HAN WANG, YINGYING ZHOU, SIYANG ZHANG, YA QI, MIN WANG^*

Oncology Research, Vol.29, No.4, pp. 275-289, 2021, DOI:10.32604/or.2022.03561 - 31 August 2022

Abstract Metastasis and paclitaxel (PTX) resistance are the main reason for the poor prognosis of ovarian cancer (OC). Evidence showed that RNA-binding proteins (RBPs) and long noncoding RNAs (lncRNAs) can modulate post-transcriptional regulation. The aim of this study was to determine the relationship among RBP, lncRNA and OC and to further guide clinical therapy. Immunohistochemistry revealed that pre-mRNA processing factor 6 (PRPF6) was upregulated in OC chemoresistant tissues and was closely related to advanced (Federation of International of Gynecologists and Obstetricians) FIGO stages and chemo-resistance. PRPF6 promoted progression, and PTX resistance in vitro and in vivo. And the… More >

Yuqin Xie, Shuang Deng, Qian Deng, Jiudong Xu

Oncologie, Vol.23, No.4, pp. 609-609, 2021, DOI:10.32604/oncologie.2021.020379 - 31 December 2021

Abstract This article has no abstract. More >

Tao Zhang^1,2, Zhanjie Zhang^1,2,*, Wenjing Jia³, Xiangjian He³, Jie Yang⁴

CMC-Computers, Materials & Continua, Vol.69, No.2, pp. 2733-2747, 2021, DOI:10.32604/cmc.2021.019305 - 21 July 2021

Abstract The generative adversarial network (GAN) is first proposed in 2014, and this kind of network model is machine learning systems that can learn to measure a given distribution of data, one of the most important applications is style transfer. Style transfer is a class of vision and graphics problems where the goal is to learn the mapping between an input image and an output image. CYCLE-GAN is a classic GAN model, which has a wide range of scenarios in style transfer. Considering its unsupervised learning characteristics, the mapping is easy to be learned between an… More >

Xiaofan Deng^1,2, Yamei Yang^2,3, Xianfeng Gan^2,3, Gang Wu^2,3,*

Oncologie, Vol.23, No.2, pp. 251-258, 2021, DOI:10.32604/Oncologie.2021.016900 - 22 June 2021

Abstract microRNA-422a (miR-422a) is downregulated in many hematopoietic tumors and solid tumors including hepatocellular carcinoma. We previously demonstrated that hepatitis B virus X protein (HBx) downregulated expression of miR-422a in HCC cell line HepG2 in vitro. However, we explore the mechanisms underlying this action. Forkhead box proteins (FOX) G1/Q1/E1 are known to negatively regulate miR-422a expression, and this prompted us to determine whether HBx suppresses miR-422a expression via activation of FOXG1/Q1/E1. The relationship between FOXG1/Q1/E1 and miR-422a in HepG2 cells stably expressing HBx was assessed with qRT-PCR. The correlation between HBx and FOXG1/Q1/E1 was determined with qRT-PCR More >

Kathiravan Srinivasan¹, Lalit Garg^2,*, Debajit Datta³, Abdulellah A. Alaboudi⁴, N. Z. Jhanjhi⁵, Rishav Agarwal³, Anmol George Thomas¹

CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 4109-4124, 2021, DOI:10.32604/cmc.2021.016736 - 06 May 2021

Abstract According to various worldwide statistics, most car accidents occur solely due to human error. The person driving a car needs to be alert, especially when travelling through high traffic volumes that permit high-speed transit since a slight distraction can cause a fatal accident. Even though semi-automated checks, such as speed detecting cameras and speed barriers, are deployed, controlling human errors is an arduous task. The key causes of driver’s distraction include drunken driving, conversing with co-passengers, fatigue, and operating gadgets while driving. If these distractions are accurately predicted, the drivers can be alerted through an More >

Shuo Qu¹, Yaolei Jiao², Lamboro Abraham², Piwu Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.90, No.4, pp. 1177-1192, 2021, DOI:10.32604/phyton.2021.015206 - 27 April 2021

