Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

Yuang Chen^1,2, Yong Li^1,*, Fang Lin^1,2, Shuhan Lv^1,2, Jiaze Jiang^1,2

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-18, 2026, DOI:10.32604/cmc.2025.070990 - 09 December 2025

Abstract Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet, this paper proposes a novel lightweight neural network model called ResghostNet. This model constructs the Resghost Module by combining residual connections and Adaptive-SE Blocks, which enhances the quality of generated feature maps through direct propagation of original input information and selection of important channels before cheap operations. Specifically, ResghostNet introduces residual connections on the basis of the Ghost Module to optimize the information flow, and designs a weight self-attention mechanism combined with SE blocks to enhance feature More >

Ruiping Wang, Chuang He, Shuo Zhang, Miaojun Xu^*, Zhuo Wang, Xiaoli Li^*, Bin Tao, Suliang Gao, Bin Li^*

Journal of Polymer Materials, Vol.42, No.4, pp. 1035-1049, 2025, DOI:10.32604/jpm.2025.073108 - 26 December 2025

Abstract The fabrication of highly flame-retardant polyamide 6 (PA6) composites is of great significance for expanding their practical applications. Herein, a new flame-retardant system (ADP/FA) was developed by combining aluminum diethylphosphinate (ADP) with excellent flame retardancy and fly ash (FA), an economical and environmentally friendly industrial waste. Due to the synergistic flame-retardant effect of ADP/FA in the condensed phase and gas phase, the PA6 composite containing only 11 wt% of ADP/FA (mass ratio 93:7) obtained vertical burning (UL-94) tests V-0 rating with a limiting oxygen index (LOI) of 30.9%. To obtain the same flame-retardant level of… More > Graphic Abstract

Min Zeng¹, Fan Yang¹, Jie Huang², Zhongkai Liao², Sheng Liu³, Xu Wang^1,*

Congenital Heart Disease, Vol.20, No.5, pp. 581-589, 2025, DOI:10.32604/chd.2025.070100 - 30 November 2025

Abstract Background: Psychosocial functioning and quality of life (QoL) are strongly associated with outcomes in pediatric heart transplant recipients. The data in pediatric transplantation, however, is limited. This study aims to investigate the associations of perioperative anxiety and depression with postoperative complications, sociodemographic and clinical characteristics. Methods: This observational, analytical, longitudinal study included 42 pediatric participants aged 8 to 16 years old. Preoperative psychological assessments were completed by 36 children, the remaining 6 were unable to participate due to invasive ventilation, extracorporeal membrane oxygenation (ECMO), and physical debilitation. Postoperatively, all 42 subjects completed the psychosocial evaluations. Data… More >

Yizhen Zhang^1,2,#, Juan Li^1,3,#, Huanqing Liu^1,4,#, Hong Xia¹, Jian Su^1,5, Fang Liu¹, Bo Su^6,*, Qi Su^1,*

Oncology Research, Vol.33, No.12, pp. 3869-3886, 2025, DOI:10.32604/or.2025.068689 - 27 November 2025

Abstract Objectives: Gastric cancer (GC) is often associated with high invasiveness, epithelial-mesenchymal transition (EMT), and resistance to 5-fluorouracil (5-FU), highlighting the need for novel therapeutic targets. This study explored whether diallyl disulfide (DADS) upregulates retinoic acid-related orphan receptor alpha (ROR) to weaken the protein kinase C alpha (PKC)/RORα-mediated RORα/β-catenin pathway, thereby inhibiting GC cell invasion, epithelial-mesenchymal transition (EMT), and enhancing 5-FU sensitivity. Methods: Human GC cell lines MGC-803 and SGC7901 were treated with DADS, RORα agonist SR1078/antagonist T0901317, and PKCα agonist TPA/antagonist GO6976. Cell proliferation (MTT), migration (scratch assay), invasion (Transwell), protein expression (Western blot), protein… More >

Seong-Su Yoon, Dong-Hyuk Shin, Ieck-Chae Euom^*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2683-2706, 2025, DOI:10.32604/cmes.2025.071577 - 26 November 2025

Abstract With the continuous expansion of digital infrastructures, malicious behaviors in host systems have become increasingly sophisticated, often spanning multiple processes and employing obfuscation techniques to evade detection. Audit logs, such as Sysmon, offer valuable insights; however, existing approaches typically flatten event sequences or rely on generic graph models, thereby discarding the natural parent-child process hierarchy that is critical for analyzing multiprocess attacks. This paper proposes a structure-aware threat detection framework that transforms audit logs into a unified two-dimensional (2D) spatio-temporal representation, where process hierarchy is modeled as the spatial axis and event chronology as the More >

Adel A.Abou El-Ela¹, Ragab A. El-Sehiemy^2,3,4,*, Abdallah Nazih¹, Asmaa A. Mubarak⁵, Eman S. Ali¹

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 1349-1388, 2025, DOI:10.32604/cmes.2025.069507 - 26 November 2025

Abstract Distribution systems face significant challenges in maintaining power quality issues and maximizing renewable energy hosting capacity due to the increased level of photovoltaic (PV) systems integration associated with varying loading and climate conditions. This paper provides a comprehensive overview on the exit strategies to enhance distribution system operation, with a focus on harmonic mitigation, voltage regulation, power factor correction, and optimization techniques. The impact of passive and active filters, custom power devices such as dynamic voltage restorers (DVRs) and static synchronous compensators (STATCOMs), and grid modernization technologies on power quality is examined. Additionally, this paper… More >

Yong Huang¹, Xiandeng Li¹, Qingling Jing¹, Qin Zhang¹, Chungui Huang^2,*

BIOCELL, Vol.49, No.11, pp. 2195-2216, 2025, DOI:10.32604/biocell.2025.072716 - 24 November 2025

Abstract Objective: Mesenchymal stem cells (MSCs) are important cells in bone tissue engineering. Bone morphogenetic protein-2 (BMP-2) effectively treats bone defects and nonunion. The purpose of this study is to investigate whether BMP-2 promotes bone formation and femoral fracture healing by inhibiting inflammation and promoting osteogenic differentiation of MSCs, in order to provide an experimental basis for developing more efficient fracture treatment strategies. Methods: Bone marrow-derived MSCs (BMSCs) were isolated from rats and treated with OE-BMP-2, the 5^′-adenosine monophosphate-activated protein kinase (AMPK) signal agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), and the inhibitor Compound C. Osteogenic differentiation was evaluated through… More >

Marta Reis^1,2,3,4,5,*, Catarina Noronha⁶, Gina Tomé^3,4,5, Marina Carvalho^4,6, Nuno Neto Rodrigues⁷, Margarida Gaspar de Matos^3,4,6

International Journal of Mental Health Promotion, Vol.27, No.10, pp. 1457-1470, 2025, DOI:10.32604/ijmhp.2025.070318 - 31 October 2025

Abstract Objectives: Academic Evaluation Anxiety is a significant psychological concern among adolescents, with well-documented impacts on academic performance, emotional well-being, and school engagement. In Portugal, recent evidence suggests growing pressure on students to achieve high academic standards, with psychosocial variables such as resilience, perceived support, and school environment playing a crucial role. This study aims to examine the prevalence and psychosocial predictors of Academic Evaluation Anxiety in Portuguese students, and to identify risk and protective factors that inform educational practice. Methods: This cross-sectional, quantitative study analysed data from 3083 students (5th to 12th grade) from the… More >