Isra Mohammed¹, Mohamed Elhafiz M. Musa², Murtada K. Elbashir^3,*, Ayman Mohamed Mostafa³, Amin Ibrahim Adam⁴, Mahmood A. Mahmood³, Areeg S. Faggad⁵

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3749-3763, 2025, DOI:10.32604/cmc.2025.063880 - 03 July 2025

Abstract Sonic Hedgehog Medulloblastoma (SHH-MB) is one of the four primary molecular subgroups of Medulloblastoma. It is estimated to be responsible for nearly one-third of all MB cases. Using transcriptomic and DNA methylation profiling techniques, new developments in this field determined four molecular subtypes for SHH-MB. SHH-MB subtypes show distinct DNA methylation patterns that allow their discrimination from overlapping subtypes and predict clinical outcomes. Class overlapping occurs when two or more classes share common features, making it difficult to distinguish them as separate. Using the DNA methylation dataset, a novel classification technique is presented to address… More >

Indu Bala^*, Wathsala Karunarathne, Lewis Mitchell

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 727-744, 2025, DOI:10.32604/cmc.2025.065706 - 09 June 2025

Abstract Recent advancements in computational and database technologies have led to the exponential growth of large-scale medical datasets, significantly increasing data complexity and dimensionality in medical diagnostics. Efficient feature selection methods are critical for improving diagnostic accuracy, reducing computational costs, and enhancing the interpretability of predictive models. Particle Swarm Optimization (PSO), a widely used metaheuristic inspired by swarm intelligence, has shown considerable promise in feature selection tasks. However, conventional PSO often suffers from premature convergence and limited exploration capabilities, particularly in high-dimensional spaces. To overcome these limitations, this study proposes an enhanced PSO framework incorporating Orthogonal… More >

Fengxia Shi^1,2, Pengcheng Wang^1,*, Haonan Zhan¹, Xiangyun Shi¹

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.5, pp. 1221-1238, 2025, DOI:10.32604/fdmp.2025.062244 - 30 May 2025

Abstract To investigate the impact of guide vane geometry—specifically, outlet angle, blade count, and radial height—on the performance of a Pump as Turbine (PAT), radial guide vanes were introduced upstream of the impeller in an IS80-50-315 low-specific-speed centrifugal PAT. Using an orthogonal test design, numerical simulations were conducted on 16 different PAT configurations, and the influence of vane geometry on performance was analyzed through a range analysis to determine the optimal parameter combinations. The results indicate that the number of guide vane blades significantly affects both the hydraulic efficiency and water head of the PAT under More >

Sajid Ali^*, Yong-Sun Moon^*

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1419-1451, 2025, DOI:10.32604/phyton.2025.064284 - 29 May 2025

Abstract This review focused on the role of plant growth-promoting rhizobacteria (PGPR) in enhancing plant growth and protecting against pathogens, highlighting their mechanisms of action, ecological benefits, and challenges. PGPR mediate plant growth through several mechanisms, including nutrient acquisition, production of antimicrobial compounds and induction of systemic resistance. These mechanisms are critical in improving crop yields, especially under stressful conditions. This review examines the molecular mechanisms of PGPR-mediated plant pathogen control, cellular mechanisms of PGPR in plant pathogen control, ecological and environmental benefits of PGPR application. Despite their potential, PGPR application is limited by environmental variability,… More >

CARLOS ALFONSO FLORES-GUTIéRREZ¹, ERANDIS DHENI TORRES-SáNCHEZ¹, EMMANUEL REYES-URIBE¹, JUAN HERIBERTO TORRES-JASSO², JOEL SALAZAR-FLORES^1,*

BIOCELL, Vol.49, No.5, pp. 767-787, 2025, DOI:10.32604/biocell.2025.062225 - 27 May 2025

Abstract Pesticides are chemical substances used to eliminate various pests. Currently, more than two million tons of pesticides are used annually in developing and developed countries. One of the chronic diseases associated with pesticide poisoning is diabetes. This review aimed to elucidate the mechanisms of action involved in the development of diabetes after pesticide poisoning. Relevant information was collected between January and May 2024, using databases such as PubMed, Google Academic, and Elsevier. Pesticides reduce the secretion of glucagon-like peptide-1 (GLP-1) in the intestine, thereby decreasing the release of insulin. Moreover, pesticides are metabolized to acetic More >

Huiru Cao¹, Shaoxin Li², Xiaomin Li^3,*, Yongxin Liu⁴

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 5575-5593, 2025, DOI:10.32604/cmc.2025.061954 - 19 May 2025

