Shazia Rehman^1,2, Erum Rehman^3,*, Mehmood Ahmad⁴

International Journal of Mental Health Promotion, Vol.27, No.6, pp. 823-843, 2025, DOI:10.32604/ijmhp.2025.063582 - 30 June 2025

Abstract Objectives: Emotional exhaustion among healthcare professionals, particularly pharmacists, significantly impacts their well-being and efficacy in patient care. Understanding the psychological mechanisms contributing to emotional exhaustion is essential for developing effective interventions. The present research sought to investigate the potential mediating roles of rumination and coping strategies (adaptive and maladaptive) in the relationship between perceived stress and emotional exhaustion among pharmacists. Methods: A cross-sectional survey was carried out between September 2023 and January 2024 involving 576 pharmacists working in public hospitals in Punjab who met the inclusion criteria and actively participated in the study. We employed… More >

Yuhe Wang^1,2, Haijun Sun³, Yaqiong Hao^2,4, Xiancan Zhu¹, Ju Min^2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.6, pp. 1735-1750, 2025, DOI:10.32604/phyton.2025.063868 - 27 June 2025

Abstract Over the past three decades, the expansion of intensive vegetable farming in southern China has led to excessive nitrogen (N) and phosphorus (P) fertilizer application, causing substantial N and P runoff losses. This study investigated four major vegetable production regions in southern China—the upper reaches of the Yangtze River (U-YR), the middle lower reaches of the Yangtze River (ML-YR), the Southeast Coast (SC), and the Pearl River basin (PR)—analyzing 175 published articles to characterize spatiotemporal patterns of N and P fertilizer applications and associated runoff losses from 1992 to 2021. The result showed that the… More >

JIANMIAO YANG^1,2,#, XIAOYAN SUN^3,#, TIANTIAN WANG¹, HAIQING ZHONG^1,3, MIN HAN^1,3, WUPING SHUAI^4,5,6,*, DONGHANG XU^1,*

Oncology Research, Vol.33, No.6, pp. 1423-1436, 2025, DOI:10.32604/or.2025.058997 - 29 May 2025

Abstract Objectives: Triphenylphosphine (TPP) and Doxorubicin (DOX) were conjugated to obtain Triphenylphosphine-Doxorubicin (TPP-DOX), which was applied in tumor cells for enhancement of DOX in mitochondria targeting. The study focused on investigating the anti-tumor effect of TPP-DOX in combination with radiotherapy throughout in vitro and in vivo studies. Methods: TPP-DOX was synthesized using the carbodiimide method. In vitro experiments were conducted with 4T1 cells (mouse breast cancer cell line) to assess apoptosis induction, mitochondrial targeting, reactive oxygen species (ROS) production, and mitochondrial membrane potential. The research evaluates the effects of TPP-DOX, DOX, and their combinations with radiotherapy. A nude mouse… More > Graphic Abstract

Qi Guo¹, Jianxiong Xu^2,*, Xuan Cai², Jiaojiao Xie¹, Siqi Wu¹

BIOCELL, Vol.49, No.5, pp. 907-924, 2025, DOI:10.32604/biocell.2025.063568 - 27 May 2025

Abstract Objectives: Weaning induces oxidative stress in pigs, increasing the risk of diarrhea and death. Intestinal damage is associated with obstructed intestinal cell cycles. To stop damage caused by reactive oxygen species (ROS), N-acetyl cysteine (NAC) has been widely employed. In this study, we examined changes in the intestinal cyclin of weaning piglets and assessed the impact of NAC on intestinal cell cycle arrest and intracellular signaling pathways. Methods: We conducted two animal experiments. In the first, we divided 12 litters of 120 newborn piglets into two groups: a control group and a weaning group. The… More >

He Su, Jianwei Gao, Kang Kong^*

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 4193-4213, 2025, DOI:10.32604/cmc.2025.063355 - 19 May 2025

Abstract Accurate and robust navigation in complex surgical environments is crucial for bronchoscopic surgeries. This study purposes a bronchoscopic lumen feature matching network (BLFM-Net) based on deep learning to address the challenges of image noise, anatomical complexity, and the stringent real-time requirements. The BLFM-Net enhances bronchoscopic image processing by integrating several functional modules. The FFA-Net preprocessing module mitigates image fogging and improves visual clarity for subsequent processing. The feature extraction module derives multi-dimensional features, such as centroids, area, and shape descriptors, from dehazed images. The Faster R-CNN Object detection module detects bronchial regions of interest and… More >

