FATEMEH HEIDARI^1,2, REIHANEH SEYEDEBRAHIMI^1,2, PIAO YANG³, MOHSEN ESLAMI FARSANI^1,2, SHIMA ABABZADEH^2,4, NASER KALHOR⁵, HAMED MANOOCHEHRI⁶, MOHSEN SHEYKHHASAN^7,*, MARYAM AZIMZADEH^8,9,*

BIOCELL, Vol.47, No.12, pp. 2597-2608, 2023, DOI:10.32604/biocell.2023.043351

Abstract Exosomes are small vesicles that carry molecules from one cell to another. They have many features that make them interesting for research, such as their stability, low immunogenicity, size of the nanoscale, toxicity, and selective delivery. Exosomes can also interact with viruses in diverse ways. Emerging research highlights the significant role of exosomes in viral infections, particularly in the context of diseases like COVID-19, HIV, HBV and HCV. Understanding the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral therapies. An important aspect is gaining clarity on how exosomes influence the… More >

YUE CAO, LIN HU, YISHU TANG^*

BIOCELL, Vol.47, No.7, pp. 1537-1548, 2023, DOI:10.32604/biocell.2023.027205

Abstract Backgrounds: Both hepatitis B virus X protein (HBx) and microRNA-221 (miR-221) have been implicated in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The present study demonstrates that HBx promotes HCC cell proliferation via the C-X-C motif chemokine ligand 12-C-X-C chemokine receptor type 4 (CXCL12-CXCR4) axis. We predict that HBx/miR-221-mediated CXCL12/CXCR4 signaling induces NKT cells to promote HBV-related HCC. Methods: After miR-221 mimic, miR-221 mimic negative control, miR-221 inhibitor, miR-221 inhibitor negative control were transfected into cells, the expression of CXCL12 and miR-221 was detected by qPCR and western blot. Then we constructed a stable HBV-HCC cell line.… More >

Sakda Noinang¹, Zulqurnain Sabir², Muhammad Asif Zahoor Raja³, Soheil Salahshour⁴, Wajaree Weera^5,*, Thongchai Botmart⁵

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 2575-2588, 2023, DOI:10.32604/cmc.2023.029046

Abstract The current investigations are presented to solve the fractional order HBV differential infection system (FO-HBV-DIS) with the response of antibody immune using the optimization based stochastic schemes of the Levenberg-Marquardt backpropagation (LMB) neural networks (NNs), i.e., LMBNNs. The FO-HBV-DIS with the response of antibody immune is categorized into five dynamics, healthy hepatocytes (H), capsids (D), infected hepatocytes (I), free virus (V) and antibodies (W). The investigations for three different FO variants have been tested numerically to solve the nonlinear FO-HBV-DIS. The data magnitudes are implemented 75% for training, 10% for certification and 15% for testing to solve the FO-HBV-DIS with… More >

TIANXING LIU¹, HONGYAN DIAO^2,*

BIOCELL, Vol.47, No.1, pp. 27-32, 2023, DOI:10.32604/biocell.2022.023568

Abstract Non-coding RNAs are speculated to exert important regulatory functions at the level of gene expression, oncogenesis, and many other pathologies. Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), and some studies have shown that the expression of non-coding RNAs has an assignable effect on the development of HBV-induced HCC. In this context, the functions and molecular mechanisms of the HBVinduced non-coding RNA expression in the development of hepatoma have attracted increasing attention. This review covers the progress in the exploration of the relationship between HBV-induced hepatoma and non-coding RNA expression, cataloging the recent reports about… More >

Qiaodong Xu¹, Songgang Gu¹, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan

Oncology Research, Vol.27, No.4, pp. 509-514, 2019, DOI:10.3727/096504018X15278771272963

Abstract Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear. This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis and lead to… More >

Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang

Oncology Research, Vol.27, No.4, pp. 449-458, 2019, DOI:10.3727/096504017X15016337254623

