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  • Open Access

    ARTICLE

    Optimization of a High-pressure Water-Powder Mixing Prototype for Offshore Platforms

    Shu Zheng1,*, Yang Yaln2, Shuyu Liu3, Mingxuan Xia1,2, Shaojie Li1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.3, pp. 537-548, 2022, DOI:10.32604/fdmp.2022.018500 - 22 February 2022

    Abstract A new device is designed to promote the mixing of high-pressure water jets and powders in typical industrial applications. The water and powder mixing devices traditionally used on offshore platforms are detrimentally affected by the geometrical configuration of the water nozzle and the powder spraying pipe, which are parallel, resulting in small intersecting volumes of liquid and powder. By allowing the related jets to intersect, in the present work the optimal horizontal distance, vertical distance and intersection angle are determined through a parametric investigation. It is also shown that such values change if the number More >

  • Open Access

    ARTICLE

    Intrauterine high androgen promotes obesity of the offspring of rats with polycystic ovarian syndrome via activating macrophage-angiogenesis-related androgen signaling

    MIN CHEN1,#, YUAN HUANG2,#, WEN XU2, CHUNLIN SU2,*

    BIOCELL, Vol.46, No.6, pp. 1505-1519, 2022, DOI:10.32604/biocell.2022.016564 - 07 February 2022

    Abstract The development of polycystic ovary syndrome (PCOS) is closely related to the chronic inflammatory and obese. Recent studies have found macrophages regulate the chronic inflammation and adipose tissue remodelling, but the underlying mechanisms have not been clarified. In this study, we established a model of PCOS in the offspring rats by high androgen exposure during late pregnancy in parental and established a female rat macrophage eliminating model by rejection of clodronate liposome. Then, the offspring rat macrophage phenotype in offspring female rat adipose tissue, and levels of testosterone, angiogenic factors (PDGF and VEGF) and inflammatory… More >

  • Open Access

    ARTICLE

    Effect of VirD4 on gastric epithelial-1 cells and its mechanism

    YANG YANG1,*, BENSHUAI YOU2, CHENGLIN ZHOU1,*

    BIOCELL, Vol.46, No.6, pp. 1557-1564, 2022, DOI:10.32604/biocell.2022.018326 - 07 February 2022

    Abstract The gene of Helicobacter pylori can encode three to four type IV secretory systems, of which a new gene region has been found in the H. pylori plasticity region. The coding products of this region can form a new T4SS named tfs3, but its function is unclear. This study investigated the effect of VirD4 recombinant protein in the tfs3 secretory system of the H. pylori clinical strain SBK on GES-1 cells. We observed changes in cell morphology after VirD4 treatment. Further analysis indicated that VirD4 increased inflammation by increasing the activation of NF-κB. VirD4 can also inhibited proliferation, More >

  • Open Access

    ARTICLE

    Cetyltrimethylammonium bromide inhibits the metastasis of breast cancer to the lungs by inhibiting epithelial–mesenchymal transition

    NING LI1,#, YANG CHEN2,#, YONGJIE YANG3,4, SHUHAN LYU1, YUE PAN1,5,*

    BIOCELL, Vol.46, No.6, pp. 1473-1482, 2022, DOI:10.32604/biocell.2022.018278 - 07 February 2022

    Abstract Breast cancer is a highly aggressive cancer in females. Metastasis is a major obstacle to the efficient and successful treatment of breast cancer. Cetyltrimethylammonium bromide (CTAB) has anti-tumor effects on a variety of tumors. We showed that CTAB inhibits the metastasis of breast cancer to the lungs both in vitro and in vivo. Epithelial-mesenchymal transition (EMT) is thought to be one of the major processes mediating breast cancer metastasis. We found that CTAB suppressed EMT and regulated the levels of the classical EMT markers E-cadherin, N-cadherin, vimentin, Snail and Twist1. Moreover, as a candidate anti-tumor agent, CTAB More >

  • Open Access

    ARTICLE

    Model-Free Sliding Mode Control for PMSM Drive System Based on Ultra-Local Model

    Kaihui Zhao1,2, Wenchang Liu1, Tonghuan Yin3, Ruirui Zhou4, Wangke Dai1 and Gang Huang5,*

    Energy Engineering, Vol.119, No.2, pp. 767-780, 2022, DOI:10.32604/EE.2021.018617 - 24 January 2022

    Abstract This paper presents a novel model-free sliding mode control (MFSMC) method to improve the speed response of permanent magnet synchronous machine (PMSM) drive system. The ultra-local model (ULM) is first derived based on the input and the output of the PMSM. Then, the novel MFSMC method is presented, and the controller is designed based on ULM and MFSMC. A sliding mode observer (SMO) is constructed to estimate the unknown part of the ULM. The estimated unknown part is feedbacked to MFSMC controller to perform compensation for parameter perturbations and external disturbances. Compared with the sliding More >