Melissa Mashaba¹, Curwyn Mapaling^2,*, Wandile F. Tsabedze³

Journal of Psychology in Africa, Vol.35, No.1, pp. 29-35, 2025, DOI:10.32604/jpa.2025.066007 - 30 April 2025

Abstract The coronavirus disease (COVID-19) pandemic introduced significant psychosocial stressors for morticians in South Africa, yet their coping mechanisms remain underexplored. This study investigated how South African morticians (N = 10, Black males) coped with these stressors during the pandemic through semi-structured interviews. Interpretative phenomenological analysis (IPA) informed thematic analysis identified five themes: (i) death overload distress associated with trauma and fear of exposure; (ii) insomnia due to worry, workload, and fear of infection; (iii) stigmatisation from community avoidance and negative perceptions; (iv) social isolation and anxiety related to emotional disconnection, personal protective equipment (PPE) shortages, More >

Jung-Il Chae^1,#, Ji-Hye Seo^1,#, Goo Yoon², Young-Joo Jeon^3,*, Woo-Keun Kim^4,*

BIOCELL, Vol.49, No.4, pp. 647-663, 2025, DOI:10.32604/biocell.2025.062137 - 30 April 2025

Abstract Background: Picropodophllotoxin (PPT), a principal component of Podophyllum hexandrum root, demonstrates various beneficial biological activities in multiple cancer types, including antitumor and antiproliferative properties. Despite its known effects, the specific mechanisms by which PPT induces apoptosis in oral squamous cell carcinoma (OSCC) cells lack full clarification. Aims: This study aimed to evaluate the role of PPT in inducing apoptosis in OSCC cells by targeting signal transducer and activator of transcription 3 (STAT3) and to investigate the underlying molecular pathways. Methods: Human OSCC cell lines (HN22 and HSC4) were treated with PPT. Cell viability, colony formation, and apoptotic… More >

Qing Wang, Luyao Cai, Shouyi Tang, Dan Pan, Zhen Wang, Qianming Chen, Yu Zhou^*, Yingqiang Shen^*

BIOCELL, Vol.49, No.4, pp. 579-605, 2025, DOI:10.32604/biocell.2025.060045 - 30 April 2025

Abstract Cancer Stem Cells (CSCs) are cancer cells with self-renewal and tumorigenesis abilities. CSCs in tumor tissues are the leading cause of tumor progression, recurrence, and drug resistance. CSCs have distinct metabolic features that contribute to maintaining their self-renewal and stemness. Phospholipids are essential components of cell membranes and play fundamental roles in cellular activities. CSCs have abnormal phospholipid metabolism, which affects their self-renewal, differentiation, invasion, and drug resistance. Compared with non-CSCs, the phospholipid metabolism of CSCs mainly focused on significantly increased fatty acid (FAs) and phospholipids synthesis, phospholipid unsaturation, and lipolysis-fatty acid oxidation (FAO). In More > Graphic Abstract

Pikkili Gopala Krishna^1,*, Jalari Somasekar²

Intelligent Automation & Soft Computing, Vol.40, pp. 235-259, 2025, DOI:10.32604/iasc.2025.063657 - 28 April 2025

Abstract Stress is mental tension caused by difficult situations, often experienced by hospital workers and IT professionals who work long hours. It is essential to detect the stress in shift workers to improve their health. However, existing models measure stress with physiological signals such as PPG, EDA, and blink data, which could not identify the stress level accurately. Additionally, the works face challenges with limited data, inefficient spatial relationships, security issues with health data, and long-range temporal dependencies. In this paper, we have developed a federated learning-based stress detection system for IT and hospital workers, integrating… More >

Michela Costa^1,*, Adolfo Palombo², Andrea Ricci², Ugo Sorge³

Energy Engineering, Vol.122, No.5, pp. 1629-1643, 2025, DOI:10.32604/ee.2025.062613 - 25 April 2025

Abstract Effective thermal management is paramount for successfully deploying lithium-ion batteries in residential settings as storage systems for the exploitation of renewable sources. Uncontrolled temperature increases within battery packs can lead to critical issues such as cell overheating, potentially culminating in thermal runaway events and, in extreme cases, leading to fire or explosions. This work presents a comprehensive numerical thermal model of a battery pack made of prototype pouch cells based on lithium ferrophosphate (LFP) chemistry. The multi-physical model is specifically developed to investigate real-world operating scenarios and to assess safety considerations. The considered energy storage… More >