Yuan Guo^1,#, Hui Wang^2,#, Xiaoyu Zhao³, Xiao Feng³, Xingjian Cai⁴, Wei Li^3,*, Xiaohui Luo^4,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.078850 - 16 June 2026

Abstract Backgrounds: Early B-cell factor 1 (EBF1), originally identified as a critical transcription factor modulating the development and differentiation of B lymphocytes, has recently attracted significant interest owing to its diverse functional characteristics and regulatory mechanisms in solid tumors. Although current evidence suggests a potential connection between EBF1 and oncogenic developments, its exact role in the progression of prostate cancer (PCa) is unclear. This study sought to investigate its biological roles and regulatory mechanisms in human PCa. Methods: Bioinformatic analyses were performed utilizing Tumor Immune Estimation Resource (TIMER) 2.0, Gene Expression Profiling Interactive Analysis (GEPIA), and Gene… More >

Lei Wang¹, Hongji Luo², Yong Heng², Jingnan Tang², Xiaochuan Ju², Jianwei An^1,*, Haitao Xu¹, Xianwei Zhou¹

CMC-Computers, Materials & Continua, Vol.88, No.2, 2026, DOI:10.32604/cmc.2026.082418 - 15 June 2026

Abstract In intelligent connected vehicles (ICVs) system, driving users connect to service providers (SPs) to obtain location-based services (LBS). Users transmit large volumes of encrypted sensitive information related to their itineraries to SPs to access value-added services. Attackers may launch chosen-ciphertext attacks (CCA) against SPs by exploiting the malleability of homomorphic encryption. This enables adversaries to infer or steal private key information, thereby threatening the long-term privacy of user data. Furthermore, existing key management technologies in ICVs system predominantly rely on passive defense strategies and suffer from limitations such as single protection mechanisms, delayed updates, and More >

Junming Yan, Boran Xiong, Yingjie Zhu^*

BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.075319 - 09 June 2026

Abstract Objective: Neural stem cells (NSCs) are essential for replenishing nerve cells, providing neuroprotection, and repairing damaged brain function, while mitophagy is critical for maintaining NSCs’ homeostasis. The study investigated whether pyruvate kinase M2 (PKM2) regulates NSCs’ proliferation and differentiation by modulating mitophagy. Method: This study established a model of excessive autophagy in neural stem cell mitochondria induced by cobalt chloride (CoCl₂) and used plasmid transfection technology to knock down PKM2 expression, examining its effects on NSCs proliferation and differentiation. Additionally, potential mechanisms were explored by overexpressing phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and adding the… More > Graphic Abstract

Bizhen Lin^1,#, Wenzhong Lin^2,#, Dongmei Lian¹, Susu Yuan¹, Weiying Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.082698 - 27 May 2026

Abstract Grafting is a common strategy to control bacterial wilt (Ralstonia solanacearum) in susceptible crops, including pepper. However, the contribution of resistant rootstocks to scion immunity, beyond physical pathogen exclusion, requires further elucidation. In this study, susceptible ‘HF8’ scions were grafted onto six rootstock genotypes, and their resistance was evaluated via leaf-clip inoculation, which bypasses root-mediated physical barriers. Scions grafted onto resistant rootstocks exhibited restricted pathogen spread and higher survival rates; specifically, the NK4-HF8 combination demonstrated a 100% survival rate, compared to 11% in susceptible-rootstock combinations and 46% in self-grafted controls. Comparative transcriptomic profiling revealed distinct transcriptional… More >

José M. Campos-Salazar^1,*, Felipe Santander², Eduardo Keim³

Energy Engineering, Vol.123, No.6, 2026, DOI:10.32604/ee.2026.075407 - 27 May 2026

Abstract A nonlinear dynamic framework is developed to represent the coupled mass- and energy-transfer phenomena governing an industrial phosphate-pebble dryer. The formulation integrates combustion, gas–solid heat exchange, moisture evaporation, and exhaust-draft dynamics into a unified set of nonlinear differential equations suitable for transient analysis and control design. Steady-state operating conditions are first established, followed by local linearization to enable the synthesis of decentralized proportional–integral (PI) controllers using direct-synthesis principles. The resulting control architecture regulates key process variables, including vacuum pressure, outlet moisture content, and furnace temperature. The proposed model is implemented in MATLAB/Simulink using a modular… More > Graphic Abstract

Weixiang Song^1,#, Yanbo Zhang^2,#, Xubo Shen¹, Qin Yu¹, Yujin Liu¹, Yongchun Yu³, Rui Chen^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078665 - 21 May 2026

