Ram P. Ghosh¹, Matteo Bianchi¹, Gil Marom², Oren M. Rotman¹, Brandon Kovarovic¹, Danny Bluestein^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 12-14, 2019, DOI:10.32604/mcb.2019.07379

Abstract This article has no abstract. More >

Yahui Zhang¹, Hui Wang^1,2, Zhouming Mai^1,2, Jianhang Du^1,2,3,*, Guifu Wu^1,2,3

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 85-86, 2019, DOI:10.32604/mcb.2019.05836

Abstract Enhanced external counter pulsation (EECP) is an effective therapy to provide beneficial assistance for the failing heart by reducing cardiac afterload and increasing blood flow perfusion noninvasively. The technique of EECP involves the use of the EECP device to inflate and deflate a series of compression cuffs wrapped around the patient’s calves, lower thighs, and upper thighs. As the result, the enhanced flow perfusion is derived from the device’s propelling blood from veins of lower body to arteries of upper body and increases the blood supply for the important organs and brain. In the ACCF/AHA Guideline and ESC Guideline on… More >

Xiaoya Guo¹, Dalin Tang^1,2,*, David Molony³, Chun Yang², Habib Samady³, Jie Zheng⁴, Gary S. Mintz⁵, Akiko Maehara⁵, Jian Zhu⁶, Genshan Ma⁶, Mitsuaki Matsumura⁵, Don P. Giddens^3,7

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 75-76, 2019, DOI:10.32604/mcb.2019.05743

Abstract Atherosclerotic plaque progression is generally considered to be closely associated with morphological and mechanical factors. Plaque morphological information on intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images could complement each other and provide for more accurate plaque morphology. Fluid-structure interaction (FSI) models combining IVUS and OCT were constructed to obtain accurate plaque stress/strain and flow shear stress data for analysis. Accuracy and completeness of imaging and advanced modeling lead to accurate plaque progression predictions.
In vivo IVUS and OCT coronary plaque data at baseline and follow-up were acquired from left circumflex coronary and right coronary artery of one… More >

Longling Fan¹, Jing Yao², Chun Yang³, Di Xu², Dalin Tang^1,4,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 41-41, 2019, DOI:10.32604/mcb.2019.05720

Abstract Cardiac pacing has been an effective treatment in the management of patients with arrhythmia. Different pacemaker location may have different impact on pacemaker effectiveness. A novel image-based ventricle animal modeling approach was proposed to integrate echocardiography images, propagating dynamic electric potential on ventricle surface to perform myocardial function assessment. The models will be used to simulate ventricular electrical signal conduction and optimize pacemaker location for better cardiac outcome. One health female adult pig weight 42.5 kg was used to make pacing animal model with different ventricle pacing locations. Pig health status was assessed before undergoing experimental procedures. Ventricle surface electric… More >

O. Ohta¹, F. Gao¹, T. Matsuzawa²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.7, No.3, pp. 146-150, 2008, DOI:10.3970/icces.2008.007.146

Abstract The aortic disease is 2nd place of the cause of death. If the thoracic part and the dissociation are matched, the aortic aneurysm exceeds 60 percent. The aneurysm decided based on the maximum diameter of the aneurysm from the image of which it takes a picture with CT or MRI etc. as such a diagnostic indicator. The appearance of disease, the development, and the rupture of the arterial hemangioma are thought that the hemodynamics such as intravasculars and vessel walls plays an important role [1,2]. Then, we simulated the aneurysm of descending aorta in consideration of the vessel wall of… More >

S.T. Jenq^1,2, Y.S. Chiu², Y.C. Ting²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.4, pp. 263-264, 2009, DOI:10.3970/icces.2009.009.263

Abstract The purpose of this work is to study the transient hydroplaning behavior of inflated pneumatic 195/65R15 radial tires with various tread patterns and the tires were loaded with a quarter car weight. The tires were analyzed numerically to roll over a water film with a thickness of 5 mm, 10 mm and 15 mm on top of a flat-road pavement. Current tire structure contains the outer rubber tread and the inner advanced reinforcing composite layers. The Mooney-Rivlin constitutive law and the classical laminated theory (CLT) were used to describe the behavior of the large-deformable rubber tread material and reinforcing composite… More >

Jianhang Du^1,2,3, Liang Wang⁴

Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249

Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was performed in vivo before and… More >

Xueying Huang^*, Chun Yang^†, Chun Yuan^‡, Fei Liu^‡, Gador Canton^‡, Jie Zheng^§, Pamela K. Woodard^§, Gregorio A. Sicard^¶, Dalin Tang^||

Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 121-134, 2009, DOI:10.3970/mcb.2009.006.121

Abstract Image-based computational models for atherosclerotic plaques have been developed to perform mechanical analysis to quantify critical flow and stress/strain conditions related to plaque rupture which often leads directly to heart attack or stroke. An important modeling issue is how to determine zero stress state from in vivo plaque geometries. This paper presents a method to quantify human carotid artery axial and inner circumferential shrinkages by using patient-specific ex vivo and in vivo MRI images. A shrink-stretch process based on patient-specific in vivo plaque morphology and shrinkage data was introduced to shrink the in vivo geometry first to find the zero-stress… More >

Dalin Tang^*, Chun Yang^†, Tal Geva^‡,§, Pedro J. del Nido^¶

Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 159-176, 2007, DOI:10.3970/mcb.2007.004.159

Abstract A single-layer isotropic patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced in our previous papers to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. In this paper, an active anisotropic model with two-layer structure for ventricle wall and tissue fiber orientation was introduced to improve previous isotropic model for more accurate assessment of RV function and potential application in PVR surgery and patch design. A material-stiffening approach was used to model active heart contraction. The computational models were used to conduct ``virtual (computational)'' surgeries and test the hypothesis that… More >

Long Deng¹, Xueying Huang^2,3,*, Heng Zuo⁴, Yuan Zheng², Chun Yang⁵, Yunhu Song¹, Dalin Tang⁶

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 115-125, 2018, DOI: 10.31614/cmes.2018.04076

Abstract The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t wao vs. 56.2±56.o, p=0.306, n=5).… More >