Matthias Schneider^*, Miriam Moser, Varius Dannenberg, Andreas Mangold, Robert Schönbauer, Christian Hengstenberg, Harald Gabriel

Congenital Heart Disease, Vol.15, No.1, pp. 51-58, 2020, DOI:10.32604/CHD.2020.011712

Abstract Background: Predicting the probability for sudden cardiac death (SCD) and thus evaluation of patients for electrical device therapy and/or ablation is one of the main tasks in clinics for adults with congenital heart disease (ACHD) following repaired tetralogy of Fallot (rTOF) patients. Previous data suggests that QRS complex analysis can help identifying those patients who subsequently suffer from SCD. We hypothesized that a long QRS duration is associated with adverse rhythm events if caused by conduction abnormalities but not if caused by right ventricular remodeling. Methods: A retrospective analysis was performed entailing all rTOF patients who were seen at our… More >

Omar Meziab, Dominic J. Abrams, Mark E. Alexander, Laura Bevilacqua, Vassilios Bezzerides, Doug Y. Mah, Edward P. Walsh, John K. Triedman

Congenital Heart Disease, Vol.13, No.3, pp. 419-427, 2018, DOI:10.1111/chd.12589

Abstract Objective: This study evaluates the ability of experienced pediatric electrophysiologists (EPs) to reliably classify incomplete right bundle branch block (IRBBB) and assesses its clinical utility as an isolated ECG finding in a group of healthy outpatient children without prior cardiac evaluation.
Design: We performed a retrospective analysis of all electrocardiographic and echocardiographic records at Boston Children’s Hospital between January 1, 2005, and December 31, 2014. Echocardiographic diagnoses were identified if registered between the date of the index electrocardiogram and the ensuing year. A selected subset of 473 ECGs was subsequently reanalyzed in a blinded manner by six pediatric EPs to… More >

Jun Oyamada¹, Chisato Shimizu¹, Jihoon Kim², Matthew R. Williams^1,3, Eileen Png⁴, Martin L. Hibberd⁴, Adriana H. Tremoulet^1,3, James C. Perry^1,3, Jane C. Burns^1,3

Congenital Heart Disease, Vol.14, No.2, pp. 213-220, 2019, DOI:10.1111/chd.12696

Abstract Background: We previously described the association of genetic variants in calcium channel genes and susceptibility to Kawasaki disease (KD), an acute, self‐limited vas‐ culitis, and the most common cause of acquired cardiac disease in children. Abnormal repolarization of cardiomyocytes and changes in T wave morphology have been re‐ ported in KD but have not been studied systematically.
Methods: We analyzed acute and convalescent ECG T wave morphology in two inde‐ pendent cohorts of KD subjects and studied the association between bifid T waves and genetic variants in previously reported genes with SNVs associated with cardiac repolarization.
Results: Bifid T waves… More >

Zhong Liu^1,2, Xinan Wang^1,*, Kuntao Lu¹, David Su³

CMC-Computers, Materials & Continua, Vol.60, No.2, pp. 497-509, 2019, DOI:10.32604/cmc.2019.04882

Abstract ECG signal is of great importance in the clinical diagnosis of various heart diseases. The abnormal origin or conduction of excitation is the electrophysiological mechanism leading to arrhythmia, but the type and frequency of arrhythmia is an important indicator reflecting the stability of cardiac electrical activity. In clinical practice, arrhythmic signals can be classified according to the origin of excitation, the frequency of excitation, or the transmission of excitation. Traditional heart disease diagnosis depends on doctors, and it is influenced by doctors' professional skills and the department's specialty. ECG signal has the characteristics of weak signal, low frequency, large variation,… More >