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  • Open Access


    Impact of Plaque Erosion on Stress/Strain and Flow Shear Stress Calculation: An OCT-Based FSI Modeling Study

    Liang Wang1, Haibo Jia2, Luping He2, Rui Lv1, Xiaoya Guo3, Chun Yang4,5, Don P. Giddens6,7, Habib Samady6, Akiko Maehara8, Gary S. Mintz8, Dalin Tang1,*,5

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 23-24, 2019, DOI:10.32604/mcb.2019.07522

    Abstract Plaque erosion, one of the primary causes for coronary thrombosis, is responsible for about one third of the patients with acute coronary syndrome (ACS) [1]. Histological studies characterized the eroded plaque as a plaque with following morphological features: 1) plaque intima having direct contact with intraluminal thrombus due to the absence of endothelium or endothelial injury; 2) without rupture in the fibrous cap; 3) abundance of proteoglycans and smooth muscle cells on the luminal surface under the thrombus [2]. These characteristics has been applied in in vivo diagnosis of plaque erosion using optical coherence tomography… More >

  • Open Access


    Patient-Specific Computational Approach for Trans Catheter Aortic Valve Replacement (TAVR): Pre-Procedural Planning for Enhancing Performance and Clinical Outcomes

    Ram P. Ghosh1, Matteo Bianchi1, Gil Marom2, Oren M. Rotman1, Brandon Kovarovic1, Danny Bluestein1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 12-14, 2019, DOI:10.32604/mcb.2019.07379

    Abstract This article has no abstract. More >

  • Open Access


    The Influence of Enhanced External Counterpulsation Intervention on the Biomechanical Stress Distribution of Advanced Plaque: A 3D FSI Study Based on in vivo Animal Experiment

    Yahui Zhang1, Hui Wang1,2, Zhouming Mai1,2, Jianhang Du1,2,3,*, Guifu Wu1,2,3

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 85-86, 2019, DOI:10.32604/mcb.2019.05836

    Abstract Enhanced external counter pulsation (EECP) is an effective therapy to provide beneficial assistance for the failing heart by reducing cardiac afterload and increasing blood flow perfusion noninvasively. The technique of EECP involves the use of the EECP device to inflate and deflate a series of compression cuffs wrapped around the patient’s calves, lower thighs, and upper thighs. As the result, the enhanced flow perfusion is derived from the device’s propelling blood from veins of lower body to arteries of upper body and increases the blood supply for the important organs and brain. In the ACCF/AHA… More >

  • Open Access


    Predicting Plaque Progression Using Patient-Specific Fluid-Structure-Interaction Models Based on IVUS and OCT Images with Follow-Up

    Xiaoya Guo1, Dalin Tang1,2,*, David Molony3, Chun Yang2, Habib Samady3, Jie Zheng4, Gary S. Mintz5, Akiko Maehara5, Jian Zhu6, Genshan Ma6, Mitsuaki Matsumura5, Don P. Giddens3,7

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 75-76, 2019, DOI:10.32604/mcb.2019.05743

    Abstract Atherosclerotic plaque progression is generally considered to be closely associated with morphological and mechanical factors. Plaque morphological information on intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images could complement each other and provide for more accurate plaque morphology. Fluid-structure interaction (FSI) models combining IVUS and OCT were constructed to obtain accurate plaque stress/strain and flow shear stress data for analysis. Accuracy and completeness of imaging and advanced modeling lead to accurate plaque progression predictions.
    In vivo IVUS and OCT coronary plaque data at baseline and follow-up were acquired from left circumflex coronary and right coronary… More >

  • Open Access


    Echo-Based FSI Models to Simulate Ventricular Electrical Signal Conduction in Pig Pacemaker Models

    Longling Fan1, Jing Yao2, Chun Yang3, Di Xu2, Dalin Tang1,4,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 41-41, 2019, DOI:10.32604/mcb.2019.05720

