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  • Open Access

    ARTICLE

    A Study on Outlier Detection and Feature Engineering Strategies in Machine Learning for Heart Disease Prediction

    Varada Rajkumar Kukkala1, Surapaneni Phani Praveen2, Naga Satya Koti Mani Kumar Tirumanadham3, Parvathaneni Naga Srinivasu4,5,*

    Computer Systems Science and Engineering, Vol.48, No.5, pp. 1085-1112, 2024, DOI:10.32604/csse.2024.053603 - 13 September 2024

    Abstract This paper investigates the application of machine learning to develop a response model to cardiovascular problems and the use of AdaBoost which incorporates an application of Outlier Detection methodologies namely; Z-Score incorporated with Grey Wolf Optimization (GWO) as well as Interquartile Range (IQR) coupled with Ant Colony Optimization (ACO). Using a performance index, it is shown that when compared with the Z-Score and GWO with AdaBoost, the IQR and ACO, with AdaBoost are not very accurate (89.0% vs. 86.0%) and less discriminative (Area Under the Curve (AUC) score of 93.0% vs. 91.0%). The Z-Score and GWO… More >

  • Open Access

    ARTICLE

    Heart-Net: A Multi-Modal Deep Learning Approach for Diagnosing Cardiovascular Diseases

    Deema Mohammed Alsekait1, Ahmed Younes Shdefat2, Ayman Nabil3, Asif Nawaz4,*, Muhammad Rizwan Rashid Rana4, Zohair Ahmed5, Hanaa Fathi6, Diaa Salama AbdElminaam6,7,8

    CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3967-3990, 2024, DOI:10.32604/cmc.2024.054591 - 12 September 2024

    Abstract Heart disease remains a leading cause of morbidity and mortality worldwide, highlighting the need for improved diagnostic methods. Traditional diagnostics face limitations such as reliance on single-modality data and vulnerability to apparatus faults, which can reduce accuracy, especially with poor-quality images. Additionally, these methods often require significant time and expertise, making them less accessible in resource-limited settings. Emerging technologies like artificial intelligence and machine learning offer promising solutions by integrating multi-modality data and enhancing diagnostic precision, ultimately improving patient outcomes and reducing healthcare costs. This study introduces Heart-Net, a multi-modal deep learning framework designed to… More >

  • Open Access

    ARTICLE

    Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

    Wenjie Dong1,2,#, Zhibin Hong1,#, Aqian Wang2, Kaiyu Jiang2, Hai Zhu2, Fu zhang2, Zhaoxia Guo2, Hongling Su2,*, Yunshan Cao3,*

    Congenital Heart Disease, Vol.19, No.3, pp. 325-339, 2024, DOI:10.32604/chd.2024.052267 - 26 July 2024

    Abstract Background: Current guidelines for managing pulmonary arterial hypertension (PAH) recommend a risk stratification approach. However, the applicability and accuracy of these strategies for PAH associated with congenital heart disease (PAH-CHD) require further validation. This study aims to validate the reliability and predictive accuracy of a simplified stratification strategy for PAH-CHD patients over a three-year follow-up. Additionally, new prognostic variables are identified and novel risk stratification methods are developed for assessing and managing PAH-CHD patients. Methods: This retrospective study included 126 PAH-CHD patients. Clinical and biochemical variables across risk groups were assessed using Kruskal-Wallis and Fisher’s… More > Graphic Abstract

    Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

  • Open Access

    ARTICLE

    Transcatheter Closure of Postoperative Residual Atrial or Ventricular Septal Shunts in Patients with Congenital Heart Disease

    Jiawang Xiao, Jianming Wang, Zhongchao Wang, Lili Meng, Ming Zhao, Qiguang Wang*

    Congenital Heart Disease, Vol.19, No.3, pp. 293-303, 2024, DOI:10.32604/chd.2024.051427 - 26 July 2024

    Abstract Background: Transcatheter closure (TCC) has emerged as the preferred treatment for selected congenital heart disease (CHD). While TCC offers benefits for patients with postoperative residual shunts, understanding its mid- and long-term efficacy and safety remains crucial. Objective: This study aims to assess the mid- and long-term safety and efficacy of TCC for patients with residual atrial or ventricular septal shunts following CHD correction. Methods: In this consecutive retrospective study, we enrolled 35 patients with residual shunt who underwent TCC or surgical repair of CHD between June 2011 to October 2022. TCC candidacy was determined based on… More >

  • Open Access

    ARTICLE

    Ensemble Approach Combining Deep Residual Networks and BiGRU with Attention Mechanism for Classification of Heart Arrhythmias

    Batyrkhan Omarov1,2,*, Meirzhan Baikuvekov1, Daniyar Sultan1, Nurzhan Mukazhanov3, Madina Suleimenova2, Maigul Zhekambayeva3

    CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 341-359, 2024, DOI:10.32604/cmc.2024.052437 - 18 July 2024

    Abstract This research introduces an innovative ensemble approach, combining Deep Residual Networks (ResNets) and Bidirectional Gated Recurrent Units (BiGRU), augmented with an Attention Mechanism, for the classification of heart arrhythmias. The escalating prevalence of cardiovascular diseases necessitates advanced diagnostic tools to enhance accuracy and efficiency. The model leverages the deep hierarchical feature extraction capabilities of ResNets, which are adept at identifying intricate patterns within electrocardiogram (ECG) data, while BiGRU layers capture the temporal dynamics essential for understanding the sequential nature of ECG signals. The integration of an Attention Mechanism refines the model’s focus on critical segments… More >

  • Open Access

    ARTICLE

    Cardiovascular Disease Prediction Using Risk Factors: A Comparative Performance Analysis of Machine Learning Models

    Adil Hussain1,*, Ayesha Aslam2

    Journal on Artificial Intelligence, Vol.6, pp. 129-152, 2024, DOI:10.32604/jai.2024.050277 - 21 May 2024

    Abstract The diagnosis and prognosis of cardiovascular diseases are critical medical responsibilities that assist cardiologists in correctly classifying patients and treating them accordingly. The utilization of machine learning in the medical domain has witnessed a notable surge due to its ability to discern patterns from vast amounts of data. Machine learning algorithms that can categorize cases of cardiovascular illness may help doctors reduce the number of wrong diagnoses. This research investigates the efficacy of different machine learning algorithms in predicting cardiovascular disease in accordance with risk factors. This study utilizes a variety of machine learning models, More >

  • Open Access

    ARTICLE

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

    Shuliang Xia1,2,3,#, Huikang Tao2,#, Shixin Su4, Xinxin Chen2, Li Ma2, Jianru Li5, Bei Gao6, Xumei Liu5, Lei Pi7, Jinqing Feng4, Fengxiang Li2, Jia Li4,*, Zhiwei Zhang1,3,*

    Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583 - 16 May 2024

    Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More > Graphic Abstract

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

  • Open Access

    EDITORIAL

    Health Systems Strengthening to Tackle the Global Burden of Pediatric and Congenital Heart Disease: A Diagonal Approach

    Dominique Vervoort1,2,3,*, Amy Verstappen3, Sreehari Madhavankutty Nair4, Chong Chin Eu5, Bistra Zheleva3,6

    Congenital Heart Disease, Vol.19, No.2, pp. 131-138, 2024, DOI:10.32604/chd.2024.049814 - 16 May 2024

    Abstract This article has no abstract. More >

  • Open Access

    CASE REPORT

    Stubborn Hypoxia in Neonates with D-Transposition of the Great Arteries after Arterial Switch Operation: Central Sleep Apnea as the Cause and Potential Indicator of Brain Immaturity

    Camden L. Hebson1,*, Kyle Bliton2, Amr Y. Hammouda1, Kaitlyn Barr3, W. Hampton Gray4, Mohini Gunnett2, Waldemar F. Carlo1

    Congenital Heart Disease, Vol.19, No.2, pp. 185-195, 2024, DOI:10.32604/chd.2024.048871 - 16 May 2024

    Abstract D-transposition of the great arteries (d-TGA) is surgically repaired with the arterial switch operation (ASO) with excellent results, however short and long-term morbidities still develop including neurocognitive delay. Clinically significant central sleep apnea is uncommon in non-premature infants, but when present indicates immature autonomic control of respiration likely due to a neurologic disorder. We report the unanticipated finding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO, with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal development. Within More >

  • Open Access

    REVIEW

    Machine Learning-Based Intelligent Auscultation Techniques in Congenital Heart Disease: Application and Development

    Yang Wang#, Xun Yang#, Mingtang Ye, Yuhang Zhao, Runsen Chen, Min Da, Zhiqi Wang, Xuming Mo, Jirong Qi*

    Congenital Heart Disease, Vol.19, No.2, pp. 219-231, 2024, DOI:10.32604/chd.2024.048314 - 16 May 2024

    Abstract Congenital heart disease (CHD), the most prevalent congenital ailment, has seen advancements in the “dual indicator” screening program. This facilitates the early-stage diagnosis and treatment of children with CHD, subsequently enhancing their survival rates. While cardiac auscultation offers an objective reflection of cardiac abnormalities and function, its evaluation is significantly influenced by personal experience and external factors, rendering it susceptible to misdiagnosis and omission. In recent years, continuous progress in artificial intelligence (AI) has enabled the digital acquisition, storage, and analysis of heart sound signals, paving the way for intelligent CHD auscultation-assisted diagnostic technology. Although More > Graphic Abstract

    Machine Learning-Based Intelligent Auscultation Techniques in Congenital Heart Disease: Application and Development

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