Jianlin Wang*1,
Wenjie Song*1,
Weiwei Shen†1,
Xisheng Yang*, Wei Sun*, Sshibin Qu*, Runze Shang*,
Ben Ma*, Meng Pu*, Kaishan Tao*, Kefeng Dou*, Haimin Li*
Oncology Research, Vol.27, No.2, pp. 281-282, 2019, DOI:10.3727/096504019X15476499940873
Abstract MicroRNA-200a (miR-200a) is frequently downregulated in most cancer types and plays an important role
in carcinogenesis and cancer progression. In this study, we determined that miR-200a was downregulated
in hepatocellular carcinoma (HCC) tissues and cell lines, consistent with the results of our previous study.
Because a previous study suggested that downregulation of miR-200a is correlated with HCC metastasis, we
aimed to elucidate the mechanism underlying the role of miR-200a in metastasis in HCC. Here we observed
that overexpression of miR-200a resulted in suppression of HCC metastatic ability, including HCC cell migration, invasion, and metastasis, in vitro and in vivo. Furthermore,… More >
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