DER-JEU CHEN, CHENG-HUNG LAI^*

BIOCELL, Vol.47, No.6, pp. 1317-1327, 2023, DOI:10.32604/biocell.2023.028883

Abstract Background: Magnolol, a bioactive extract of the Chinese herb Magnolia officinalis has a protective effect against periodontitis. This study is aimed to explore the mechanisms involved in the functioning of magnolol against periodontitis and provide a basis for further research. Methods: Network pharmacology analysis was performed based on the identification of related targets from public databases. The Protein-protein interaction (PPI) network was constructed to visualize the significance between the targets of magnolol and periodontitis. Subsequently, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to predict the functions and the signal regulatory pathways involved in… More >

MAN REN^1,2,3,#, YUAN YANG^1,2,#, DAN LI⁴, NANNAN ZHAO⁵, YUPING WANG^2,6,*, YONGNING ZHOU^2,6,*

BIOCELL, Vol.47, No.5, pp. 977-989, 2023, DOI:10.32604/biocell.2023.028402

Abstract Background: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer activity. Methods: In this study, the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular docking. First, the targets of PGG were searched in the Herbal Ingredients’ Targets (HIT), Similarity Ensemble Approach (SEA), and Super-PRED databases. The potential targets related to gastric cancer were predicted from the Human Gene Database (GeneCards) and DisGeNET databases. The intersecting targets of PGG and gastric cancer were obtained by Venn diagram and then subjected to protein-protein interaction analysis to screen hub targets. Functional and… More >

MIZUNA YANO¹, KOTA HIROI¹, TETSUYA YUASA¹, KENJI INOUE¹, OSAMU YAMAMOTO¹, TAKAO NAKAMURA², DAISUKE SATO¹, ZHONGGANG FENG^1,*

BIOCELL, Vol.47, No.5, pp. 1095-1106, 2023, DOI:10.32604/biocell.2023.028186

Abstract Background: Human heart changes its energetic substrates from lactate and glucose to fatty acids during the neonatal period. Noticing the lack of fatty acids in media for the culture of cardiomyocytes derived from human pluripotent stem cells (hiPS-CM), researchers have supplemented mixtures of fatty acids to hiPS-CM and reported the enhancement in the maturation of hiPS-CM. In our previous studies, we separately supplemented two polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) or arachidonic acid (AA), to rat fetal cardiomyocytes and found that the supplementations upregulated the expressions of mRNAs for cardiomyocyte differentiation, fatty acid metabolism, and cellular adhesion. The enhancement… More >

Emad Sami Jaha^*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 2805-2831, 2023, DOI:10.32604/cmc.2023.036169

Abstract A document layout can be more informative than merely a document’s visual and structural appearance. Thus, document layout analysis (DLA) is considered a necessary prerequisite for advanced processing and detailed document image analysis to be further used in several applications and different objectives. This research extends the traditional approaches of DLA and introduces the concept of semantic document layout analysis (SDLA) by proposing a novel framework for semantic layout analysis and characterization of handwritten manuscripts. The proposed SDLA approach enables the derivation of implicit information and semantic characteristics, which can be effectively utilized in dozens of practical applications for various… More >

Byeori Kim¹, Minseong Choi¹, Taek-Young Youn², Jeong Hyun Yi¹, Haehyun Cho^1,*

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 3725-3742, 2023, DOI:10.32604/iasc.2023.036574

Abstract Recently, there has been a sudden shift from using traditional office applications to the collaborative cloud-based office suite such as Microsoft Office 365. Such cloud-based systems allow users to work together on the same document stored in a cloud server at once, by which users can effectively collaborate with each other. However, there are security concerns unsolved in using cloud collaboration. One of the major concerns is the security of data stored in cloud servers, which comes from the fact that data that multiple users are working together cannot be stored in encrypted form because of the dynamic characteristic of… More >

