TANVI VIJAY GUJARAN^1,#, VIGNESH BALAJI EASWARAN^1,#, RUNALI SANKHE¹, PUGAZHANDHI BAKTHAVATCHALAM^2,3, HERMAN SUNIL DSOUZA⁴, K. SREEDHARA RANGANATH PAI^1,*

Oncology Research, Vol.33, No.2, pp. 381-395, 2025, DOI:10.32604/or.2024.049538 - 16 January 2025

Abstract Background: To date, there is no effective cure for the highly malignant brain tumor glioblastoma (GBM). GBM is the most common, aggressive central nervous system tumor (CNS). It commonly originates in glial cells such as microglia, oligodendroglia, astrocytes, or subpopulations of cancer stem cells (CSCs). Glucose plays an important role in the, which energy metabolism of normal and cancer cells, but cancer cells exhibit an increased demand for glucose is required for their differentiation and proliferation. The main aim of this study is to explore the anti-cancer efficacy of the ketogenic diet against GBM. Also,… More >

HUANGLIN DUAN^1,*, BAISHENG XU^1,#, TIANPENG XIE^2,#

BIOCELL, Vol.48, No.12, pp. 1703-1719, 2024, DOI:10.32604/biocell.2024.054873 - 30 December 2024

Abstract Prostate cancer is one of the most common tumors in urology. Dietary prophylaxis can effectively reduce prostate cancer incidence and progression. A growing body of research has shown that natural food ingredients such as Sulforaphane (SFN) can reduce the incidence of prostate cancer. It has a significant inhibitory effect on the progression from local prostate cancer to more aggressive prostate cancer. This article mainly expounds on the prevention mechanism and research progress of sulforaphane in various ways for prostate cancer and provides a reference for its future clinical application. In this review, ‘SFN’, ‘Prostate Cancer’,… More >

YAN ZHENG^1,2, SIHUI MA^3,4,*, KATSUHIKO SUZUKI⁴, HISANORI KATO³, HUIJUAN JIA^3,*

BIOCELL, Vol.47, No.8, pp. 1897-1906, 2023, DOI:10.32604/biocell.2023.027632 - 28 August 2023

Abstract Mental disorders such as depression and anxiety inflict significant burdens on individuals and society. Commonly prescribed treatments often involve cognitive therapy and medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD and its key metabolite, β-hydroxybutyrate (BHB), have been hypothesized to alleviate mental disorders through anti-inflammatory actions, a crucial pathway in the pathophysiology of depression. This mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental disorders. Both human and animal studies More >

Hongqiong Zhang^1,2,#, Xu Wang^3,#, Zhaojing Qian⁴, Buchun Si^1,4,*, Kai Jin⁵, Tengfei Wang⁵

Journal of Renewable Materials, Vol.11, No.10, pp. 3647-3657, 2023, DOI:10.32604/jrm.2023.028438 - 10 August 2023

Abstract Hydrochar prepared with four typical biowastes, pine wood, food waste, digested sewage sludge, and Chlorella were applied for the promotion of anaerobic digestion. The gas production and substrate composition were analyzed associated with the hydrochar characteristics. The results suggested that Chlorella hydrochar (C-C) showed the highest cumulative yield of methane (approximately 345 mL) with high total organic carbon (TOC) removal efficiency and low volatile fatty acids (VAFs) concentration. Especially, food waste hydrochar (F-C) showed a poor effect on anaerobic digestion and aroused 1.4–1.6 g/L accumulation of VAFs, in which the toxic components may account for More >

Saeed Kazemi Najafi¹, Farhood Najafi², Antonio Pizzi^3,*, Fatemeh Hassani Khorshidi^1,*, Rabi Behrooz¹

Journal of Renewable Materials, Vol.11, No.5, pp. 2171-2189, 2023, DOI:10.32604/jrm.2023.027835 - 13 February 2023

Abstract Polyols are groups of organic compounds which contain carbon and are randomly linked to other atoms, especially carbon-carbon and carbon-hydrogen. These compounds are mainly used as reactants to make other polymers. Among biopolymers, lignin is regarded as the base of a new polymer in polyol construction. The present study aimed to investigate the effects of amine type (diethylenetriamine and ethylenediamine) on the modification of lignin-based polyols, so as to provide an alternative to petroleum polyols and, in turn, increase functional groups and reduce their harm to humans’ health and the environment. To this aim, first,… More > Graphic Abstract

