Yasser Bagheri1,2,3, Fateme Babaha4, Reza Falak1,2, Reza Yazdani3, Gholamreza Azizi5, Maryam Sadri1, Hassan Abolhassani3,6, Mehdi Shekarabi1,2, Asghar Aghamohammadi3
European Cytokine Network, Vol.30, No.3, pp. 107-113, 2019, DOI:10.1684/ ecn.2019.0434
Abstract Background: Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory
effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming
growth factor-beta (TGF-β) in the regulation of B cell class switching the production of immunoglobulin A (IgA);
however, the underlying mechanisms remain to be fully elucidated. The objective of this study was to investigate the
TGF-β response during B stimulation of human B cells by IL-10. Methods: Pan B cells of healthy donors were
negatively purified by a magnetic cell separation technique. B cells were cultured… More >