Abstract Objective: Osimertinib can selectively inhibit both epidermal growth factor receptor (EGFR) sensitizing and T790M gatekeeper mutations, and has shown remarkable therapeutic effects in patients with lung adenocarcinoma. However, almost all patients inevitably develop drug resistance. Herein, we sought to clarify the roles of exosomal lncRNA H19 in modulating osimertinib resistance, focusing on the PI3K-PTEN-Akt signaling axis. Methods: Functional assays, including cell viability assay, colony formation, cell apoptosis and xenograft mouse, employed in evaluate the effects of exosomal lncRNA H19 on cell growth and apoptosis. RNA quantitation and western blot were adopted to demonstrate the regulatory roles of… More >

Zhiye Zhou^1,2, Jianan Chen³, Qiang Zhu^3,*

BIOCELL, Vol.50, No.5, 2026, DOI:10.32604/biocell.2026.076758 - 13 May 2026

Abstract Background: Human dental pulp stem cells (hDPSCs) are promising for dental tissue regeneration. Dioscin (Dio), a natural compound, has various biological activities, but its effects on hDPSCs are unclear. This study aims to systematically elucidate the effects of Dio on promoting the osteogenic differentiation of hDPSCs and the underlying molecular mechanisms. Methods: Characterized hDPSCs were treated with Dio. Cell viability, proliferation, osteogenic differentiation (alkaline phosphatase (ALP) activity, Alizarin Red S (ARS)), and migration (Transwell) were assessed. Mitophagy (fluorescence, Western blot for PTEN-induced kinase 1 (PINK1), parkin RBR E3 ubiquitin-protein ligase (PRKN), microtubule-associated protein 1 light chain… More > Graphic Abstract

Soo-Hyun Sung¹, Seungwon Shin², Seok-Hwan Kim³, Minjung Park^4,*

International Journal of Mental Health Promotion, Vol.28, No.4, 2026, DOI:10.32604/ijmhp.2026.077710 - 28 April 2026

Abstract Objectives: Psychiatric inpatient care plays a critical role in stabilizing acute mental health crises, yet the optimal length of stay (LOS) and its impact on short-term clinical outcomes remain poorly defined across diagnostic groups. This study aimed to examine how LOS in psychiatric inpatient units is associated with clinical improvement at discharge and to determine whether this association differs across major diagnostic groups, using nationally representative hospital discharge data from Korea. Methods: A cross-sectional secondary analysis was conducted using the 2022–2023 Korea National Hospital Discharge In-depth Injury Survey. Adults whose primary discharge diagnosis was a mental… More >

Hanna Ahrnberg^1,*, Kaija Appelqvist-Schmidlechner², Pekka Mustonen¹, Sari Fröjd³, Katja Aktan-Collan¹

International Journal of Mental Health Promotion, Vol.28, No.4, 2026, DOI:10.32604/ijmhp.2026.077244 - 28 April 2026

Abstract Objectives: Positive Youth Development is an evidence-based, holistic approach that underlines adolescents’ strengths, competence, and interests instead of deficits, thus promoting psychosocial well-being in adolescents. This study aims to explore adolescents’ perceived impacts of the Finnish service-learning program “Gutsy Go”, which is based on a Positive Youth Development approach. Methods: The program educates 8th-grade comprehensive school students to perform good deeds in their communities and enhances adolescents’ psychosocial well-being. Focus group interviews were conducted two to three weeks after the program week with 61 program participants. The data was analyzed using qualitative content analysis. Results: Four broad More >

Ashuai Du^1,#, Dianbin Guo^2,#, Dongbo Yuan^3,#, Kai Li⁴, Yuanyuan Luo⁴, Songsong Tan³, Xuchao Dai⁴, Bo Yu⁵, Wanxiang You⁶, Junjie Zhao⁷, Bo Yan³, Kehua Jiang^3,*, Xiaofei Fan^2,*, Jianguo Zhu^3,*,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076716 - 22 April 2026

Abstract Background: Bisphenol A (BPA) is a widely used industrial chemical and endocrine-disrupting compound, and accumulating evidence suggests that it may contribute to prostate cancer progression; however, the underlying molecular mechanisms remain incompletely elucidated. This study aimed to elucidate the molecular targets and signaling pathways underlying BPA-induced prostate cancer progression. Methods: In this study, an integrated strategy combining network toxicology, molecular docking, and molecular dynamics simulations was employed to identify potential BPA-related targets and signaling pathways involved in prostate cancer. Candidate targets were retrieved from public databases, followed by protein-protein interaction network analysis to screen key… More >