YINGHUI GAO, DENGTAI WEN^*, SHIJIE WANG, JINGFENG WANG

BIOCELL, Vol.47, No.1, pp. 41-49, 2023, DOI:10.32604/biocell.2022.022689 - 26 September 2022

Abstract Presenilin (Psn) protein is associated with organismal aging. Mutations in the Psn gene may lead to Alzheimer’s disease (AD), dilated cardiomyopathy (DCM), and many age-dependent degenerative diseases. These diseases seriously affect the quality of life and longevity of the population and place a huge burden on health care and economic systems around the world. Humans have two types of Psn, presenilin-1 (PSEN1) and presenilin-2 (PSEN2). Mutations in the genes encoding PSEN1, PSEN2, and amyloid precursor protein (APP) have been identified as the major genetic causes of AD. Psn is a complex gene strongly influenced by genetic and… More >

S. Raguvaran^1,*, S. Anandamurugan², A. M. J. Md. Zubair Rahman³

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2171-2187, 2023, DOI:10.32604/iasc.2023.028605 - 19 July 2022

Abstract A customized nutrition-rich diet plan is of utmost importance for cancer patients to intake healthy and nutritious foods that help them to be strong enough to maintain their body weight and body tissues. Consuming nutrition-rich diet foods will prevent them from the side effects caused before and after treatment thereby minimizing it. This work is proposed here to provide them with an effective diet assessment plan using deep learning-based automated medical diet system. Hence, an Enhanced Long-Short Term Memory (E-LSTM) has been proposed in this paper, especially for cancer patients. This proposed method will be… More >

TIANTIAN ZHOU^1,3,#, YUMEI ZHANG^1,2,#, JUAN ZHANG^1,2, CHUNYAN XIE², ZHENYA ZHAI^1,2, XIN WU^1,2,3,*

BIOCELL, Vol.46, No.11, pp. 2433-2442, 2022, DOI:10.32604/biocell.2022.021290 - 07 July 2022

Abstract High-fat diet (HFD) is demonstrated to disturb the bile acid metabolism. The rhythm of bile acid metabolism can also be affected by uridine, whose metabolism exhibits a daily rhythm. However, the mechanism of dynamic uridine administration affecting bile acid during HFD remains unclear. In this study, C57BL/6J mice were fed HFD (the control group; CON) or HFD with oral administration of uridine in the daytime (DUR) and nighttime (NUR) to investigate the mechanism of the effect of uridine on the bile acid. This study showed that the mRNA expression of uridine transporters and circadian clock… More >

Nadia Tabassum¹, Abdul Rehman², Muhammad Hamid^3,*, Muhammad Saleem⁴, Saadia Malik⁵, Tahir Alyas²

Intelligent Automation & Soft Computing, Vol.30, No.1, pp. 319-335, 2021, DOI:10.32604/iasc.2021.018870 - 26 July 2021

Abstract Diabetes is one of the ever-increasing menace crippling millions of people worldwide. It is an independent risk factor for many cardiovascular diseases including medium and small vessels and results in heart attack, stroke, kidney failure, blindness, and lower-limb amputations. According to a World Health Organization (WHO) report estimated 1.6 million deaths were the direct result of diabetes. Nutrition plays a vital role in diabetes management alongside physical activity, drugs, and insulin. Weight management can help to avert or delay at pre-diabetic stages. This research work explains the features of the Nutrition Diet Expert System (NDES),… More >

Dheeraj Kumar Sharma¹, Ahsas Goyal^2,*, Shashank Chaturvedi^2,*

Oncologie, Vol.22, No.4, pp. 213-224, 2020, DOI:10.32604/oncologie.2020.014926

Abstract Cancer results due to an imbalance between regulation of cell proliferation and apoptosis. As per the latest data released by World Health Organization (WHO), a large part of global population cannot access proper anticancer therapy, and this imposes a burden of approximately US$ 1.16 trillion on global economy. Relevant studies were identified through electronic searches of Pubmed, Medline, Scopus, Google scholar. In this review, we found that there is extensive range of dietary items whose components can influence either cell proliferation rate or cell death rate or both. Exclusion and avoidance of several dietary items/habits More >