Aktham Mestareehi^1,2,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.073745 - 22 April 2026

Abstract Objective: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, largely due to late diagnosis, molecular heterogeneity, and limited prognostic biomarkers. Aberrant protein phosphorylation plays a critical role in cancer progression by regulating DNA damage response, cell cycle control, and signaling pathways; however, the prognostic relevance of phosphorylation events in key DNA topology–related proteins remains incompletely understood. This study aimed to investigate the prognostic significance of phosphorylation of TOP1, TOP2A, TOP2B, and C1orf35 in HCC and to characterize their associated molecular features to identify potential diagnostic and therapeutic biomarkers. Methods: Publicly available HCC… More > Graphic Abstract

Qiguo Wang¹, Qin Wang², Wen Ye³, Qin Feng³, Ting Wang^3,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.075633 - 21 April 2026

Abstract Objectives: IgA nephropathy (IgAN) is a common primary glomerulonephritis with limited treatment options. Gallic acid (GA) has demonstrated renal protective effects, but its precise mechanisms against IgAN remain incompletely elucidated. This study aims to reveal the molecular mechanism by which GA exerts a renal protective effect on IgAN. Methods: Transcriptomics and network pharmacology were combined in an integrative manner. The GSE175759 dataset’s differentially expressed genes (DEGs) were filtered out. SwissTargetPrediction and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) were used to forecast GA’s goals. Core targets and pathways were obtained by functional… More >

Xingchang Fu, Gang Yang^*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.074951 - 21 April 2026

Abstract Objectives: Mitochondrial dysfunction and ferroptosis play crucial roles in osteoarthritis (OA), but the mechanisms remain unclear. This study aims to investigate the mechanism of sex-determining region Y-box transcription factor (SOX) 11/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) axis-mediated mitochondrial dysfunction and ferroptosis in OA. Methods: Destabilization of the medial meniscus (DMM) induced knee OA in mice. Chondrocytes were stimulated with IL-1β. Ferroptosis and mitochondrial function-related indicators were detected by immunofluorescence, 5,5^′,6,6^′-Tetrachloro-1,1^′,3,3^′-tetraethyl-imidacarbocyanine iodide (JC-1) staining, flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot. Results: OA mice had 4.4 and 1.1-fold increase in SOX11… More > Graphic Abstract

Jiangtao Yu^*, Qingfeng Huo, Xinxin Duan

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.073331 - 21 April 2026

Abstract Objectives: The tumor microenvironment and epithelial-mesenchymal transition (EMT) are closely linked to the progression of differentiated thyroid cancer (DTC). However, the functional mechanisms of lysine-specific demethylase 6B (KDM6B) in carcinogenesis remain incompletely understood. This study aims to clarify whether KDM6B affects DTC progression and EMT through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/AKT/mTOR) pathway, providing a potential target for clinical treatment of DTC. Methods: Tissue samples from DTC patients (n = 39) were collected, and KDM6B expression was determined through Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Western blot. Cell counting kit-8 assay, 5-Ethynyl-2^′-deoxyuridine… More > Graphic Abstract

George Liatsos^*, Kalliopi Zioutou, Konstantinos Avramidis, Konstantinos Vamvakaris, Maria Potamiti-Komi, Dimitrios Vassilopoulos

Canadian Journal of Urology, Vol.33, No.2, pp. 349-360, 2026, DOI:10.32604/cju.2026.072711 - 20 April 2026

Abstract Objectives: Bladder cancer (BC) is a prevalent malignancy with evolving treatment strategies and an increasingly aging patient population, resulting in a growing and complex burden of hospitalizations that extends beyond urological care and remains insufficiently characterized in real-world Internal Medicine settings. This study aimed to analyze the clinical data and outcomes for patients with BC admitted to the medicine ward. Additionally, this research presents three cases of fever of unknown origin, which all exhibited identical clinical and laboratory findings but ultimately resulted in different disease diagnoses. Methods: This retrospective case-series study included all adult patients… More >

Kamaljeet¹, Abhishek Vijukumar¹, Hardik Kumar^2,*, Shilpa Debnath², Sourabh Kosey¹

