YONG LIU1,2,#, ZHIHUA JU1,#, QIANG JIANG1, WENHAO LIU1, CHUNHONG YANG1, YARAN ZHANG1, XIUGE WANG1, YAPING GAO1, XIAOCHAO WEI1, YAN SUN1, JINPENG WANG1, MINGHAI HOU1, LING YANG2, JINMING HUANG1,*
BIOCELL, Vol.45, No.1, pp. 79-87, 2021, DOI:10.32604/biocell.2021.013583
Abstract F-box and WD-40 domain protein 11 (FBXW11) is an important component of the E3 ubiquitin-ligase enzyme
that plays a key role in the ubiquitin-dependent regulation of spermatogenesis. In our previous research, the mRNA
expression of FBXW11 in bull sperm with high motility is significantly higher than that with low motility. In the
present study, the protein expression levels of FBXW11 in bull testicular tissues with low-performance sperm quality
groups were significantly higher than those in normal performance groups. The immunohistochemistry result
demonstrated that FBXW11 protein was located in the periphery of Leydig cells and seminiferous tubules. Three
splice variants of… More >
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