PRIYANKA SOLANKI¹, NISARG RANA¹, PRAKASH C. JHA², ANU MANHAS^1,*

BIOCELL, Vol.47, No.4, pp. 707-729, 2023, DOI:10.32604/biocell.2023.026615

Abstract Cancer is considered one of the most lethal diseases responsible for causing deaths worldwide. Although there have been many breakthroughs in anticancer development, cancer remains the major cause of death globally. In this regard, targeting cancer-causing enzymes is one of the efficient therapeutic strategies. Biological functions like cell cycle, transcription, metabolism, apoptosis, and other depend primarily on cyclin-dependent kinases (CDKs). These enzymes help in the replication of DNA in the normal cell cycle process, and deregulation in the functioning of any CDK can cause abnormal cell growth, which leads to cancer. This review is focused on anticancer drug discovery against… More >

Naseer Ahmed Sajid¹, Munir Ahmad¹, Atta-ur Rahman^2,*, Gohar Zaman³, Mohammed Salih Ahmed⁴, Nehad Ibrahim², Mohammed Imran B. Ahmed⁴, Gomathi Krishnasamy⁶, Reem Alzaher², Mariam Alkharraa², Dania AlKhulaifi², Maryam AlQahtani², Asiya A. Salam⁶, Linah Saraireh⁵, Mohammed Gollapalli⁶, Rashad Ahmed⁷

Computer Systems Science and Engineering, Vol.46, No.2, pp. 2195-2214, 2023, DOI:10.32604/csse.2023.033844

Abstract From the beginning, the process of research and its publication is an ever-growing phenomenon and with the emergence of web technologies, its growth rate is overwhelming. On a rough estimate, more than thirty thousand research journals have been issuing around four million papers annually on average. Search engines, indexing services, and digital libraries have been searching for such publications over the web. Nevertheless, getting the most relevant articles against the user requests is yet a fantasy. It is mainly because the articles are not appropriately indexed based on the hierarchies of granular subject classification. To overcome this issue, researchers are… More >

ASPASIA MANTA¹, SPYRIDON KAZANAS², STEFANOS KARAMAROUDIS³, HELEN GOGAS², DIMITRIOS C. ZIOGAS^2,*

Oncology Research, Vol.30, No.5, pp. 211-219, 2022, DOI:10.32604/or.2022.026913

Abstract Epigenetic mechanisms, such as DNA methylation and histone modifications (e.g., acetylation and deacetylation), are strongly implicated in the carcinogenesis of various malignancies. During transcription, the expression and functionality of coding gene products are altered following the histone acetylation and deacetylation. These processes are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. HDAC inhibitors (HDACis) have been developed as promising therapeutic agents, to limit exposure to traditional and toxic chemotherapies and offer more alternatives for some specific malignant diseases with limited options. Mechanistically, these agents affect many intracellular pathways, including cell cycle arrest, apoptosis and differentiation, and their mechanism… More >

D. Viji^*, S. Revathy

Computer Systems Science and Engineering, Vol.46, No.1, pp. 27-42, 2023, DOI:10.32604/csse.2023.030259

Abstract Cloud storage is essential for managing user data to store and retrieve from the distributed data centre. The storage service is distributed as pay a service for accessing the size to collect the data. Due to the massive amount of data stored in the data centre containing similar information and file structures remaining in multi-copy, duplication leads to increase storage space. The potential deduplication system doesn’t make efficient data reduction because of inaccuracy in finding similar data analysis. It creates a complex nature to increase the storage consumption under cost. To resolve this problem, this paper proposes an efficient storage… More >

Fei Wang¹, Jihyun Ma², Nan Zhao³, Chi Lin^3,*, Haixing Jiang^1,*

Oncologie, Vol.24, No.4, pp. 865-895, 2022, DOI:10.32604/oncologie.2022.025447

Abstract Objective: The characteristics of clinical features and prognoses among patients with different racial backgrounds have not been clearly studied. We thus investigated the clinical characteristics and overall survival (OS) differences among Asian, White, and Black patients with pancreatic neuroendocrine tumors (pNETs). Materials and Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients with pNETs between 1983 and 2015. We performed univariable (UVA) and multivariable logistic regression (MVA) to assess the association between variables and race category. A Kaplan-Meier (KM) plot was used to calculate the OS rates. The Cox proportional hazard regression was used to… More >