LONGSHENG FU¹, JINFANG HU¹, FENG SHAO², YAOQI WU¹, WEI BAI³, MINGJIN JIANG³, HAO CHEN⁴, LIHUA CHEN², YANNI LV^1,*

BIOCELL, Vol.47, No.8, pp. 1869-1883, 2023, DOI:10.32604/biocell.2023.028602 - 28 August 2023

Abstract Background: Biochanin A is an excellent dietary isoflavone that has the concomitant function of both medicine and foodstuff. The attenuation function of biochanin A on blood-brain barrier (BBB) damage induced by cerebral ischemia-reperfusion remains unclear. Methods: C57BL/6 mice were subjected to 1 h middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion. The infarct volume of the brain was stained by TTC, while leakage of the brain was quantitatively stained by Evans blue, and the neurologic deficit score was measured. Microglial-induced morphologic changes were observed via immunofluorescence staining, and rolling and adhering leukocytes in… More >

Jinlan Xu^*, Shuxin Xiao, Gang Xu, Renshu Gu

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.2, pp. 1957-1973, 2023, DOI:10.32604/cmes.2023.028665 - 26 June 2023

Abstract In this paper, we propose a parameterization transfer algorithm for planar domains bounded by B-spline curves, where the shapes of the planar domains are similar. The domain geometries are considered to be similar if their simplified skeletons have the same structures. One domain we call source domain, and it is parameterized using multi-patch B-spline surfaces. The resulting parameterization is C1 continuous in the regular region and G1 continuous around singular points regardless of whether the parameterization of the source domain is C1/G1 continuous or not. In this algorithm, boundary control points of the source domain… More >

YUE GUAN^1,#, TINGTING ZHANG^2,#, JIANAN YU³, JIAWEI LIU⁴, WENYUAN LI⁵, YUJIA ZHENG⁶, JIALE WANG³, YUE LIU³, FENGGUO ZHAI^2,7,*

BIOCELL, Vol.47, No.7, pp. 1583-1594, 2023, DOI:10.32604/biocell.2023.028016 - 21 June 2023

Abstract Background: A preliminary miRNA screening showed that expression levels of rno-miRNA-27a-3p were significantly increased in the serum and brain tissues of rats undergoing cerebral ischemia. In recent years, there is evidence of the protective capacity of the saponins extracted from panax ginseng and its primary active ingredient ginsenosideRg1oncerebral ischemic injury. Methods: Fetal rat neurons (FRNs) were cultured in glucose-and-serum-free medium and exposed to hypoxia to establish a cerebral ischemia model in vitro (oxygen and glucose deprivation model, OGD). Antioxidant indexes (CAT, SOD), inflammatory markers (MPO, TNF-α and IL-6), and the expression of apoptosis and proliferation associated… More >

Deepika Saravagi¹, Shweta Agrawal^2,*, Manisha Saravagi³, Sanjiv K. Jain⁴, Bhisham Sharma⁵, Abolfazl Mehbodniya^6,*, Subrata Chowdhury⁷, Julian L. Webber⁶

Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 2133-2151, 2023, DOI:10.32604/iasc.2023.039836 - 21 June 2023

Abstract Spondylolisthesis is a chronic disease, and a timely diagnosis of it may help in avoiding surgery. Disease identification in x-ray radiographs is very challenging. Strengthening the feature extraction tool in VGG16 has improved the classification rate. But the fully connected layers of VGG16 are not efficient at capturing the positional structure of an object in images. Capsule network (CapsNet) works with capsules (neuron clusters) rather than a single neuron to grasp the properties of the provided image to match the pattern. In this study, an integrated model that is a combination of VGG16 and CapsNet… More >

Mohammed A. Al Ghamdi^*

CMC-Computers, Materials & Continua, Vol.76, No.1, pp. 881-894, 2023, DOI:10.32604/cmc.2023.037826 - 08 June 2023

Abstract Considerable resources, technology, and efforts are being utilized worldwide to eradicate the coronavirus. Although certain measures taken to prevent the further spread of the disease have been successful, efforts to completely wipe out the coronavirus have been insufficient. Coronavirus patients have symptoms similar to those of chest Tuberculosis (TB) or pneumonia patients. Chest tuberculosis and coronavirus are similar because both diseases affect the lungs, cause coughing and produce an irregular respiratory system. Both diseases can be confirmed through X-ray imaging. It is a difficult task to diagnose COVID-19, as coronavirus testing kits are neither excessively… More >