    Abstract Cardiac pacing has been an effective treatment in the management of patients with arrhythmia. Different pacemaker location may have different impact on pacemaker effectiveness. A novel image-based ventricle animal modeling approach was proposed to integrate echocardiography images, propagating dynamic electric potential on ventricle surface to perform myocardial function assessment. The models will be used to simulate ventricular electrical signal conduction and optimize pacemaker location for better cardiac outcome. One health female adult pig weight 42.5 kg was used to make pacing animal model with different ventricle pacing locations. Pig health status was assessed before undergoing… More >

  • Open Access


    The Descending Aortic Aneurysm under Vascular Structure having Three-layered using FSI

    O. Ohta1, F. Gao1, T. Matsuzawa2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.7, No.3, pp. 146-150, 2008, DOI:10.3970/icces.2008.007.146

    Abstract The aortic disease is 2nd place of the cause of death. If the thoracic part and the dissociation are matched, the aortic aneurysm exceeds 60 percent. The aneurysm decided based on the maximum diameter of the aneurysm from the image of which it takes a picture with CT or MRI etc. as such a diagnostic indicator. The appearance of disease, the development, and the rupture of the arterial hemangioma are thought that the hemodynamics such as intravasculars and vessel walls plays an important role [1,2]. Then, we simulated the aneurysm of descending aorta in consideration More >

  • Open Access


    Transient hydroplaning simulation of automotive tires using the fluid-structure interaction finite element method

    S.T. Jenq1,2, Y.S. Chiu2, Y.C. Ting2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.4, pp. 263-264, 2009, DOI:10.3970/icces.2009.009.263

    Abstract The purpose of this work is to study the transient hydroplaning behavior of inflated pneumatic 195/65R15 radial tires with various tread patterns and the tires were loaded with a quarter car weight. The tires were analyzed numerically to roll over a water film with a thickness of 5 mm, 10 mm and 15 mm on top of a flat-road pavement. Current tire structure contains the outer rubber tread and the inner advanced reinforcing composite layers. The Mooney-Rivlin constitutive law and the classical laminated theory (CLT) were used to describe the behavior of the large-deformable rubber… More >

  • Open Access


    Enhanced External Counterpulsation Treatment May Intervene The Advanced Atherosclerotic Plaque Progression by Inducing The Variations of Mechanical Factors: A 3D FSI Study Based on in vivo Animal Experiment

    Jianhang Du1,2,3, Liang Wang4

    Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249

    Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was… More >

  • Open Access


    Patient-Specific Artery Shrinkage and 3D Zero-Stress State in Multi-Component 3D FSI Models for Carotid Atherosclerotic Plaques Based on In Vivo MRI Data

    Xueying Huang*, Chun Yang, Chun Yuan, Fei Liu, Gador Canton, Jie Zheng§, Pamela K. Woodard§, Gregorio A. Sicard, Dalin Tang||

    Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 121-134, 2009, DOI:10.3970/mcb.2009.006.121

    Abstract Image-based computational models for atherosclerotic plaques have been developed to perform mechanical analysis to quantify critical flow and stress/strain conditions related to plaque rupture which often leads directly to heart attack or stroke. An important modeling issue is how to determine zero stress state from in vivo plaque geometries. This paper presents a method to quantify human carotid artery axial and inner circumferential shrinkages by using patient-specific ex vivo and in vivo MRI images. A shrink-stretch process based on patient-specific in vivo plaque morphology and shrinkage data was introduced to shrink the in vivo geometry first to find the zero-stress… More >

  • Open Access


    Two-Layer Passive/Active Anisotropic FSI Models with Fiber Orientation: MRI-Based Patient-Specific Modeling of Right Ventricular Response to Pulmonary Valve Insertion Surgery

    Dalin Tang*, Chun Yang, Tal Geva‡,§, Pedro J. del Nido

    Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 159-176, 2007, DOI:10.3970/mcb.2007.004.159

    Abstract A single-layer isotropic patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced in our previous papers to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. In this paper, an active anisotropic model with two-layer structure for ventricle wall and tissue fiber orientation was introduced to improve previous isotropic model for more accurate assessment of RV function and potential application in PVR surgery and patch design. A material-stiffening approach was used to model active heart contraction. The computational models were used to conduct ``virtual (computational)'' surgeries More >

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