European Cytokine Network, Vol.37, No.1, pp. 13-24, 2026, DOI:10.32604/ecn.2026.078458 - 13 April 2026

Abstract Cytokine storm syndromes have become a much-invoked concept to describe severe immunopathology in infectious, inflammatory, and iatrogenic diseases, but the concept is poorly defined and often mechanistically imprecise. High levels of systemic cytokines have often been viewed as indicators of immune dysfunction, and based on this notion, therapeutic interventions focused on general cytokine inhibition are proposed. Nevertheless, a growing number of clinical and experimental data dispute the notion that hypercytokinemia is necessarily pathological. The present paper reconsiders cytokine storm syndromes in the light of an evolutionary, systems-immunology model, and suggests that most cytokine amplification conditions… More >

Yifan Wang¹, Xishun Qiu¹, Chao Wu¹, Jiazhao Li¹, Chang Dai¹, Bowen Han¹, Jinhu Hu², Mingliang Ma^1,*, Ye-Tang Pan^2,*

Journal of Polymer Materials, Vol.43, No.1, 2026, DOI:10.32604/jpm.2026.076443 - 03 April 2026

Abstract Polyurea (PUA) is widely valued in protective coatings and structural reinforcement because of its impressive mechanical strength and resistance to corrosion. Its high flammability, together with the poor dispersion that often comes with simply blending in flame retardants, continues to limit its use in demanding environments. To overcome these issues, this study introduces a different approach. We grafted 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) onto the surface of a metal–organic framework (MOF) and then partially amino-functionalized the DOPO layer, ultimately creating an amino-modified DOPO–MOF hybrid. The introduced amino groups can directly react with the isocyanate (–NCO) groups in the… More >

Chae-Young Lee¹, Yun-Jung Choi^2,*

International Journal of Mental Health Promotion, Vol.28, No.3, 2026, DOI:10.32604/ijmhp.2026.077116 - 31 March 2026

Abstract Background: Adolescent suicide remains a pressing public health concern in South Korea and worldwide, ranking as one of the leading causes of death among youth. Identifying modifiable risk and protective factors is critical for prevention strategies. Physical activity has been suggested as one such factor due to its potential mental health benefits. This study aimed to examine whether associations between physical activity and suicidality differ by activity type and by stage of suicidal behavior, distinguishing suicidal ideation, planning, and attempts among Korean adolescents. Methods: This cross-sectional secondary analysis used data from the 20th Korea Youth Risk… More >

Jingfei Shi^#, Yi Ding^#, Hui Lu^*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.073956 - 23 March 2026

Abstract Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Soluble interleukin-2 receptor alpha (sIL-2Rα) has been implicated in MS pathogenesis, but its mechanisms remain unclear. This study investigates how sIL-2Rα exacerbates MS by modulating microglial activation and antibody-dependent cellular cytotoxicity (ADCC) in an experimental autoimmune encephalomyelitis (EAE) mouse model. Methods: Female C57BL/6J mice were induced with EAE and treated with sIL-2Rα. Clinical symptoms, histopathology, and molecular changes were analyzed. Microglial activation was assessed via immunohistochemistry, Western blot, and RNA sequencing. In vitro, ADCC-mediated oligodendrocyte injury was evaluated using More >

Denisse A. Gutierrez^*, Elisa Robles-Escajeda, Jose A. Lopez-Saenz, Robert A. Kirken, Edgar A. Borrego, Ana P. Betancourt, Soumya Nair, Sourav Roy, Armando Varela-Ramirez, Renato J. Aguilera^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074945 - 23 March 2026

Abstract Objectives: Drug resistance is the major determinant of chemotherapy failure, leading to relapse and tumor progression, demonstrating the urgent need for novel antineoplastic drugs. This study aimed to evaluate the anticancer potential of two novel pyrazole derivatives, P3C.1 and P3C.2, and to elucidate their mechanism of action in cancer cells. Methods: The cytotoxicity of the compounds was evaluated across 27 different cancer cell lines via a nuclear staining assay. Subsequent flow cytometric and biochemical analyses were performed to assess reactive oxygen species (ROS) generation, apoptosis induction, mitochondrial integrity, and cell cycle progression. Additional studies included… More >