Kathiravan Srinivasan¹, Lalit Garg^2,*, Debajit Datta³, Abdulellah A. Alaboudi⁴, N. Z. Jhanjhi⁵, Rishav Agarwal³, Anmol George Thomas¹

CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 4109-4124, 2021, DOI:10.32604/cmc.2021.016736 - 06 May 2021

Abstract According to various worldwide statistics, most car accidents occur solely due to human error. The person driving a car needs to be alert, especially when travelling through high traffic volumes that permit high-speed transit since a slight distraction can cause a fatal accident. Even though semi-automated checks, such as speed detecting cameras and speed barriers, are deployed, controlling human errors is an arduous task. The key causes of driver’s distraction include drunken driving, conversing with co-passengers, fatigue, and operating gadgets while driving. If these distractions are accurately predicted, the drivers can be alerted through an More >

Shuo Qu¹, Yaolei Jiao², Lamboro Abraham², Piwu Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.90, No.4, pp. 1177-1192, 2021, DOI:10.32604/phyton.2021.015206 - 27 April 2021

Abstract The fatty acid dehydrogenase gene plays an important role in regulating the oleic acid content in soybean. Genome-wide association study screened out soybean oleic acid related gene Gm15G117700. A fragment size of 693bp was obtained by PCR amplification of the gene and, it was connected by seamless cloning technology to the pMD18T cloning vector. Based on the gene sequence cloned, bioinformatic analysis of gene protein was performed. The overexpression vector of Gm15G117700 and the CRISPR/Cas9 gene editing vector were constructed. The positive plants were obtained by Agrobacterium-mediated transformation of soybean cotyledon nodes and T₂ plants were… More >

Yuan Liu^1,2,#, Yun Jia³, Bing Zhang², Anwen Liu^1,*

Oncologie, Vol.23, No.1, pp. 61-72, 2021, DOI:10.32604/Oncologie.2021.015906 - 30 March 2021

Abstract Gastric cancer (GC) is the most common digestive system malignant tumor and second most common cause of cancer-related death. Even for the early gastric cancer, after radical operation, perioperative and postoperative chemotherapy the recurrence and metastasis are also high. 5-year overall survival of all GC patients is only 10–15%. Chemo-resistance still poses a major obstacle to successful treatment of GC. The aberrant expression of TUG1 (Taurine Upregulated Gene 1) was closely related to chemo-resistance and metastasis in many cancers. Here we over-expressed TUG1 in GC cell line SGC-7901 and MGC-803. We compared the migration ability More >

Pengfei Gong^1,2, Qun Wang^2,*, Junjun Zhu³

CMC-Computers, Materials & Continua, Vol.68, No.1, pp. 1389-1408, 2021, DOI:10.32604/cmc.2021.016483 - 22 March 2021

Abstract Fatal traffic accidents in urban areas can adversely affect the urban road traffic system and pose many challenges for urban traffic management. Therefore, it is necessary to first classify emergency responses to such accidents and then handle them quickly and correctly. The aim of this paper is to develop an evaluation index system and to use appropriate methods to investigate emergency-response classifications to fatal traffic accidents in Chinese urban areas. This study used a multilevel hierarchical structural model to determine emergency-response classification. In the model, accident attributes, urban road network vulnerability, and institutional resilience were… More >

Yuqin Xie¹, Shuang Deng¹, Qian Deng², Jiudong Xu^*

Oncologie, Vol.22, No.3, pp. 179-188, 2020, DOI:10.32604/Oncologie.2020.012544

Abstract This study aimed to explore LncRNA TUG1 targeted miR-222-3p in the proliferation and invasion of breast cancer (BC) cells. Seventy-six BC patients admitted to our hospital and 62 health check-ups at the same time were selected as the research objects. Among them, the former was seen as the observation group (OG), and the latter was considered as the control group (CG). The clinical significance of LncRNA TUG1 and miR-222-3p in BC was detected. Human BC cell MCF7 and normal human breast epithelial cell MCF-10A were purchased. After cells were transfected with LncRNA TUG1 and miR-222-3p,… More >