Abstract Efficient flight path design for unmanned aerial vehicles (UAVs) in urban environmental event monitoring remains a critical challenge, particularly in prioritizing high-risk zones within complex urban landscapes. Current UAV path planning methodologies often inadequately account for environmental risk factors and exhibit limitations in balancing global and local optimization efficiency. To address these gaps, this study proposes a hybrid path planning framework integrating an improved Ant Colony Optimization (ACO) algorithm with an Orthogonal Jump Point Search (OJPS) algorithm. Firstly, a two-dimensional grid model is constructed to simulate urban environments, with key monitoring nodes selected based on… More >

Wei Dong^1,2,3,4, Fuping Qian^5,*, Gang Li^1,*, Shi’an Zhou⁵, Lei Ding^2,4, Qingda Gao⁵, Xuemin Zeng¹

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.4, pp. 833-849, 2025, DOI:10.32604/fdmp.2024.056060 - 06 May 2025

Abstract Nitrogen oxides (NO_x) and particulate matter (PM) present significant risks to both human health and environmental sustainability. The Integrated Dust Removal and Denitrification Technology (DRDt) offers a more efficient and cost-effective solution for achieving ultralow industrial flue gas emissions; however, its effectiveness is undermined by low catalyst load rates and poor stability in filter materials. This study addresses these limitations by modifying conventional PTFE filter media (PTFE-Tim) through the incorporation of sodium alginate (SA) and dopamine (DA) as modifiers, resulting in two new filter materials: PTFE–SA–MOF and PTFE–DA–MOF. By optimizing the parameters of an orthogonal experimental… More >

Ahmed Mahmoud Ismail^1,2,*, Khalid Alhudaib¹, Donato Magistà^3,4

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 679-693, 2025, DOI:10.32604/phyton.2025.062196 - 31 March 2025

Abstract Coffee wilt represents one of the most devastating diseases of Arabica coffee (Coffea arabica L.) plantations in the primary coffee-producing regions. In this study, coffee trees manifesting wilt symptoms accompanied by the defoliation and drying of the whole tree were observed in the Jazan, El Baha, Najran, and Asir regions. The purpose of this investigation was to isolate and identify the Fusarium species recovered from symptomatic coffee trees. The developed fungi were initially characterized based on their morphological features followed by molecular phylogenetic multi-locus analysis of the combined sequences of ITS, TEF1-α, RPB2, and CaM. Twenty-five isolates… More >

Aihua Tao¹, Chao Li¹, Zhijun Jie¹, Yong Zhang¹, Xing Chen¹, Weili Liu^2,3,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.3, pp. 645-656, 2025, DOI:10.32604/fdmp.2025.059545 - 01 April 2025

Abstract Hydraulic sandblasting perforation plays a crucial role in the fracturing and reconstruction of unconventional oil and gas reservoirs. The jet nozzle is an essential part of the hydraulic perforation tool. Insufficient penetration depth, caused by excessive jet distances, presents challenges during the perforation process. To overcome this, an optimization design of the nozzle structure is required to enhance the perforation efficiency. In this paper, a computational fluid-dynamic model for conical-cylindrical nozzles has been elaborated. To further improve the rock-breaking efficiency of the jet nozzle, a fillet design is introduced at the nozzle inlet section. The… More >

Amine Batbat^1,2, Mohamed El Fadili³, Naoufal El Hachlafi^4,*, Amine Elbouzidi^5,*, Chaymae Hmimen⁶, Hiba Yahyaoui^2,7, Samir Jeddi⁶, Abdellatif Benbouazza², Kawtar Fikri-Benbrahim⁶, Mohamed Addi⁵, Samiah Hamad Al-Mijalli⁸, Khaoula Habbadi², Hassane Greche¹

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 481-501, 2025, DOI:10.32604/phyton.2025.059841 - 06 March 2025

Abstract This study highlights the regulatory potential antibacterial and antiradical of Origanum elongatum essential oil (EO), an endemic medicinal plant of Morocco used for its various properties. The chemical composition of the EO was characterized using gas chromatography-mass spectrometry (GC-MS). The antibacterial activity against different agricultural phytopathogens was determined by disc diffusion and microatmosphere methods, as well as by the determination of minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC), while the antioxidant activity was evaluated by DPPH and FRAP assays. To complement the experimental analyses, a molecular docking approach was used to predict and elucidate… More >