Ali Raza^1,*, Umar Shafique¹, Marek Lampart¹, Dumitru Baleanu², Emad Fadhal³, Hadil Alhazmi⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.148, No.1, 2026, DOI:10.32604/cmes.2026.084939 - 27 July 2026

Abstract Kawasaki disease (KD) is an acute, self-limited pediatric vasculitis of unknown etiology and is one of the leading causes of acquired coronary artery complications in children. Endothelial dysfunction, vascular endothelial growth factor (VEGF) activity, adhesion molecule/chemokine activation, and inflammatory cytokine responses play important roles in its pathogenesis. This paper presents a delay differential equation model with stochastic perturbations to study lesion-level inflammatory mechanisms involved in Kawasaki disease pathogenesis. The model describes interactions among healthy endothelial cells, vascular endothelial growth factor (VEGF), adhesion molecules/chemokines, and inflammatory cytokine activity. Mathematically, endothelial-cell injury promotes VEGF production, VEGF contributes… More >

Laura Schaltz^1,2, Simon Lassnig^1,2, Karola Schlote^1,2, Christian Schwerk³, Horst Schroten³, Nicole de Buhr^1,2,*

BIOCELL, Vol.50, No.8, 2026, DOI:10.32604/biocell.2026.079046 - 27 July 2026

Abstract Objectives: Streptococcus suis (S. suis) is a worldwide occurring pathogen in pigs and humans that can cross the blood-cerebrospinal fluid barrier (BCSFB) to cause meningitis, while host neutrophils counter infection through mechanisms including the release of neutrophil extracellular traps (NETs). NET-formation involves the release of nuclear DNA with antimicrobial components, which can bind and kill bacteria. We aimed to characterize the host-pathogen interaction between S. suis and neutrophils within the CSF compartment, focusing on NET-formation. Methods: A 3D cell culture model of the porcine BCSFB was used by cultivating a porcine choroid plexus epithelial cell line (PCP-R) on filter… More >

Jiamei Wu^1,*, Yuechuan Zhang², Junxue Wu², Chengxin Hao¹

BIOCELL, Vol.50, No.7, 2026, DOI:10.32604/biocell.2026.071704 - 29 June 2026

Abstract Enterovirus 71 (EV71), a member of the family Picornaviridae, genus Enterovirus, is an agent of hand, foot, and mouth disease (HFMD) and remains a persistent global health concern, particularly among children under five years of age. Although most infections are self-limiting, a significant proportion can progress to severe neurological manifestations such as aseptic meningitis, encephalitis, and fatal pulmonary oedema. Despite substantial advances in research, no universally effective antiviral therapy or broadly protective vaccine has yet been developed. Drawing upon both foundational and recent studies, we evaluate the strength of existing evidence and delineate how these viral… More >

Zhengzheng Li^1,2,#, Haitong Xie^1,2,#, Yujuan Chen^1,2, Qiuyan Li³, Xing Yuan⁴, Xinyue Dai³, Jie Chen^1,2,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081209 - 16 June 2026

Abstract Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies. Phosphoglycerate kinase 1 (PGK1) drives TNBC progression, but mechanisms governing its protein stability remain unclear. This study aims to identify the E3 ubiquitin ligase responsible for PGK1 degradation and evaluate its therapeutic potential against metastasis. Methods: Clinical datasets and 50 human TNBC tissues were analyzed via multiplex immunohistochemistry. Co-immunoprecipitation, ubiquitination linkage assays, and structural modeling were utilized for in vitro mechanistic studies in TNBC cells. Additionally, functional impacts on epithelial-mesenchymal transition (EMT) and metastasis were evaluated using transwell assays and an in vivo mouse lung metastasis… More >

Chaoshuai Duan, Yin Wang, Guohua Zhu^*, Xiaotian Zhang, Jiale Wang, Zhen Wang

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.081676 - 27 May 2026

Abstract Hybrid fiber reinforced plastic (HFRP) composites, especially intra-layer carbon/glass hybrids, offer a promising balance of specific strength, impact resistance, and cost efficiency for thin-walled energy-absorbing structures. This study investigates the low-velocity impact response and energy absorption of intra-layer carbon/glass hybrid hat-shaped beams. Tensile and impact tests evaluated the effects of hybrid ratio and fiber orientation. A multiscale damage model based on micromechanical damage and failure criteria was established via Abaqus/VUMAT, integrating stress amplification factors to bridge micro-meso-macro scales. Experimental results show that carbon fibers aligned with the loading direction yield hybrid composites with superior tensile… More >

