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  • Open Access

    ARTICLE

    An Enhanced Multiview Transformer for Population Density Estimation Using Cellular Mobility Data in Smart City

    Yu Zhou1, Bosong Lin1, Siqi Hu2, Dandan Yu3,*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 161-182, 2024, DOI:10.32604/cmc.2024.047836

    Abstract This paper addresses the problem of predicting population density leveraging cellular station data. As wireless communication devices are commonly used, cellular station data has become integral for estimating population figures and studying their movement, thereby implying significant contributions to urban planning. However, existing research grapples with issues pertinent to preprocessing base station data and the modeling of population prediction. To address this, we propose methodologies for preprocessing cellular station data to eliminate any irregular or redundant data. The preprocessing reveals a distinct cyclical characteristic and high-frequency variation in population shift. Further, we devise a multi-view enhancement model grounded on the… More >

  • Open Access

    ARTICLE

    MSC-YOLO: Improved YOLOv7 Based on Multi-Scale Spatial Context for Small Object Detection in UAV-View

    Xiangyan Tang1,2, Chengchun Ruan1,2,*, Xiulai Li2,3, Binbin Li1,2, Cebin Fu1,2

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 983-1003, 2024, DOI:10.32604/cmc.2024.047541

    Abstract Accurately identifying small objects in high-resolution aerial images presents a complex and crucial task in the field of small object detection on unmanned aerial vehicles (UAVs). This task is challenging due to variations in UAV flight altitude, differences in object scales, as well as factors like flight speed and motion blur. To enhance the detection efficacy of small targets in drone aerial imagery, we propose an enhanced You Only Look Once version 7 (YOLOv7) algorithm based on multi-scale spatial context. We build the MSC-YOLO model, which incorporates an additional prediction head, denoted as P2, to improve adaptability for small objects.… More >

  • Open Access

    ARTICLE

    Contrastive Consistency and Attentive Complementarity for Deep Multi-View Subspace Clustering

    Jiao Wang, Bin Wu*, Hongying Zhang

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 143-160, 2024, DOI:10.32604/cmc.2023.046011

    Abstract Deep multi-view subspace clustering (DMVSC) based on self-expression has attracted increasing attention due to its outstanding performance and nonlinear application. However, most existing methods neglect that view-private meaningless information or noise may interfere with the learning of self-expression, which may lead to the degeneration of clustering performance. In this paper, we propose a novel framework of Contrastive Consistency and Attentive Complementarity (CCAC) for DMVsSC. CCAC aligns all the self-expressions of multiple views and fuses them based on their discrimination, so that it can effectively explore consistent and complementary information for achieving precise clustering. Specifically, the view-specific self-expression is learned by… More >

  • Open Access

    ABSTRACT

  • Open Access

    ARTICLE

    Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

    MARKO SKELIN1,2,3,*, BRUNA PERKOV-STIPIČIN1, SANJA VUŠKOVIĆ4, MARINA ŠANDRK PLEHAČEK5, ANE BAŠIĆ6, DAVID ŠARČEVIĆ7, MAJA ILIĆ8, IVAN KREČAK2,3,9

    Oncology Research, Vol.32, No.5, pp. 807-815, 2024, DOI:10.32604/or.2024.048948

    Abstract Background: The European Society for Medical Oncology (ESMO) guidelines are among the most comprehensive and widely used clinical practice guidelines (CPGs) globally. However, the level of scientific evidence supporting ESMO CPG recommendations has not been systematically investigated. This study assessed ESMO CPG levels of evidence (LOE) and grades of recommendations (GOR), as well as their trends over time across various cancer settings. Methods: We manually extracted every recommendation with the Infectious Diseases Society of America (IDSA) classification from each CPG. We examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer types.… More >

  • Open Access

    REVIEW

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

    KARAN WADHWA1, PAYAL CHAUHAN1, SHOBHIT KUMAR2, RAKESH PAHWA3,*, RAVINDER VERMA4, RAJAT GOYAL5, GOVIND SINGH1, ARCHANA SHARMA6, NEHA RAO3, DEEPAK KAUSHIK1,*

    Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

    Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More > Graphic Abstract

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

  • Open Access

    REVIEW

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

    NILAM BHUSARE, MAUSHMI KUMAR*

    Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

    Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More > Graphic Abstract

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

  • Open Access

    ARTICLE

    A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients

    YAN ZHANG, HEYANG ZHANG, JING WANG, XIN WEI, YI QU, FENG XU, LIJUN ZHANG*

    Oncology Research, Vol.32, No.5, pp. 955-963, 2024, DOI:10.32604/or.2023.043922

    Abstract Background: Bortezomib results in peripheral neuropathy (PN) in approximately 50% of patients, during multiple myeloma (MM) treatment, a complication known as Bortezomib-induced peripheral neuropathy (BIPN). The drug response varies among individuals. Genetic factor may play an important role in BIPN. Methods: A next-generation sequencing (NGS) panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy. mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR (RT-qPCR). Serum homocysteine (Hcy) levels were detected in 40 samples by chemiluminescent microparticle immunoassay… More > Graphic Abstract

    A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients

  • Open Access

    REVIEW

    Deciphering resistance mechanisms and novel strategies to overcome drug resistance in ovarian cancer: a comprehensive review

    EFFAT ALEMZADEH1, LEILA ALLAHQOLI2, AFROOZ MAZIDIMORADI3, ESMAT ALEMZADEH1,4, FAHIMEH GHASEMI4,5, HAMID SALEHINIYA6, IBRAHIM ALKATOUT7,*

    Oncology Research, Vol.32, No.5, pp. 831-847, 2024, DOI:10.32604/or.2024.031006

    Abstract Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for maintenance therapy. However, resistance to these new drugs has emerged. Therefore, understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective… More >

  • Open Access

    ARTICLE

    Detection of Student Engagement in E-Learning Environments Using EfficientnetV2-L Together with RNN-Based Models

    Farhad Mortezapour Shiri1,*, Ehsan Ahmadi2, Mohammadreza Rezaee1, Thinagaran Perumal1

    Journal on Artificial Intelligence, Vol.6, pp. 85-103, 2024, DOI:10.32604/jai.2024.048911

    Abstract Automatic detection of student engagement levels from videos, which is a spatio-temporal classification problem is crucial for enhancing the quality of online education. This paper addresses this challenge by proposing four novel hybrid end-to-end deep learning models designed for the automatic detection of student engagement levels in e-learning videos. The evaluation of these models utilizes the DAiSEE dataset, a public repository capturing student affective states in e-learning scenarios. The initial model integrates EfficientNetV2-L with Gated Recurrent Unit (GRU) and attains an accuracy of 61.45%. Subsequently, the second model combines EfficientNetV2-L with bidirectional GRU (Bi-GRU), yielding an accuracy of 61.56%. The… More >

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