  • Open Access

    ARTICLE

    An EFSM-Based Test Data Generation Approach in Model-Based Testing

    Muhammad Luqman Mohd-Shafie1,*, Wan Mohd Nasir Wan Kadir1, Muhammad Khatibsyarbini1, Mohd Adham Isa1, Israr Ghani1, Husni Ruslai2

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 4337-4354, 2022, DOI:10.32604/cmc.2022.023803 - 14 January 2022

    Abstract Testing is an integral part of software development. Current fast-paced system developments have rendered traditional testing techniques obsolete. Therefore, automated testing techniques are needed to adapt to such system developments speed. Model-based testing (MBT) is a technique that uses system models to generate and execute test cases automatically. It was identified that the test data generation (TDG) in many existing model-based test case generation (MB-TCG) approaches were still manual. An automatic and effective TDG can further reduce testing cost while detecting more faults. This study proposes an automated TDG approach in MB-TCG using the extended… More >

  • Open Access

    ARTICLE

    FSpot: Fast and Efficient Video Encoding Workloads Over Amazon Spot Instances

    Anatoliy Zabrovskiy1,3, Prateek Agrawal1,2,*, Vladislav Kashansky1, Roland Kersche4, Christian Timmerer1,4, Radu Prodan1

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 5677-5697, 2022, DOI:10.32604/cmc.2022.023630 - 14 January 2022

    Abstract HTTP Adaptive Streaming (HAS) of video content is becoming an undivided part of the Internet and accounts for most of today's network traffic. Video compression technology plays a vital role in efficiently utilizing network channels, but encoding videos into multiple representations with selected encoding parameters is a significant challenge. However, video encoding is a computationally intensive and time-consuming operation that requires high-performance resources provided by on-premise infrastructures or public clouds. In turn, the public clouds, such as Amazon elastic compute cloud (EC2), provide hundreds of computing instances optimized for different purposes and clients’ budgets. Thus,… More >

  • Open Access

    ARTICLE

    A BPR-CNN Based Hand Motion Classifier Using Electric Field Sensors

    Hunmin Lee1, Inseop Na2, Kamoliddin Bultakov3, Youngchul Kim3,*

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 5413-5425, 2022, DOI:10.32604/cmc.2022.023172 - 14 January 2022

    Abstract In this paper, we propose a BPR-CNN (Biometric Pattern Recognition-Convolution Neural Network) classifier for hand motion classification as well as a dynamic threshold algorithm for motion signal detection and extraction by EF (Electric Field) sensors. Currently, an EF sensor or EPS (Electric Potential Sensor) system is attracting attention as a next-generation motion sensing technology due to low computation and price, high sensitivity and recognition speed compared to other sensor systems. However, it remains as a challenging problem to accurately detect and locate the authentic motion signal frame automatically in real-time when sensing body-motions such as… More >

  • Open Access

    ARTICLE

    The Method of Fundamental Solutions for Two-Dimensional Elastostatic Problems with Stress Concentration and Highly Anisotropic Materials

    M. R. Hematiyan1,*, B. Jamshidi1, M. Mohammadi2

    CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.3, pp. 1349-1369, 2022, DOI:10.32604/cmes.2022.018235 - 30 December 2021

    Abstract The method of fundamental solutions (MFS) is a boundary-type and truly meshfree method, which is recognized as an efficient numerical tool for solving boundary value problems. The geometrical shape, boundary conditions, and applied loads can be easily modeled in the MFS. This capability makes the MFS particularly suitable for shape optimization, moving load, and inverse problems. However, it is observed that the standard MFS lead to inaccurate solutions for some elastostatic problems with stress concentration and/or highly anisotropic materials. In this work, by a numerical study, the important parameters, which have significant influence on the… More >

  • Open Access

    ARTICLE

    FileWallet: A File Management System Based on IPFS and Hyperledger Fabric

    Jienan Chen, Chuang Zhang, Yu Yan, Yuan Liu*

    CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.2, pp. 949-966, 2022, DOI:10.32604/cmes.2022.017516 - 13 December 2021

    Abstract Online file management systems enable cooperatively editing and sharing. However, due to the cost of communication and storage infrastructures, traditional online file management services, e.g., Google Drive and OneDrive, usually provide limited storage space and relatively low download speed for free users. To achieve better performance, ordinary users have to purchase their expensive services. Moreover, these file management systems are based on centralized architecture and bear the privacy leakage risk, because users’ personal files are stored and controlled by their servers. To address the above problems, we propose a peer-to-peer (P2P) file management system based… More >

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