Abstract MicroRNAs, a class of endogenous noncoding RNAs, regulate gene expression at the posttranscriptional level and thus take part in multiple biological processes. An increasing number of miRNAs have been found to be dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR- 125a-5p was found to be obviously downregulated much more in hepatitis B virus (HBV)-related HCC. To investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells. The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and induced cell apoptosis. Furthermore, overexpression of miR-125a-5p could significantly decrease the… More >

Kahina Iggui^1,2,*, Mustapha Kaci¹, Mohamed Mahlous³, Nicolas Le Moigne⁴, Anne Bergeret⁴

Journal of Renewable Materials, Vol.7, No.9, pp. 807-820, 2019, DOI:10.32604/jrm.2019.06778

Abstract In this paper, the effects of gamma irradiation on Cast poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV/Cloisite 30B (C30B) (3 wt%) bionanocomposite prepared by melt compounding, were evaluated at various doses, i.e., 5, 15, 20, 50 and 100 kGy at room temperature in air. Changes in molecular weight, morphology and physical properties were investigated. The study showed that the main degradation mechanism occurring in gamma irradiation in both Cast PHBV and C-PHBV/3C30B bionanocomposite is chain scission, responsible for the decrease of molecular weight. Differential scanning calorimetry (DSC) data indicated a regular decrease in crystallization temperature, melting temperature and crystallinity index for all irradiated… More >

Kahina Iggui^1,2,*,†, Mustapha Kaci², Nicolas Le Moigne¹, Anne Bergeret¹

Journal of Renewable Materials, Vol.6, No.3, pp. 288-298, 2018, DOI:10.7569/JRM.2017.634184

Abstract The effects of accelerated photooxidation on the molecular weight and thermal and mechanical properties of Cast PHBV and PHBV/Cloisite 30B (3 wt%) bionanocomposites are investigated herein. Through size exclusion chromatography (SEC) analysis, a significant decrease in both weight and number average molecular weights was observed for all irradiated samples over time, resulting from the chain scission mechanism. Differential scanning calorimetry (DSC) data indicated a decrease in degree of crystallinity and melting temperature after UV exposure, with the appearance of double melting peaks related to the changes in the crystal structure of PHBV. Thermal stability, tensile and thermo-mechanical properties were also… More >

G. El hajj Sleiman¹, G. Colomines¹, R. Deterre¹, I. Petit1, E. Leroy², S. Belhabib^1,*

Journal of Renewable Materials, Vol.6, No.3, pp. 270-276, 2018, DOI:10.7569/JRM.2017.634179

Abstract Poly(3-hydroxy butyrate)-co-(3-hydroxy valerate) (PHBV) is a biobased and biodegradable polyester. This semicrystalline bioplastic could be a good candidate for the replacement of some commodity plastics derived from oil. However, the control of the conditions of its processing in order to obtain optimal properties of the finished products remains a current research subject. The objective of this work is to better understand the crystallization under injection molding conditions by inline measurements during the process. We focused on the influence of two key processing parameters, namely, mold temperature and packing pressure. The modeling of inline temperature measurements allowed an inverse estimation of… More >

Sudhakar Muniyasamy^1,2, Osei Ofosu^1,2, Maya Jacob John^1,2, Rajesh D. Anandjiwala^1,2*

Journal of Renewable Materials, Vol.4, No.2, pp. 133-145, 2016, DOI:10.7569/JRM.2016.634104

Abstract The present study investigates the mineralization of poly(lactic acid) (PLA) and poly(3-hydroxybutyrate-covalerate) (PHBV), and PLA/PHBV blend in compost and soil burial environments. The mineralization was assayed on the basis of carbon dioxide (CO2) release from the test materials incubated in compost and soil for a period of 200 days. The degradation was followed by means of fragmentation, thermogravimetric (TGA), FTIR spectroscopy and scanning electron microscopy (SEM) analyses. The results showed that PLA, PHBV and blend of PLA/PHBV achieved almost 90% biodegradation under composting conditions, while PHBV, PLA/PHBV blend and PLA respectively achieved only 35%, 32% and 4% biodegradation under soil… More >