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Search Results (62)
  • Open Access

    ARTICLE

    Microglia and brain macrophages are differentially associated with tumor necrosis in glioblastoma: A link to tumor progression

    CHRISTINA LOH1, YUQI ZHENG1, ISLAM ALZOUBI2, KIMBERLEY L. ALEXANDER3,4, MAGGIE LEE4, WEI-DONG CAI2, YANG SONG5, KERRIE MCDONALD6, ANNA K. NOWAK7, RICHARD B. BANATI8,9, MANUEL B. GRAEBER1,4,10,*

    Oncology Research, Vol.33, No.4, pp. 937-950, 2025, DOI:10.32604/or.2024.056436 - 19 March 2025

    Abstract Background: Microglia and brain macrophages contribute significantly to the tumor microenvironment in highly malignant glioblastoma where they are considered important drivers of tumor progression. A better understanding of the role of the brain macrophages present in glioblastoma appears crucial for improving therapeutic outcomes, especially in the context of novel immunotherapeutic approaches. Methods: We investigated the regulation of two well-established markers for microglia and brain macrophages, IBA1 and CD163, in relation to glioblastoma tumor necrosis using immunohistochemistry and modality fusion heatmaps of whole slide images obtained from adjacent tissue sections. Results: IBA1 and CD163 showed remarkable differences… More >

  • Open Access

    ARTICLE

    Assessing the impact of CD73 inhibition on overcoming anti-EGFR resistance in glioma cells

    LUIZ FERNANDO LOPES SILVA1,#, JULIETE NATHALI SCHOLL1,#, AUGUSTO FERREIRA WEBER1, CAMILA KEHL DIAS1, PAULINE RAFAELA PIZZATO2, VINíCIUS PIERDONá LIMA1, JEAN SÉVIGNY3,4, ANA MARIA OLIVEIRA BATTASTINI1, FABRÍCIO FIGUEIRÓ1,2,*

    Oncology Research, Vol.33, No.4, pp. 951-964, 2025, DOI:10.32604/or.2024.055508 - 19 March 2025

    Abstract Objectives: Glioblastoma (GB) is a grade IV glial tumor characterized by high malignancy and dismal prognosis, primarily due to high recurrence rates and therapeutic resistance. The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), regulates signaling pathways, including cell growth, proliferation, survival, migration, and cell death. Many cancers utilize immune checkpoints (ICs) to attenuate immune responses. CD73 is an enzyme that functions as an IC by hydrolyzing AMP to adenosine, suppressing immune cells in the tumor microenvironment. However, the role of CD73 in resistance to EGFR inhibitors is poorly understood. This study aims… More >

  • Open Access

    ARTICLE

    Comprehensive analysis reveals PLK3 as a promising immune target and prognostic indicator in glioma

    TIANYUN ZHU1,2,#, CUNYAN ZHAO1,2,#, RUI GONG1,2, AO QIAN1, XIAOSHU WANG1, FANGHUI LU2, GANG HUO1, LIANGJUN QIAO3, SONG CHEN1,*

    Oncology Research, Vol.33, No.2, pp. 431-442, 2025, DOI:10.32604/or.2024.050794 - 16 January 2025

    Abstract Background: PLK3, which played an important role in cell cycle progression and stress response, was identified as highly expressed in various carcinomas. However, the functions, molecular characteristics, and prognostic value of PLK3 in glioma remained unexplored. Methods: We analyzed PLK3 expression in glioma samples from multiple databases. Both overexpression and knockdown of Plk3 were performed to investigate tumor cell growth in glioma, and the transplanted glioma mouse model demonstrated the role of Plk3 on tumor progression. Immunohistochemistry was conducted to detect PLK3 expression and immune cell infiltration. The trans-well assay for PLK3 on the immune… More >

  • Open Access

    ARTICLE

    A comprehensive and systematic analysis of Dihydrolipoamide S-acetyltransferase (DLAT) as a novel prognostic biomarker in pan-cancer and glioma

    HUI ZHOU#, ZHENGYU YU#, JING XU, ZHONGWANG WANG, YALI TAO, JINJIN WANG, PEIPEI YANG, JINRONG YANG*, TING NIU*

    Oncology Research, Vol.32, No.12, pp. 1903-1919, 2024, DOI:10.32604/or.2024.048138 - 13 November 2024

    Abstract Background: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase complex (PDC), a rate-limiting enzyme complex, that can participate in either glycolysis or the tricarboxylic acid cycle (TCA). However, the pathogenesis is not fully understood. We aimed to perform a more systematic and comprehensive analysis of DLAT in the occurrence and progression of tumors, and to investigate its function in patients’ prognosis and immunotherapy. Methods: The differential expression, diagnosis, prognosis, genetic and epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell analysis, and drug response across cancers were conducted based on multiple computational… More > Graphic Abstract

    A comprehensive and systematic analysis of Dihydrolipoamide S-acetyltransferase <i>(DLAT)</i> as a novel prognostic biomarker in pan-cancer and glioma

  • Open Access

    ARTICLE

    Using Multi-Omics Analysis to Explore Diagnostic Tool and Optimize Drug Therapy Selection for Patients with Glioma Based on Cross-Talk Gene Signature

    YUSHI YANG1,#, CHUJIAO HU2,#, SHAN LEI3, XIN BAO3, ZHIRUI ZENG3,*, WENPENG CAO4,*

    Oncology Research, Vol.32, No.12, pp. 1921-1934, 2024, DOI:10.32604/or.2024.046191 - 13 November 2024

