Lifu He¹, Zhongchu Huang¹, Haidong Shao^2,*, Zhangbo Hu¹, Yuting Wang¹, Jie Mei¹, Xiaofei Zhang³

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073227 - 12 January 2026

Abstract Deep learning-based wind turbine blade fault diagnosis has been widely applied due to its advantages in end-to-end feature extraction. However, several challenges remain. First, signal noise collected during blade operation masks fault features, severely impairing the fault diagnosis performance of deep learning models. Second, current blade fault diagnosis often relies on single-sensor data, resulting in limited monitoring dimensions and ability to comprehensively capture complex fault states. To address these issues, a multi-sensor fusion-based wind turbine blade fault diagnosis method is proposed. Specifically, a CNN-Transformer Coupled Feature Learning Architecture is constructed to enhance the ability to More >

Sun Park^*, JongWon Kim

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072865 - 12 January 2026

Abstract In real-world autonomous driving tests, unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur. Conducting actual test drives under various weather conditions may also lead to dangerous situations. Furthermore, autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS. Driving simulators, which replicate driving conditions nearly identical to those in the real world, can drastically reduce the time and cost required for market entry validation; consequently, they have become widely used. In this paper, we design a virtual driving test environment capable of More >

Abdul Rahaman Wahab Sait^1,*, Yazeed Alkhurayyif²

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072481 - 12 January 2026

Abstract Malware poses a significant threat to the Internet of Things (IoT). It enables unauthorized access to devices in the IoT environment. The lack of unique architectural standards causes challenges in developing robust malware detection (MD) models. The existing models demand substantial computational resources. This study intends to build a lightweight MD model to detect anomalies in IoT networks. The authors develop a transformation technique, converting the malware binaries into images. MobileNet V2 is fine-tuned using improved grey wolf optimization (IGWO) to extract crucial features of malicious and benign samples. The ResNeXt model is combined with… More >

Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

Kai Gui^1,#, Tianyi Yang^1,#, Chengying Xiong¹, Yue Wang¹, Zhiqiang He¹, Wuxian Li^2,3,*, Min Tang^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070143 - 30 December 2025

Abstract Objectives: The mechanism by which specific tumor subsets in colorectal cancer (CRC) use alternative metabolic pathways, particularly those modulated by hypoxia and fructose, to alter the tumor microenvironment (TME) remains unclear. This study aimed to identify these malignant subpopulations and characterize their intercellular signaling networks and spatial organization through an integrative multi-omics approach. Methods: Leveraging bulk datasets, single-cell RNA sequencing, and integrative spatial transcriptomics, we developed a prognostic model based on hypoxia-and fructose metabolism-related genes (HFGs) to delineate tumor cell subpopulations and their intercellular signaling networks. Results: We identified a specific subset of stanniocalcin-2 positive (STC2+)… More > Graphic Abstract

Shaoping Xiao^1,*, Zhaoan Wang¹, Junchao Li², Caden Noeller¹, Jiefeng Jiang³, Jun Wang⁴

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-62, 2026, DOI:10.32604/cmc.2025.072146 - 09 December 2025

Abstract The integration of human factors into artificial intelligence (AI) systems has emerged as a critical research frontier, particularly in reinforcement learning (RL), where human-AI interaction (HAII) presents both opportunities and challenges. As RL continues to demonstrate remarkable success in model-free and partially observable environments, its real-world deployment increasingly requires effective collaboration with human operators and stakeholders. This article systematically examines HAII techniques in RL through both theoretical analysis and practical case studies. We establish a conceptual framework built upon three fundamental pillars of effective human-AI collaboration: computational trust modeling, system usability, and decision understandability. Our… More >

Taehoon Kim, Sehun Lee, Junho Ahn^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-30, 2026, DOI:10.32604/cmc.2025.071597 - 09 December 2025

Abstract As large, room-scale environments become increasingly common, their spatial complexity increases due to variable, unstructured elements. Consequently, demand for room-scale service robots is surging, yet most technologies remain corridor-centric, and autonomous navigation in expansive rooms becomes unstable even around static obstacles. Existing approaches face several structural limitations. These include the labor-intensive requirement for large-scale object annotation and continual retraining, as well as the vulnerability of vanishing point or line-based methods when geometric cues are insufficient. In addition, the high cost of LiDAR and 3D perception errors caused by limited wall cues and dense interior clutter… More >

Chang Su, Liangliang Zhao^*, Dongbing Xiang

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-24, 2026, DOI:10.32604/cmc.2025.071319 - 09 December 2025

Abstract To address low learning efficiency and inadequate path safety in spraying robot navigation within complex obstacle-rich environments—with dense, dynamic, unpredictable obstacles challenging conventional methods—this paper proposes a hybrid algorithm integrating Q-learning and improved A*-Artificial Potential Field (A-APF). Centered on the Q-learning framework, the algorithm leverages safety-oriented guidance generated by A-APF and employs a dynamic coordination mechanism that adaptively balances exploration and exploitation. The proposed system comprises four core modules: (1) an environment modeling module that constructs grid-based obstacle maps; (2) an A-APF module that combines heuristic search from A* algorithm with repulsive force strategies from… More >

Malvinder Singh Bali¹, Weiwei Jiang^2,*, Saurav Verma³, Kanwalpreet Kour⁴, Ashwini Rao³

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-19, 2026, DOI:10.32604/cmc.2025.070866 - 09 December 2025

Abstract In recent years, Blockchain Technology has become a paradigm shift, providing Transparent, Secure, and Decentralized platforms for diverse applications, ranging from Cryptocurrency to supply chain management. Nevertheless, the optimization of blockchain networks remains a critical challenge due to persistent issues such as latency, scalability, and energy consumption. This study proposes an innovative approach to Blockchain network optimization, drawing inspiration from principles of biological evolution and natural selection through evolutionary algorithms. Specifically, we explore the application of genetic algorithms, particle swarm optimization, and related evolutionary techniques to enhance the performance of blockchain networks. The proposed methodologies More >