Zhuwei Tao, Yanfeng He^*, Hui Xu^*, Shengda Zhang, Zetao Sun, Ying Wu, Peng Li, Xing Shi

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.8, 2026, DOI:10.32604/fdmp.2026.086018 - 04 September 2026

Abstract This study elucidates the mechanisms governing sand production during multi-thermal fluid huff-and-puff in unconsolidated sandstone heavy oil reservoirs and develops a temperature-pressure coupled prediction model for accurately quantifying sand production. Orthogonal laboratory experiments were conducted on reservoir samples from a representative case (Block X, Oilfield L), to compare the mechanical response and sand production behavior under multi-thermal fluid and conventional steam stimulation. The relative importance of the governing parameters was quantified using analysis of variance (ANOVA), and an exponential prediction model incorporating the coupled effects of temperature and pressure was established. The results reveal that… More >

Peng Guan^*, Ming-Ran Li, Si-Bo-Wen Wang

Frontiers in Heat and Mass Transfer, Vol.24, No.4, 2026, DOI:10.32604/fhmt.2026.082595 - 31 August 2026

Abstract This paper develops a thermomechanical optimization method for turbo guide vane (TGV) weight reduction under restrictive conditions and highly sensitive variables. The proposed method integrates a flow-thermo-structural model, orthogonal experimental design (OED), and an optimization framework based on response surface methodology (RSM) and a genetic algorithm (GA). To address both the plastic limit and temperature distribution of the TGV, a new parameter termed the stress ratio is introduced as a constraint during optimization. Six highly sensitive variables were selected from ten cooling channel diameters using OED. Simulation results based on the thermal-fluid coupling model were… More >

Shunran Duan, Meijuan Yin^*, Xiangyang Luo, Lunchong Cui, Chenyu Wang

CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.084290 - 13 August 2026

Abstract Few-shot relation classification aims to identify semantic relations between entity pairs under limited annotated data. Although recent prompt learning-based methods have achieved promising performance, they often rely on manually crafted, domain-specific prompt templates, which restrict their transferability across domains. In this paper, building upon the multi-task prompt transfer paradigm of MPT, we propose a Confidence-guided Orthogonality-constraint Prompt Adaptation framework for few-shot relation classification, named COPA. The proposed framework learns a shared domain-invariant prompt matrix together with domain-specific low-rank prompt matrices via multi-domain soft prompt tuning, enabling the transfer of domain-invariant relational knowledge across domains. Unlike… More >

Yanhong Wang^1,#, Junbo Liu^2,#, Qiaoping Xu^3,#, Zhao Ma^4,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.082432 - 13 August 2026

Abstract In renal cell carcinoma (RCC), alterations in cellular metabolism are a defining feature, among which impaired mitochondrial function stands out as a key factor influencing both tumor aggressiveness and patient responses to therapy. The aim of this review is to systematically synthesize current knowledge on the role of mitochondrial dysfunction in RCC pathogenesis and to explore emerging therapeutic strategies targeting mitochondrial vulnerabilities. This comprehensive analysis examines the integrated dysregulation of core mitochondrial processes—bioenergetic metabolism, organelle dynamics, programmed cell death pathways, redox homeostasis, and selective autophagy—in driving RCC pathogenesis. Our synthesis reveals how genetic drivers, molecular… More >

Ikenna D. Arungwa^1,2,*, Elochukwu C. Moka²

Revue Internationale de Géomatique, Vol.35, pp. 423-459, 2026, DOI:10.32604/rig.2026.083164 - 29 July 2026

Abstract This study utilized nearly two decades of temporal gravity field observations from the Gravity Recovery and Climate Experiment (GRACE/GRACE-FO) satellite missions to analyze the spatial and temporal variations of terrestrial water storage (TWS) and groundwater storage (GWS) in Nigeria. Advanced statistical techniques, including Singular Spectrum Analysis (SSA), Principal Component Analysis (PCA), and Empirical Orthogonal Function (EOF), were applied to characterize and quantify these variations at a basin scale. Results show that TWS exhibits biennial, annual seasonal fluctuations (between ±10 to ±55 mm), reaching its lowest levels during the dry season (February–June) and peaking in the… More >

Ali Raza^1,*, Umar Shafique¹, Marek Lampart¹, Dumitru Baleanu², Emad Fadhal³, Hadil Alhazmi⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.148, No.1, 2026, DOI:10.32604/cmes.2026.084939 - 27 July 2026

