Mujeebu Rehman1, Qinghua Liu1, Ali Ghulam2, Tariq Ahmad3, Jawad Khan4,*, Dildar Hussain5,*, Yeong Hyeon Gu5
CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 779-805, 2025, DOI:10.32604/cmes.2025.067412
- 30 October 2025
Abstract Identifying druggable proteins, which are capable of binding therapeutic compounds, remains a critical and resource-intensive challenge in drug discovery. To address this, we propose CEL-IDP (Comparison of Ensemble Learning Methods for Identification of Druggable Proteins), a computational framework combining three feature extraction methods Dipeptide Deviation from Expected Mean (DDE), Enhanced Amino Acid Composition (EAAC), and Enhanced Grouped Amino Acid Composition (EGAAC) with ensemble learning strategies (Bagging, Boosting, Stacking) to classify druggable proteins from sequence data. DDE captures dipeptide frequency deviations, EAAC encodes positional amino acid information, and EGAAC groups residues by physicochemical properties to generate… More >