Danni He, Guoli Deng, Songpei Ying, Wenjuan Yang, Jiali Wei, Ping Li^*

Phyton-International Journal of Experimental Botany, Vol.89, No.3, pp. 633-643, 2020, DOI:10.32604/phyton.2020.010498 - 22 June 2020

Abstract Primary seed dormancy is an adaptive strategy that prevents germination for viable seeds in harsh environment, ensuring seeds germination under favorable condition. Accurately inducing seeds germination in a controllable manner is important for crop production. Thus searching the chemicals that efficiently breaks seed dormancy is valuable. DOG1 protein abundance in the freshly harvested seed is high, and its level is correlated to seed dormancy intensity, thus DOG1 is regarded as the timer to evaluate the seed dormancy degree. In this study, we found the carbon monoxide (CO) donor treatment, the transgenic line with high CO… More >

Ping Li^*, Huanhuan Ni, Songbei Ying, Jiali Wei, Xiangyang Hu

Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 1-12, 2020, DOI:10.32604/phyton.2020.09817 - 01 March 2020

Abstract Primary seed dormancy is a critical trait for sustainable agricultural development, ensuring seed germination under favorable conditions. The induction, maintenance and release of seed dormancy is a complicated physiological process that is strictly controlled by a variety of endogenous signals and environmental factors. In Arabidopsis, DOG1 (DELAY OF GERMINATION 1) is identi- fied as the main quantitative trait locus (QTL) of seed dormancy, which contributes to deep dormancy in the Cvi ecotype. In recent years, considerable progress has been made to elucidate the molecular regulatory mechanism by which DOG1 controls seed dormancy. In this review, we describe a More >

Ling Ding^{1, 2}, Huyin Zhang^{1, *}, Jinsheng Xiao^{3, *}, Cheng Shu³, Shejie Lu²

CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.3, pp. 1039-1053, 2020, DOI:10.32604/cmes.2020.08268 - 01 March 2020

Abstract This paper proposes a novel method of lane detection, which adopts VGG16 as the basis of convolutional neural network to extract lane line features by cavity convolution, wherein the lane lines are divided into dotted lines and solid lines. Expanding the field of experience through hollow convolution, the full connection layer of the network is discarded, the last largest pooling layer of the VGG16 network is removed, and the processing of the last three convolution layers is replaced by hole convolution. At the same time, CNN adopts the encoder and decoder structure mode, and uses… More >

Changyu Liu^*, Yongde Liao^*, Sheng Fan^*, Xiangning Fu^*, Jing Xiong^†, Sheng Zhou^†, Man Zou^‡, Jianmiao Wang^§

Oncology Research, Vol.27, No.3, pp. 283-292, 2019, DOI:10.3727/096504017X15035795904677

Abstract G-protein-coupled estrogen receptor (GPER) was found to promote non-small cell lung cancer (NSCLC) by estrogen, indicating the potential necessity of inhibiting GPER by a selective antagonist. This study was performed to elucidate the function of GPER-selective inhibitor G15 in NSCLC development. Cytoplasmic GPER (cGPER) and nuclear GPER (nGPER) were detected by immunohistochemical analysis in NSCLC samples. The relation of GPER and estrogen receptor (ER ) expression and correlation between GPER, ER , and clinical factors were analyzed. The effects of activating GPER and function of G15 were analyzed in the proliferation of A549 and H1793… More >

Zhen Li^*1, Xin Li^*1, Xiao Du^†, Henghui Zhang^†, Zhengyang Wu^*, Kewei Ren^*, Xinwei Han^*

Oncology Research, Vol.27, No.6, pp. 663-672, 2019, DOI:10.3727/096504018X15420741307616

Abstract Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary carcinoma. The long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported to contribute to the progression of multiple cancers. Nonetheless, the functions and hidden mechanism of SNHG1 remain unclear in CCA. In this study, the SNHG1 levels were boosted in CCA cell lines, and knockdown of SNHG1 repressed CCA cell proliferation and invasion in vitro. The data also demonstrated that miR-140 could act as a target of SNHG1 in CCA and inhibited CCA cell proliferation and invasion, whereas the inhibition effects More >