Peng Wang^1,2, Zhiying Gao^1,2,*, Yongyan Chen¹, Rina Su^1,2, Yefei Bai², Jianlong Ma^1,2, Tianhao Zhang¹

Energy Engineering, Vol.123, No.6, 2026, DOI:10.32604/ee.2025.073862 - 27 May 2026

Abstract We propose a novel procedure, Time-Domain De-Dopplerized Orthogonal Matching Pursuit deconvolution approach for the mapping of acoustic sources (TD-OMP-DAMAS), for separating aerodynamic noise sources distributed across wind turbine blades (WTB), a task that is typically hindered by mutual interference and spatial mixing. The proposed procedure is a two-stage, hybrid de-Doppler/sparse-reconstruction algorithm based on time-domain de-Doppler (TD, Stage 1) and an orthogonal matching pursuit (OMP)-based deconvolution scheme (Stage 2), enabling sparse-reconstruction techniques to be effectively applied in rotating-source scenarios. The method is validated using both simulated rotating-source data and wind-tunnel measurements, and its performance is systematically… More >

Dat Quoc Tran¹, Mayu Takeda², Eiji Sugihara², Tetsuya Tsukamoto^2,3, Yasushi Hoshikawa⁴, Yasuyoshi Mizutani¹, Kazuya Shiogama⁵, Naoya Asai⁶, Atsuko Niimi¹, Makoto Sumitomo², Hideyuki Saya², Motoshi Suzuki^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078309 - 21 May 2026

Abstract Objectives: Genetic risk models have substantially advanced our understanding of germline pathogenic variants (GPVs) in some malignancies, whereas their clinical significance in lung cancer remains unclear. The present study aimed to better understand potential contribution of GPVs to lung cancer etiology. Methods: A targeted sequencing panel of 143 cancer-related genes was applied to analyze 26 distinct lung adenocarcinoma (LUAD) tumors from 11 patients histopathologically diagnosed with multiple primary lung cancers (MPLC). Tumor classification was performed through integrated evaluation of mutation profiles, and variants shared among tumor lesions were further validated as likely germline or somatic mutations… More >

Zongchuan Li, Chen Sun^*, Jian Shu

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.079214 - 08 May 2026

Abstract This paper investigates the joint resource allocation problem in Reconfigurable Intelligent Surface (RIS)-assisted cooperative non-orthogonal multiple access device-to-device (CNOMA-D2D) cellular networks. To tackle the high-dimensional non-convex joint optimization of power control, RIS phase configuration and channel assignment, we propose an integrated user pairing strategy, PIP-UP, quantifying utility through factors, phase alignment, interference suppression and power difference, neglected in existing methods. Furthermore, we develop a hybrid deep reinforcement learning algorithm, A3TD, combining the parallel exploration capability of Asynchronous Advantage Actor-Critic (A3C) with the stable continuous optimization of Twin Delayed Deep Deterministic Policy Gradient (TD3). This integration More >

Zhihua Xiong, Xiaoling Liu^*, Yinfeng Wang

Structural Durability & Health Monitoring, Vol.20, No.2, 2026, DOI:10.32604/sdhm.2025.074619 - 31 March 2026

Abstract Autonomous truck platooning, as a novel transportation mode, has attracted significant attention due to its potential to improve transportation efficiency, reduce energy consumption, and lower operational costs. However, this emerging mode poses new challenges to the dynamic performance of long-span bridges. This study aims to investigate the impact of autonomous truck platoons on the dynamic performance of continuous beam bridges. Using finite element software to construct accurate vehicle-bridge interaction models, we simulated the dynamic response between vehicle platoons and bridge structures. The study systematically evaluated the effects of four key factors—vehicle speed, number of formations,… More >

Rong Guo^1,2,3,*, Jie Xiao^1,2, Xuehan Wang⁴, Qi Jiang^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.3, 2026, DOI:10.32604/fdmp.2026.077602 - 31 March 2026

Abstract To simultaneously reduce flow-induced noise and enhance hydraulic performance in centrifugal pumps, this study proposes a bionic volute tongue inspired by the serrated trailing-edge morphology of the long-eared owl wing. Hydraulic performance and volute-induced noise are integrated into a unified evaluation framework, enabling multi-objective optimization of the tongue geometry. An orthogonal experimental design coupled with Computational Fluid Dynamics (CFD) and Computational Fluid Acoustics (CFA) is employed to systematically assess the influence of serration parameters. A matrix-based decision method is then used to identify the optimal configuration balancing efficiency, head, and acoustic performance. The optimized design… More > Graphic Abstract