    Abstract Background: The heterogeneity of prognosis and treatment benefits among patients with gliomas is due to tumor microenvironment characteristics. However, biomarkers that reflect microenvironmental characteristics and predict the prognosis of gliomas are limited. Therefore, we aimed to develop a model that can effectively predict prognosis, differentiate microenvironment signatures, and optimize drug selection for patients with glioma. Materials and Methods: The CIBERSORT algorithm, bulk sequencing analysis, and single-cell RNA (scRNA) analysis were employed to identify significant cross-talk genes between M2 macrophages and cancer cells in glioma tissues. A predictive model was constructed based on cross-talk gene expression, and… More >

  • Open Access

    ARTICLE

    ResMHA-Net: Enhancing Glioma Segmentation and Survival Prediction Using a Novel Deep Learning Framework

    Novsheena Rasool1,*, Javaid Iqbal Bhat1, Najib Ben Aoun2,3, Abdullah Alharthi4, Niyaz Ahmad Wani5, Vikram Chopra6, Muhammad Shahid Anwar7,*

    CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 885-909, 2024, DOI:10.32604/cmc.2024.055900 - 15 October 2024

    Abstract Gliomas are aggressive brain tumors known for their heterogeneity, unclear borders, and diverse locations on Magnetic Resonance Imaging (MRI) scans. These factors present significant challenges for MRI-based segmentation, a crucial step for effective treatment planning and monitoring of glioma progression. This study proposes a novel deep learning framework, ResNet Multi-Head Attention U-Net (ResMHA-Net), to address these challenges and enhance glioma segmentation accuracy. ResMHA-Net leverages the strengths of both residual blocks from the ResNet architecture and multi-head attention mechanisms. This powerful combination empowers the network to prioritize informative regions within the 3D MRI data and capture… More >

  • Open Access

    ARTICLE

    GliomaCNN: An Effective Lightweight CNN Model in Assessment of Classifying Brain Tumor from Magnetic Resonance Images Using Explainable AI

    Md. Atiqur Rahman1, Mustavi Ibne Masum1, Khan Md Hasib2, M. F. Mridha3,*, Sultan Alfarhood4, Mejdl Safran4,*, Dunren Che5

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2425-2448, 2024, DOI:10.32604/cmes.2024.050760 - 08 July 2024

    Abstract Brain tumors pose a significant threat to human lives and have gained increasing attention as the tenth leading cause of global mortality. This study addresses the pressing issue of brain tumor classification using Magnetic resonance imaging (MRI). It focuses on distinguishing between Low-Grade Gliomas (LGG) and High-Grade Gliomas (HGG). LGGs are benign and typically manageable with surgical resection, while HGGs are malignant and more aggressive. The research introduces an innovative custom convolutional neural network (CNN) model, Glioma-CNN. GliomaCNN stands out as a lightweight CNN model compared to its predecessors. The research utilized the BraTS 2020 More >

  • Open Access

    ARTICLE

    Revealing the role of honokiol in human glioma cells by RNA-seq analysis

    YUNBAO GUO1,#, XU LIU1,#, QI XU2, XIAOTONG ZHOU3, JIAWEI LIU3, YANYAN XU2, YAN LU2,*, HAIYAN LIU2,*

    BIOCELL, Vol.48, No.6, pp. 945-958, 2024, DOI:10.32604/biocell.2024.049748 - 10 June 2024

    Abstract Background: Glioma is a kind of tumor that easily deteriorates and originates from glial cells in nerve tissue. Honokiol is a bisphenol compound that is an essential monomeric compound extracted from the roots and bark of Magnoliaceae plants. It also has anti-infection, antitumor, and immunomodulatory effects. In this study, we found that honokiol induces cell apoptosis in the human glioma cell lines U87-MG and U251-MG. However, the mechanism through which honokiol regulates glioma cell apoptosis is still unknown. Methods: We performed RNA-seq analysis of U251-MG cells treated with honokiol and control cells. Protein-protein interaction (PPI)… More > Graphic Abstract

    Revealing the role of honokiol in human glioma cells by RNA-seq analysis

  • Open Access

    ARTICLE

    Bioinformatics comprehensive analysis confirmed the potential involvement of SLC22A1 in lower-grade glioma progression and prognosis

    JING HUI1,2, NANA SUN3, YONG LIU4, CHUNBO YU1,2, YONG KE4, YONG CAO4, ANXIAO YU4, QINGHONG KONG1,2,*, YUN LIU1,2,4,*

    BIOCELL, Vol.48, No.5, pp. 803-815, 2024, DOI:10.32604/biocell.2024.047122 - 06 May 2024

    Abstract Background: Although it has been established that the human Solute Carrier Family 22 (SLC22) functions as a cationic transporter, influencing cellular biological metabolism by modulating the uptake of various cations, its impact on cancer prognosis remains unclear. Methods: We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas (TCGA) and other databases to assess the prognostic value and functional implications across various tumors. Silence of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lower-grade glioma (LGG) progression. Results: Our findings demonstrated a significant correlation between SLC22A1 expression… More >

  • Open Access

    ARTICLE

    Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of GNAL in glioma

    ZHEN LIU1,#, LIANGWANG YANG2,#, ZHENGXING XIE1, HUI YU3, TIANYI GU3, DAOMING SHI4, NING CAI1,*, SHENGHUA ZHUO2,*

    Oncology Research, Vol.32, No.5, pp. 965-981, 2024, DOI:10.32604/or.2024.045769 - 23 April 2024

    Abstract Clinical data indicates that glioma patients have poor treatment outcomes and clinical prognosis. The role of olfactory signaling pathway-related genes (OSPRGs) in glioma has not been fully elucidated. In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid… More >

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