Xi Liu^1,2,#,*, Chuxuan Zhao^2,#, Di Wang^3,#, Gen Pan⁴, Xiaonan Ji², Su Gao², Tanxiao Du², Yating Feng², Wenjing Chen²

Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2051-2064, 2023, DOI:10.32604/phyton.2023.028196 - 29 May 2023

Abstract Many studies have already shown that dwarfism and moderate delayed leaf senescence positively impact rice yield, but the underlying molecular mechanism of dwarfism and leaf senescence remains largely unknown. Here, using map-based cloning, we identified an allele of DEP2, DDG1, which controls plant height and leaf senescence in rice. The ddg1 mutant displayed dwarfism, short panicles, and delayed leaf senescence. Compared with the wild-type, ddg1 was insensitive to exogenous gibberellins (GA) and brassinolide (BR). DDG1 is expressed in various organs, especially in stems and panicles. Yeast two-hybrid assay, bimolecular fluorescent complementation and luciferase complementation image assay showed that More >

S. Deva Kumar, S. Venkatramaphanikumar^*, K. Venkata Krishna Kishore

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 1013-1032, 2023, DOI:10.32604/iasc.2023.038165 - 29 April 2023

Abstract Type 2 diabetes patients often suffer from microvascular complications of diabetes. These complications, in turn, often lead to vision impairment. Diabetic Retinopathy (DR) detection in its early stage can rescue people from long-term complications that could lead to permanent blindness. In this study, we propose a complex deep convolutional neural network architecture with an inception module for automated diagnosis of DR. The proposed novel Hybrid Inception U-Net (HIUNET) comprises various inception modules connected in the U-Net fashion using activation maximization and filter map to produce the image mask. First, inception blocks were used to enlarge… More >

Mohamed Ezz, Waad Alanazi, Ayman Mohamed Mostafa^*, Eslam Hamouda, Murtada K. Elbashir, Meshrif Alruily

Computer Systems Science and Engineering, Vol.46, No.2, pp. 2299-2317, 2023, DOI:10.32604/csse.2023.036567 - 09 February 2023

Abstract Palmprint identification has been conducted over the last two decades in many biometric systems. High-dimensional data with many uncorrelated and duplicated features remains difficult due to several computational complexity issues. This paper presents an interactive authentication approach based on deep learning and feature selection that supports Palmprint authentication. The proposed model has two stages of learning; the first stage is to transfer pre-trained VGG-16 of ImageNet to specific features based on the extraction model. The second stage involves the VGG-16 Palmprint feature extraction in the Siamese network to learn Palmprint similarity. The proposed model achieves More >

Ibrar Amin¹, Saima Hassan¹, Samir Brahim Belhaouari^2,*, Muhammad Hamza Azam³

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 6335-6349, 2023, DOI:10.32604/cmc.2023.033860 - 28 December 2022

Abstract Malaria is a lethal disease responsible for thousands of deaths worldwide every year. Manual methods of malaria diagnosis are time-consuming that require a great deal of human expertise and efforts. Computer-based automated diagnosis of diseases is progressively becoming popular. Although deep learning models show high performance in the medical field, it demands a large volume of data for training which is hard to acquire for medical problems. Similarly, labeling of medical images can be done with the help of medical experts only. Several recent studies have utilized deep learning models to develop efficient malaria diagnostic More >

Abdullah A. Asiri¹, Muhammad Aamir², Ahmad Shaf^2,*, Tariq Ali², Muhammad Zeeshan³, Muhammad Irfan⁴, Khalaf A. Alshamrani¹, Hassan A. Alshamrani¹, Fawaz F. Alqahtani¹, Ali H. D. Alshehri¹

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5735-5753, 2022, DOI:10.32604/cmc.2022.031747 - 28 July 2022

Abstract The precise brain tumor diagnosis is critical and shows a vital role in the medical support for treating tumor patients. Manual brain tumor segmentation for cancer analysis from many Magnetic Resonance Images (MRIs) created in medical practice is a problematic and timewasting task for experts. As a result, there is a critical necessity for more accurate computer-aided methods for early tumor detection. To remove this gap, we enhanced the computational power of a computer-aided system by proposing a fine-tuned Block-Wise Visual Geometry Group19 (BW-VGG19) architecture. In this method, a pre-trained VGG19 is fine-tuned with CNN More >