WDD) and how it works to treat sudden deafness (SD) remain unclear. In this study, the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and molecular docking. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to identify the active compounds and target genes of WDD, and genes associated with SD were screened on five databases. RGUI conducted Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A compound-target network was… More >

FENGMEI QIAN^1,2, PEIYAO REN², LI ZHAO², DANNA ZHENG², WENFANG HE³, JUAN JIN^3,*

BIOCELL, Vol.47, No.8, pp. 1853-1867, 2023, DOI:10.32604/biocell.2023.029353

Abstract Background: Diabetic nephropathy (DN) is a serious complication of diabetes with rising prevalence worldwide. We aimed to explore the anti-DN mechanisms of the compound celastrol derived from the medicinal plant Tripterygium wilfordii. Methods: Celastrol-related targets were obtained from Herbal Ingredients’ Targets (HIT) and GeneCards databases. DN-related targets were retrieved from GeneCards, DisGeNET, and Therapeutic Targets Database (TTD). A Protein-protein interaction (PPI) network was established using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using ClusterProfiler. The cytoHubba plugin was used to select… More > Graphic Abstract

Siyu Lu¹, Ligao Cai¹, Zhixin Liu², Shan Liu¹, Bo Yang¹, Lirong Yin³, Mingzhe Liu⁴, Wenfeng Zheng^1,*

Computer Systems Science and Engineering, Vol.47, No.2, pp. 1881-1899, 2023, DOI:10.32604/csse.2023.034853

Abstract With the development of Internet technology, the explosive growth of Internet information presentation has led to difficulty in filtering effective information. Finding a model with high accuracy for text classification has become a critical problem to be solved by text filtering, especially for Chinese texts. This paper selected the manually calibrated Douban movie website comment data for research. First, a text filtering model based on the BP neural network has been built; Second, based on the Term Frequency-Inverse Document Frequency (TF-IDF) vector space model and the doc2vec method, the text word frequency vector and the text semantic vector were obtained… More >

SEUNGHYUN AHN¹, JUNG-YEON LEE¹, JIHA SUNG^1,2, HYUN JOO KIM³, SEYEON PARK^1,2,*

BIOCELL, Vol.47, No.7, pp. 1661-1673, 2023, DOI:10.32604/biocell.2023.027984

Abstract Background: Although the GABAA receptor (GABAAR) has been proposed as the main action site for sevoflurane, isoflurane, halothane, enflurane, propofol, and benzodiazepines (BZDs), binding of these anesthetics with high-resolution structures of the GABAAR have been rarely examined by comparative docking analyses. Moreover, various combinations of ligands on more GABAARs with various subtypes need to be analyzed to understand the elaborate action mechanism of GABAARs better because some GABAA ligands showed specificity toward the distinct subtypes of the GABAAR. Methods: We performed in silico docking analysis to compare the binding modes of sevoflurane, isoflurane, halothane, enflurane, propofol, and BZDs to the… More >

QIAO ZHOU^2,3,4, JIAN LIU^1,2,*, LING XIN¹, YANYAN FANG^1,2, LEI WAN^1,2, DAN HUANG^1,2, JIANTING WEN^1,2

BIOCELL, Vol.47, No.7, pp. 1623-1643, 2023, DOI:10.32604/biocell.2023.028331

Abstract Objective: On the basis of data mining, systematic pharmacology, molecular docking, and experiment validation, the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis (OA) were explored. Methods: The association rule analysis was effectively applied to highlight the correlation between Coicis Semen and oxidative inflammation indices. The random walk model was subsequently used to evaluate the clinical efficacy of Coicis Semen. Network pharmacology was used to predict network targets. The binding affinity of the active ingredient in Coicis Semen to the key target of OA was also successfully predicted. Results: Coicis Semen showed a significant reduction in oxidative-inflammatory… More >

Yuhang Chen¹, Mahdi Bahaghighat^2,*, Aghil Esmaeili Kelishomi³, Jingyi Du^1,*

Computer Systems Science and Engineering, Vol.47, No.1, pp. 675-697, 2023, DOI:10.32604/csse.2023.038234

Abstract In the digital world, a wide range of handwritten and printed documents should be converted to digital format using a variety of tools, including mobile phones and scanners. Unfortunately, this is not an optimal procedure, and the entire document image might be degraded. Imperfect conversion effects due to noise, motion blur, and skew distortion can lead to significant impact on the accuracy and effectiveness of document image segmentation and analysis in Optical Character Recognition (OCR) systems. In Document Image Analysis Systems (DIAS), skew estimation of images is a crucial step. In this paper, a novel, fast, and reliable skew detection… More >