Abstract The fatty acid dehydrogenase gene plays an important role in regulating the oleic acid content in soybean. Genome-wide association study screened out soybean oleic acid related gene Gm15G117700. A fragment size of 693bp was obtained by PCR amplification of the gene and, it was connected by seamless cloning technology to the pMD18T cloning vector. Based on the gene sequence cloned, bioinformatic analysis of gene protein was performed. The overexpression vector of Gm15G117700 and the CRISPR/Cas9 gene editing vector were constructed. The positive plants were obtained by Agrobacterium-mediated transformation of soybean cotyledon nodes and T₂ plants were… More >

Yuan Liu^1,2,#, Yun Jia³, Bing Zhang², Anwen Liu^1,*

Oncologie, Vol.23, No.1, pp. 61-72, 2021, DOI:10.32604/Oncologie.2021.015906 - 30 March 2021

Abstract Gastric cancer (GC) is the most common digestive system malignant tumor and second most common cause of cancer-related death. Even for the early gastric cancer, after radical operation, perioperative and postoperative chemotherapy the recurrence and metastasis are also high. 5-year overall survival of all GC patients is only 10–15%. Chemo-resistance still poses a major obstacle to successful treatment of GC. The aberrant expression of TUG1 (Taurine Upregulated Gene 1) was closely related to chemo-resistance and metastasis in many cancers. Here we over-expressed TUG1 in GC cell line SGC-7901 and MGC-803. We compared the migration ability More >

Pengfei Gong^1,2, Qun Wang^2,*, Junjun Zhu³

CMC-Computers, Materials & Continua, Vol.68, No.1, pp. 1389-1408, 2021, DOI:10.32604/cmc.2021.016483 - 22 March 2021

Abstract Fatal traffic accidents in urban areas can adversely affect the urban road traffic system and pose many challenges for urban traffic management. Therefore, it is necessary to first classify emergency responses to such accidents and then handle them quickly and correctly. The aim of this paper is to develop an evaluation index system and to use appropriate methods to investigate emergency-response classifications to fatal traffic accidents in Chinese urban areas. This study used a multilevel hierarchical structural model to determine emergency-response classification. In the model, accident attributes, urban road network vulnerability, and institutional resilience were… More >

Yuqin Xie¹, Shuang Deng¹, Qian Deng², Jiudong Xu^*

Oncologie, Vol.22, No.3, pp. 179-188, 2020, DOI:10.32604/Oncologie.2020.012544

Abstract This study aimed to explore LncRNA TUG1 targeted miR-222-3p in the proliferation and invasion of breast cancer (BC) cells. Seventy-six BC patients admitted to our hospital and 62 health check-ups at the same time were selected as the research objects. Among them, the former was seen as the observation group (OG), and the latter was considered as the control group (CG). The clinical significance of LncRNA TUG1 and miR-222-3p in BC was detected. Human BC cell MCF7 and normal human breast epithelial cell MCF-10A were purchased. After cells were transfected with LncRNA TUG1 and miR-222-3p,… More >

Danni He, Guoli Deng, Songpei Ying, Wenjuan Yang, Jiali Wei, Ping Li^*

Phyton-International Journal of Experimental Botany, Vol.89, No.3, pp. 633-643, 2020, DOI:10.32604/phyton.2020.010498 - 22 June 2020

Abstract Primary seed dormancy is an adaptive strategy that prevents germination for viable seeds in harsh environment, ensuring seeds germination under favorable condition. Accurately inducing seeds germination in a controllable manner is important for crop production. Thus searching the chemicals that efficiently breaks seed dormancy is valuable. DOG1 protein abundance in the freshly harvested seed is high, and its level is correlated to seed dormancy intensity, thus DOG1 is regarded as the timer to evaluate the seed dormancy degree. In this study, we found the carbon monoxide (CO) donor treatment, the transgenic line with high CO… More >