Abstract Kawasaki disease (KD) is an acute, self-limited pediatric vasculitis of unknown etiology and is one of the leading causes of acquired coronary artery complications in children. Endothelial dysfunction, vascular endothelial growth factor (VEGF) activity, adhesion molecule/chemokine activation, and inflammatory cytokine responses play important roles in its pathogenesis. This paper presents a delay differential equation model with stochastic perturbations to study lesion-level inflammatory mechanisms involved in Kawasaki disease pathogenesis. The model describes interactions among healthy endothelial cells, vascular endothelial growth factor (VEGF), adhesion molecules/chemokines, and inflammatory cytokine activity. Mathematically, endothelial-cell injury promotes VEGF production, VEGF contributes… More >

Laura Schaltz^1,2, Simon Lassnig^1,2, Karola Schlote^1,2, Christian Schwerk³, Horst Schroten³, Nicole de Buhr^1,2,*

BIOCELL, Vol.50, No.8, 2026, DOI:10.32604/biocell.2026.079046 - 27 July 2026

Abstract Objectives: Streptococcus suis (S. suis) is a worldwide occurring pathogen in pigs and humans that can cross the blood-cerebrospinal fluid barrier (BCSFB) to cause meningitis, while host neutrophils counter infection through mechanisms including the release of neutrophil extracellular traps (NETs). NET-formation involves the release of nuclear DNA with antimicrobial components, which can bind and kill bacteria. We aimed to characterize the host-pathogen interaction between S. suis and neutrophils within the CSF compartment, focusing on NET-formation. Methods: A 3D cell culture model of the porcine BCSFB was used by cultivating a porcine choroid plexus epithelial cell line (PCP-R) on filter… More >

Jiamei Wu^1,*, Yuechuan Zhang², Junxue Wu², Chengxin Hao¹

BIOCELL, Vol.50, No.7, 2026, DOI:10.32604/biocell.2026.071704 - 29 June 2026

Abstract Enterovirus 71 (EV71), a member of the family Picornaviridae, genus Enterovirus, is an agent of hand, foot, and mouth disease (HFMD) and remains a persistent global health concern, particularly among children under five years of age. Although most infections are self-limiting, a significant proportion can progress to severe neurological manifestations such as aseptic meningitis, encephalitis, and fatal pulmonary oedema. Despite substantial advances in research, no universally effective antiviral therapy or broadly protective vaccine has yet been developed. Drawing upon both foundational and recent studies, we evaluate the strength of existing evidence and delineate how these viral… More >

Zhengzheng Li^1,2,#, Haitong Xie^1,2,#, Yujuan Chen^1,2, Qiuyan Li³, Xing Yuan⁴, Xinyue Dai³, Jie Chen^1,2,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081209 - 16 June 2026

Abstract Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies. Phosphoglycerate kinase 1 (PGK1) drives TNBC progression, but mechanisms governing its protein stability remain unclear. This study aims to identify the E3 ubiquitin ligase responsible for PGK1 degradation and evaluate its therapeutic potential against metastasis. Methods: Clinical datasets and 50 human TNBC tissues were analyzed via multiplex immunohistochemistry. Co-immunoprecipitation, ubiquitination linkage assays, and structural modeling were utilized for in vitro mechanistic studies in TNBC cells. Additionally, functional impacts on epithelial-mesenchymal transition (EMT) and metastasis were evaluated using transwell assays and an in vivo mouse lung metastasis… More >

Chaoshuai Duan, Yin Wang, Guohua Zhu^*, Xiaotian Zhang, Jiale Wang, Zhen Wang

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.081676 - 27 May 2026

Abstract Hybrid fiber reinforced plastic (HFRP) composites, especially intra-layer carbon/glass hybrids, offer a promising balance of specific strength, impact resistance, and cost efficiency for thin-walled energy-absorbing structures. This study investigates the low-velocity impact response and energy absorption of intra-layer carbon/glass hybrid hat-shaped beams. Tensile and impact tests evaluated the effects of hybrid ratio and fiber orientation. A multiscale damage model based on micromechanical damage and failure criteria was established via Abaqus/VUMAT, integrating stress amplification factors to bridge micro-meso-macro scales. Experimental results show that carbon fibers aligned with the loading direction yield hybrid composites with superior tensile… More >